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Previous in vitro and case–control studies have found an association between the insulin-like growth factor (IGF)-axis and bladder cancer risk. Circulating concentrations of IGF-I have also been found to be associated with an increased risk of several cancer types; however, the relationship between pre-diagnostic circulating IGF-I concentrations and bladder cancer has never been studied prospectiv
Background: It has previously been reported that venous cannulation-induced pain (VCP) can be used to predict acute postoperative pain after laparoscopic cholecystectomy. Patients rating VCP at ≥2.0 VAS units had 3.4 times higher risk for moderate or severe pain. The purpose of this study was to evaluate if VCP scores of ≥2.0 VAS units are associated with higher risk for acute postoperative pain a
The aim of this research project was to create a bioinformatic image analysis pipeline for the investigation of lymphocytes in healthy human lungs. The lung is an important organ to study as it provides a fast way for pathogens to enter the body. Therefore, the pulmonary immune system must be further investigated in both healthy and diseased tissue. In order to do comparative studies, we need to c
Nowadays, many evacuation models exist in the market, and new models are continuously released with new features. How to assess the usability and reliability of model results becomes an issue for both developers and users. Therefore, verification and validation (V&V) protocols were introduced in the assessment process of evacuation models. To conduct V&V of a model, a widely accepted test
Introduction: Cytostatic pharmaceuticals are increasingly detected in the aquatic environment, raising concerns due to their persistence and toxicity. Background: Conventional wastewater treatment processes do not effectively remove these compounds. Advanced oxidation processes, such as ozonation, are needed to degrade cytostatic pharmaceuticals during wastewater treatment. However, these process
This thesis investigates the causal impact of sponsored academy conversion on educational outcomes in English secondary schools, focusing specifically on the proportion of pupils achieving a standard pass in both English and mathematics at the end of Key Stage 4. Using a panel dataset of secondary schools from 2011 to 2019, and a two-way fixed effects staggered difference-in-differences (DiD) appr
Introduction: Omega-3 fatty acid supplements are widely used as an alternative to eating oily fish. However the polyunsaturated oils they contain are highly susceptible to oxidation, which can lead to rancidity and possibly decreased quality of the supplement. Background: Despite the convenience of omega-3 supplementation, there is limited independent information on the oxidative quality of produ
The aim of the study was to investigate whether work-study conflict and study-work conflict predict perceived stress and well-being in full-time university students who work part-time, and whether perceived stress predicts well-being. The study was conducted with a quantitative cross-sectional design where data were collected through a web-based questionnaire where participants answered establishe
Objectives To assess the performance of the ALL IN TRIPLEX rapid antigen-based test for SARS-CoV-2, influenza A, influenza B, and respiratory syncytial virus. We focus on the potential of the test to be used in acute clinical settings as a marker of infectiousness, by determining the sensitivity at different real-time PCR cycle threshold (Ct) levels, as well as the quantity of absorbed viral RNA n
The genetic causes of familial breast cancer are still unclear, where only less than 20% have evident germline mutations. Most studies focus on mutations that cause a direct impact in the protein, disregarding the synonymous variants, where the codon is changed but the amino acid encoded remains the same. Synonymous variants can affect mRNA stability and translation, by differences in codon usage
OBJECTIVE-This study assessed insulin and glucagon secretion in relation to insulin sensitivity in Caucasian women who develop impaired glucose tolerance (IGT) versus those who maintain normal glucose tolerance (NGT) over a 12-year period. RESEARCH DESIGN AND METHODS-At baseline and after 3, 8, and 12 years, glucose tolerance (75-g oral glucose tolerance test), insulin sensitivity (euglycemic-hype
Accurate and internationally comparable Human Papillomavirus (HPV) DNA genotyping is essential both for evaluation of HPV vaccines and for effective monitoring and implementation of vaccination programs. World Health Organisation (WHO) HPV Laboratory Network (LabNet) regularly issues international proficiency studies. The 2010 HPV genotyping proficiency panel for HPV vaccinology contained 43 coded
Objective: To determine whether preterm birth is associated with epilepsy in a national cohort of adults aged 25-37 years. Methods: We conducted a national cohort study of 630,090 infants born in Sweden from 1973 through 1979, including 27,953 born preterm (< 37 weeks), followed from 2005 to 2009 for 1) hospitalization for epilepsy and 2) outpatient and inpatient prescription of antiepileptic drug
The common genetic variants associated with complex traits typically lie in noncoding DNA and may alter gene regulation in a cell type-specific manner. Consequently, the choice of tissue or cell model in the dissection of disease associations is important. We carried out an expression quantitative trait loci (eQTL) study of primary human osteoblasts (HOb) derived from 95 unrelated donors of Swedis
Germline BRCA1 mutations predispose to breast cancer. To identify genetic modifiers of this risk, we performed a genome-wide association study in 1,193 individuals with BRCA1 mutations who were diagnosed with invasive breast cancer under age 40 and 1,190 BRCA1 carriers without breast cancer diagnosis over age 35. We took forward 96 SNPs for replication in another 5,986 BRCA1 carriers (2,974 indivi
Background: Studies from Sweden have reported association between immigrant status and incidence of cardiovascular diseases. The nature of this relationship is unclear. We investigated the relationship between immigrant status and risk of heart failure (HF) hospitalization in a population-based cohort, and to what extent this is mediated by hypertension and life-style risk factors. We also explore
Objective: To analyse if predictors of radiographic progression differ between patients treated with or without prednisolone in early rheumatoid arthritis (RA). Radiographs of hands and feet were assessed using the modified Sharp/van der Heijde score and radiographic progression was defined as an increase in the total Sharp score above 5.8 (the smallest detectable change). Design: Prospective, ran
