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Popular Abstract in Swedish Vävnadskallikrein (VK) är ett äggvitespjälkande protein som dels kan aktivera vävnadsnedbrytande enzymer som kollagenas och gelatinas och dels spjälkar kininogen till kininer (bradykinin och kallidin). Via bindning till speciella kininreceptorer (B2 receptorer) som finns överallt i kroppen, styr kininerna olika processer i de flesta av kroppens organ och vävnader såsom Tissue kallikrein releases pharmacollogically highly active kinins from kininogen. Many other enzymes may also release kinins. The aim of the study was to clarify the pathophysiological role of tissue kallikrein in acute pancreatitis. Two sensitive and specific radioimmunoassays for porcine and human tissue kallikrein were developed. A large release of tissue kallikrein from the pancreatic gland

Objective: To determine the validity of 15 standardized instruments frequently used to measure the outcome of chronic arthritis treatment. Methods: Analyses were performed on data collected at a rehabilitation programme (n=216). The outcome measures evaluated were health-related quality of life, global health, pain, physical function and aerobic capacity. The instrument items were linked to the In

A search is presented for production of a heavy up-type quark (t') together with its antiparticle, assuming a significant branching ratio for subsequent decay into a W boson and a b quark. The search is based on 4.7 fb(-1) of pp collisions root s = 7 TeV recorded in 2011 with the ATLAS detector at the CERN Large Hadron Collider. Data are analyzed in the lepton + jets final state, characterized by

Background--Long-term disease progression after myocardial infarction (MI) is inadequately understood. We evaluated the pattern and angiographic properties (culprit lesion [CL]/non-CL [NCL]) of recurrent MI (re-MI) in a large real-world patient population. Methods and Results--Our observational study used prospectively collected data in 108 615 patients with first-occurrence MI enrolled in the SWE

Background: Depression is linked with alexithymia, anxiety, high HbA1c concentrations, disturbances of cortisol secretion, increased prevalence of diabetes complications and all-cause mortality. The psycho-educational method 'affect school with script analysis' and the mind-body therapy 'basic body awareness treatment' will be trialled in patients with diabetes, high HbA1c concentrations and psych

Objective: Men who have sex with men (MSM) in sub-Saharan Africa remain hidden and hard to reach for involvement in HIV and sexually transmitted infection (STI) services. The aim of the current study was to describe MSM social networks in a large and a small Tanzanian city in order to explore their utility for peer-based healthcare interventions. Methods: Data were collected through respondent-dri

Treatment with chemotherapy, radiotherapy, or surgery that involves reproductive organs can cause impaired spermatogenesis, testosterone deficiency, and physical sexual dysfunction in male pubertal, adolescent, and young adult cancer survivors. Guidelines for surveillance and management of potential adverse effects could improve cancer survivors' health and quality of life. Surveillance recommenda

A search for a heavy neutral Higgs boson, A, decaying into a Z boson and another heavy Higgs boson, H, is performed using a data sample corresponding to an integrated luminosity of 139 fb- 1 from proton–proton collisions at s=13 TeV recorded by the ATLAS detector at the LHC. The search considers the Z boson decaying into electrons or muons and the H boson into a pair of b-quarks or W bosons. The m

Aims: Drug development for paediatric pulmonary arterial hypertension (PAH) ispressingly needed. Experts from the US Food and Drug Administration, EuropeanMedicines Agency, Health Canada, key opinion leaders, academia, patients, and industry representatives held a workshop on 12th June 2017 dedicated to addressing challenges and unmet needs. This report summarises the approaches proposed during th

We compared facial growth in patients with bilateral complete cleft lip and palate (BCLP) in whom the palate had been repaired by the von Langenbeck procedure at the age of 14 months (L-14), or by the Wardill procedure at 18 months (W-18). A total of 151 unaffected subjects were used as a reference group. Thirty-six adult patients, 26 in the L-14 group, and 10 in the W-18 group, were investigated

The purpose of this study was to compare facial growth in patients with unilateral complete cleft lip and palate (UCLP) in whom the palate was repaired with the von Langenbeck procedure at 8 months (L-8), or the Wardill procedure at 18 months (W-18). A total of 151 unaffected subjects were used as a reference series. Sixty-one adult patients, 34 in the L-8 group and 27 in the W-18 group, were inve

Denna uppsats syftar till att fastställa hur införandet av Enhetliga Patent och den Europeiska- och EU-patentdomstolen kommer att påverka läkemedelsindustrins val av patentansökningsförfarande när de ansöker om patent i Europa i framtiden. För att fastställa de förväntade effekterna av Enhetliga Patent på branschen har intervjuer med ett urval personer inom forskning- och utvecklingsföretag och enThis thesis aims to establish how the introduction of the Unitary Patent and the European and European Union Patent Court will affect the pharmaceutical industry’s choice of patent application route when applying for patents in Europe in the future. To establish the expected effect of the Unitary Patent on the industry interviews with a selection of professionals in the research and development in

The aim of this study was to analyze different prominent discourses within Swedish compulsory care judgments (LVM) in relation to pregnant substance abusers and the unborn child, as well as examine how these different discourses relate to each other. The aim was furthermore to reveal existing expectations within the administrative law context in relation to the pregnant women and the unborn child.

Background AB Ångpanneföreningen (ÅF) is one of the largest and oldest technical consulting firms in Sweden. The company was founded in 1895 and has witnessed four big technical advances: steam power, electricity, nuclear power and computerization. The company provides qualified services and solutions for industrial processes, infrastructural projects and in the development of products as well as

En wollastonitförekomst vid Stor Hulta gruvor i närheten av Nora har undersökts. I den nedlagda gruvan har tidigare skarnjärnmalm tillhörande leptitformationen brutits. I jämförande syfte har även wollastonit från Akatjvare i Tjåmotisområdet undersökts. Detta är LKAB:s prospekteringsobjekt och är beläget i Jokkmokks kommun. Resultaten för detta material, som utgörs av fyra stuffer av dubbel knytnäThe wollastonite occurrence at Hulta is a skarn deposit associated with iron ore within the Leptite Formation of central Sweden. Wollastonite is found in carbonate layers within the leptite and the rocks have been subject to regional metamorphism. These layers are normally approximately 10 cm thick. Corelogging, microscopic studies and X-ray diffraction show a varied composition of the rock, with

This thesis investigates Swedish voters’ perceptions of political branding and its consequences in a nation characterized by high institutional trust and low corruption. Political branding, a tool for shaping voter opinions, perceptions, and behavior, has gained significant traction in recent years. While traditionally viewed as beneficial for democracy, emerging critiques suggest it may hinder co

Chile’s exposure to multiple natural hazards and its fragmented resilience governance highlight the urgent need for a standardised measurement tool. This thesis adapts an Australian framework to develop the Resiliencia Sistémica, Integral, Social y Territorial para Emergencias (RESISTE), a top-down, indicator-based framework rooted in socio-ecological system thinking and tailored to Chile’s contex

The building and construction industry is responsible for around 40% of global greenhouse gas emissions, driving the urgent need for new regulations. As such, the life cycle assessment (LCA) methodology has become fundamental for evaluating environmental impacts. Despite the need for digital tools to support environmental performance evaluations, the lack of guidance on developing such tools hinde