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The molecular basis of human igg-mediated enhancement of C4b-binding protein recruitment to group a streptococcus
Streptococcus pyogenes infects over 700 million people worldwide annually. Immune evasion strategies employed by the bacteria include binding of the complement inhibitors, C4b-binding protein (C4BP) and Factor H in a human-specific manner. We recently showed that human IgG increased C4BP binding to the bacterial surface, which promoted streptococcal immune evasion and increased mortality in mice.
Engineering of pyranose 2-oxidase: Improvement for biofuel cell and food applications through semi-rational protein design
Pyranose 2-oxidase (P20x) has several proposed biotechnological applications such as a bio-component in biofuel cells or for carbohydrate transformations. To improve some of the catalytic properties of P20x from Trametes multicolor, we selected a semi-rational approach of enzyme engineering, saturation mutagenesis of active-site residues and subsequent screening of mutant libraries for improved ac
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Nyhetsbrev Från GÅS-projektet Mars 2025
Nyhetsbrev från GÅS-projektet mars 2025 Professor Sölve Elmståhl har ordet Temat för detta nyhetsbrev är nya forskningsfynd i GÅS-studien. Show as web page I detta nyhetsbrev berättar vi om aktuella forskningsfrågor och resultat som utgår ifrån insamlade data från GÅS- projektet. Fler projekt rör riskfaktorer för vanliga kroniska sjukdomar som nedsatt njur- och lungfunktion, högt blodtryck och på