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Asthma patients who continue to experience symptoms despite taking regular inhaled corticosteroids represent a management challenge. Leukotrienes play a key role in asthma pathophysiology, and since pro-inflammatory leukotrienes are poorly suppressed by corticosteroids it seems rational to add a leukotriene receptor antagonist (LTRA) when a low to moderate dose of inhaled corticosteroids does not
The importance of the N-terminal region of human cystatin C or chicken cystatin for the kinetics of interactions of the inhibitors with four cysteine proteinases was characterized. The association rate constants for the binding of recombinant human cystatin C to papain, ficin, actinidin and recombinant rat cathepsin B were 1.1 x 10(7), 7.0 x 10(6), 2.4 x 10(6) and 1.4 x 10(6) M-1.s-1, whereas the
The aim was to investigate quality of life (QoL) in elderly persons newly diagnosed with cancer (65+ years) in relation to age, contact with the health-care system, ability to perform activities of daily living (ADL), hope, social network and support, and to identify which factors were associated with low QoL. The sample consisted of 101 patients (75 women and 26 men) newly diagnosed with cancer.
Background: Brief Admission is a crisis and risk management strategy in which self-harming and suicidal individuals with three or more diagnostic criteria of borderline personality disorder self-admit to hospital at times of increasing risk when other efforts to stay safe are failing. Standardized in the current randomized controlled trial, the intensity of Brief Admission Skåne is implemented in
Allogeneic hematopoietic stem cell transplantation (HSCT) is beneficial for pediatric patients with relapsed or (very) high-risk acute lymphoblastic leukemia (ALL) in remission. A total of 1115 consecutive patients were included in the ALL SCT 2003 BFM study and the ALL SCT 2007 I-BFM study and were stratified according to relapse risk (standard versus high versus very high risk of relapse) and do
A search is presented for the pair production of heavy vector-like B quarks, primarily targeting B quark decays into a W boson and a top quark. The search is based on 36.1 fb−1 of pp collisions at s=13 TeV recorded in 2015 and 2016 with the ATLAS detector at the CERN Large Hadron Collider. Data are analysed in the lepton-plus-jets final state, characterised by a high-transverse-momentum isolated e
A search is presented for the pair production of heavy vector-like T quarks, primarily targeting the T quark decays to a W boson and a b-quark. The search is based on 36.1 fb−1 of pp collisions at s=13 TeV recorded in 2015 and 2016 with the ATLAS detector at the CERN Large Hadron Collider. Data are analysed in the lepton-plus-jets final state, including at least one b-tagged jet and a large-radius
A search for a heavy neutral Higgs boson, A, decaying into a Z boson and another heavy Higgs boson, H, is performed using a data sample corresponding to an integrated luminosity of 36.1 fb−1 from proton–proton collisions at s=13 TeV recorded in 2015 and 2016 by the ATLAS detector at the Large Hadron Collider. The search considers the Z boson decaying to electrons or muons and the H boson into a pa
Background: Type 1 von Willebrand disease (VWD) is a congenital bleeding disorder characterized by a partial quantitative deficiency of plasma von Willebrand factor (VWF) in the absence of structural and/or functional VWF defects. Accurate assessment of the quantity and quality of plasma VWF is difficult but is a prerequisite for correct classification. Objective: To evaluate the proportion of mis
Femoroacetabular impingement (FAI) represents a heterogeneous group of disorders that affect a diverse patient population. The natural history of the disease, the role of nonsurgical management, the indications for surgery, optimal surgical techniques, and the predictors of treatment outcomes need to be further defined. To date, clinical research reports have included primarily surgical case serieFemoroacetabular impingement (FAI) represents a heterogeneous group of disorders that affect a diverse patient population. The natural history of the disease, the role of nonsurgical management, the indications for surgery, optimal surgical techniques, and the predictors of treatment outcomes need to be further defined. To date, clinical research reports have included primarily surgical case serie
Digital technologies have become a part of everyday life, and are now taken for granted, especially by younger generations – the Digital Natives. This new generation of users has grown up surrounded by information technology and therefore embedded the digital into their habitus. They have mastered to combine digital and non-digital artifacts in order to adopt their everyday networks to their indiv
Inadequate water infrastructural development and high costs of water are few of the many challenges that affect water access in Kibera. Consequently, many alternatives to piped water grew out of necessity to meet the needs of residents. The aim of this thesis is to examine the conditions that have led to poor water provision in Kibera and how transitions to improved water access can be achieved by
The aim of this study was to analyze different prominent discourses within Swedish compulsory care judgments (LVM) in relation to pregnant substance abusers and the unborn child, as well as examine how these different discourses relate to each other. The aim was furthermore to reveal existing expectations within the administrative law context in relation to the pregnant women and the unborn child.
Technical assistance to public sector organisations is a much-debated topic and showcases a considerable size in contemporary international development assistance. Yet, the empirical evidence base on which factors contribute to the outcomes of projects within this field is surprisingly slim and diffuse. Particularly, the mechanisms through which different factors affect project outcomes remains un
Peatlands store a substantial amount of carbon in the terrestrial ecosystem. They are both long-term sinks of organic carbon and a major natural source of atmospheric methane. The accumulation of carbon is a result of net primary production surpassing decomposition rates over millennia, whereas methane production is intricately linked to the anaerobic decomposition of carbon mass. Warming-induced
User guide - National 7T facility Version 6, updated 2019-10-16 Responsible authors: Karin Markenroth Bloch (LBIC), Freddy Ståhlberg, Isabella Björkman-Burtscher 1 User guide National 7T facility Lund University BioImaging Center (LBIC), Lund University and Department of Medical Imaging and Physiology (BoF), Skåne University Hospital (SUS); Region Skåne User guide - National 7T facility Version 6,
https://www.lbic.lu.se/sites/lbic.lu.se/files/7t_user_guide_20191016.pdf - 2026-07-12
User guide - National 7T facility Version 6, updated 2019-10-23 Responsible authors: Karin Markenroth Bloch (LBIC), Freddy Ståhlberg, Isabella Björkman-Burtscher 1 User guide National 7T facility Lund University BioImaging Center (LBIC), Lund University and Department of Medical Imaging and Physiology (BoF), Skåne University Hospital (SUS); Region Skåne User guide - National 7T facility Version 6,
https://www.lbic.lu.se/sites/lbic.lu.se/files/7t_user_guide_20191023.pdf - 2026-07-12
This study examines how Canadian news media discourse constructed and contested medical assistance in dying (MAiD) eligibility for people with mental illness as the sole underlying medical condition between 2020 and 2025. Drawing on boundary theory, framing theory, Wimmer’s (2008) taxonomy of boundary-making strategies, and Brante and Hallberg’s (1991) concept of incommensurability, this study app
Ukraine has the second highest rates of the human immunodeficiency virus (HIV) in Europe and struggles with the HIV epidemic since the 1990s. Adolescent girls and young women (AGYW) are especially vulnerable due to their social position and biological characteristics. The HIV incidence is still on the rise, which is also fostered by the ongoing conflict in the East, although a great number of nati
