Filtyp
Background: Podocalyxin-like 1 (PODXL) is a cell-adhesion glycoprotein and stem cell marker that has been associated with an aggressive tumour phenotype and adverse outcome in several cancer types. We recently demonstrated that overexpression of PODXL is an independent factor of poor prognosis in colorectal cancer (CRC). The aim of this study was to validate these results in two additional indepen
BACKGROUND: Hemostatic disorders are common in obstetric complications. Thromboelastography (TEG (R)) simultaneously measures coagulation and fibrinolysis within 10 to 20 minutes. Our primary aim in this prospective longitudinal study was to obtain knowledge about physiological changes in TEG (R) variables during normal pregnancy and 8 weeks postpartum. The secondary aims were to compare TEG (R) v
The complement system, a part of the innate immune system with several links to the adaptive immune system, plays an important role in the pathogenesis of many diseases. The purpose of this thesis was to document and clarify some of these mechanisms. The thesis is based on four papers (I-IV). (I and II) Autoantibodies to the C3 cleaving enzyme complex of the alternative pathway, C3 nephritic facto
Objective: Transcatheter valve-in-valve implantation has emerged as an option, in addition to reoperative surgical aortic valve replacement, to treat failed biologic heart valve substitutes. However, the clinical experience with this approach is still limited. We report the comprehensive experience of transcatheter valve-in-valve implantation in the Nordic countries from May 2008 to January 2012.
BACKGROUND: Certain immune-mediated diseases (IMDs), such as rheumatoid arthritis and systemic lupus erythematosus, have been linked to cardiovascular disorders. We examined whether there is an association between 32 different IMDs and risk of subsequent hospitalization for coronary heart disease (CHD) related to coronary atherosclerosis in a nationwide follow up study in Sweden. METHODS AND FIND
Background: Although omic-based discovery approaches can provide powerful tools for biomarker identification, several reservations have been raised regarding the clinical applicability of gene expression studies, such as their prohibitive cost. However, the limited availability of antibodies is a key barrier to the development of a lower cost alternative, namely a discrete collection of immunohist
The desire for a deeper connection with nature has become increasingly apparent. The shift towards eco-conscious living, as demonstrated by the popularity of gorpcore and the nomad lifestyle, shows that people want to make more sustainable and nature-inspired choices. In response to this cultural shift, I am motivated to channel these environmental sentiments into a design project — the creation
Framställningen belyser och analyserar värdeöverföringsproblematiken vid överlåtelse av egendom från fåmansbolag till närståendebolag. Aktieägarna, som indirekt både är överlåtare och förvärvare av egendomen, kan vilja att överlåtelsen ska ske till ett så lågt pris som möjligt. Men de måste hålla sig inom ramarna för värdeöverföringsreglerna i 17 kap. ABL om de inte vill riskera långtgående sanktiThe thesis highlights and analyses the value transfer problem arising when transferring property from a close company to a related company. The shareholders, who indirectly are both transferors and transferees of the property, may wish to undertake such transfer at the lowest price possible. Nonetheless they have to stay within the limits of the value transfer rules in section 17 in the Swedish Co
Det har blivit vardag för allmänheten att dagligen läsa rubriker om sprängningar, skjutningar, mord och narkotikabrott. Dessa brott har ökat de senaste åren, så pass mycket att många inte längre höjer på ögonbrynen när man läser om det i medierna. Osäkerheten och otryggheten i samhället har ökat i takt med att den organiserade brottsligheten har ökat. De senaste åren har den organiserade brottsliIt has become commonplace for the general public in Sweden to read daily news reports about explosions, shootings, homicides, and narcotics related crimes. These types of crimes have increased during the last years, to such an extent that many people do not feel safe. With rising crime rates, there is an increased sense of insecurity and uncertainty. The criminals have adopted new technologies, a
Background The two main functional goals of postural control are postural stability (balance) and postural orientation. Postural orientation is the ability to maintain alignment between body segments and the environment during a static or dynamic activity. Nae et al. have evaluated the measurement properties of a clinical test battery for assessing postural orientation errors (POEs) in patients wi
Purpose: The purpose of this study is to develop a framework for distribution center location in order to reduce distribution costs for small, fast growing companies on the Nordic market. Methodology: In the methodology chapter, relevant research methodology for the type of study conducted in this report is presented. It is concluded that a case study is the most suitable approach for the purpose
Aircraft observations of precipitating clouds with cloud top temperatures higher than -38°C have revealed that Secondary Ice Production (SIP) is responsible for presence of majority of ice particles. One such SIP mechanism is fragmentation via collisions between ice particles. The central theme of this study is to understand the dependencies of this SIP mechanism and improve its existing numerical
Forests form the backbone of the European terrestrial carbon sink (State Forest Service & Ministry of Environment, 2018). As the European Union (EU) strives to become climate neutral by 2050, forests are accounted for the natural carbon absorption mechanism (European Commission, n.d.). Currently, the European net land carbon sink is decreasing largely due to forest ageing (Pilli et al., 2022),
This master thesis project was performed in collaboration with Johnson Matthey. Johnson Matthey is a worldwide company working with sustainable technologies. The site in Perstorp, where this work was performed, focus on formaldehyde production. In order to continuously improve chemical processes, simulation and modeling are advantageous tools. They can give a better understanding of the processes
Recent global warming trends, particularly in the arctic regions and Himalayas are modifying forest structure and function, notably biogeographical changes in tree species distribution together with alteration in Net Primary Production (NPP), Leaf Area Index (LAI) and Carbon biomass. These alterations are most pronounced in mountain environments, carrying significant impacts on woody species which
The Covid-19 crisis presents an opportunity to evaluate the effectiveness of fiscal policy by investigating how fiscal stimuli aided recovery from the pandemic in Sweden. As Covid-19 have led to increased concerns of unsustainable debt levels, questions of how government spending has affected the economic rebound and fiscal sustainability arises. To tackle these questions, I evaluate pre-existing
The Baltic Sea is one of many aquatic ecosystems that show long-term declines in dissolved silicate (DSi) concentrations due to anthropogenic alteration of the biogeochemical Si cycle. Reductions in DSi in aquatic ecosystems have been coupled to hydrological regulation reducing inputs, but also with eutrophication, although the relative significance of both processes remains unknown for the observ
Background: The global plant-based food shift puts high pressure on manufacturing capacity at facilities like Oatly's Landskrona site. This environment faces high combinatorial complexity due to growing product variety and sequence-dependent cleaning requirements. Relying on manual, experience-based planning to navigate these rules limits throughput and introduces organisational risk. Purpose
Childhood cancer aetiology is poorly understood and is considered to originate in utero and early postnatal life. In this study, we investigated perinatal characteristics as potential risk factors by performing a population-based case-control study, including 1340 cancer cases diagnosed < 19y and born between 1989–2021 in southern Sweden, and 13400 controls matched by sex, year, and municipality o
