Filtyp
Pathway-specific therapy is the future of cancer management. The oncogenic phosphatidylinositol 3-kinase (P13K) pathway is frequently activated in solid tumors; however, currently, no reliable test for P13K pathway activation exists for human tumors. Taking advantage of the observation that loss of PTEN, the negative regulator of P13K, results in robust activation of this pathway, we developed and
The analysis of Helicobacter pylori proteins is a demanding task for the elucidation of virulence factors, antigens and vaccines, all important for diagnosis, therapy and protection. In the "pre-genomic era" the purification of proteins was mostly performed by using various techniques such as detergent treatment of the bacterial cells, ultra-centrifugation, various chromatographic methods, antibod
BACKGROUND. Prostate specific antigen (PSA) is widely used for prostate cancer screening but its levels are influenced by many non cancer-related factors. The goal of the study is to estimate the effect of genetic variants on PSA levels. METHODS. We evaluated the association of SNPs that were reported to be associated with prostate cancer risk in recent genome-wide association studies with plasma
Linear pi-conjugated oligomers have been widely investigated, but the behavior of the corresponding cyclic oligomers is poorly understood, despite the recent synthesis of pi-conjugated macrocycles such as [n]cycloparaphenylenes and cyclo[n]thiophenes. Here we present an efficient template-directed synthesis of a pi-conjugated butadiyne-linked cyclic porphyrin hexamer directly from the monomer. Sma
The present study is composed of a series of six independent yet related articles treating various aspects of international trade and economic growth. In Chapter two the effects of European Integration (EI) on long-run economic growth is studied. Contrary to earlier empirical results long-run effects of EI are identified. As a development Chapter three examines two potential channels linking EI to
Popular Abstract in Swedish Sedan 1981, då de första fallen av AIDS beskrevs, har 25 miljoner människor dött på grund av att de har blivit smittade av immunbristviruset HIV . Det finns idag mer än 40 miljoner människor som lever med HIV eller AIDS. SIV är apsläktets variant på HIV och orsakar normalt ingen sjukdom hos sina värddjur som är olika afrikanska apor, men då asiatiska apor, t. ex. makakeSimian immunodeficiency virus (SIV) infections in macaques are commonly used as models to study the pathogenesis of human immunodeficiency virus (HIV). Both SIV and HIV normally use the CD4 receptor and an additional coreceptor for cell entry. The most common coreceptors used by HIV are CCR5 and CXCR4. SIV use CCR5 and rarely CXCR4 but may use other coreceptors as alternatives. We have studied vi
In vision-based feedback control systems, the time to obtain sensor information is usually non-negligible, and these systems thereby possess fundamentally different timing behavior compared to standard real-time control applications. For many image-based tracking algorithms, however, it is possible to trade-off the computational time versus the accuracy of the produced position/orientation estimat
The electronic structure of GaAs (100) grown by low-temperature molecular beam epitaxy was investigated by means of photoemission spectroscopy. Slight differences are found in the valence band spectra of GaAs layers grown at different As-2/Ga flux ratios. Analysis of As 3d core level spectra does not indicate qualitative differences in respect to high temperature grown GaAs (100) layers. The Ga 3d
In this study, we describe the expression and function of CD40, a TNF receptor family member, in cervical carcinomas. CD40 was present at very low levels in normal cervical epithelium but was overexpressed in human papillomavirus-infected lesions and advanced squamous carcinomas of the cervix. The stimulation of CD40-positive cervical carcinoma cell lines with soluble CD40L (CD154) resulted in act
Popular Abstract in Swedish Föreliggande avhandling, I litteraturens mittfåra, behandlar bokmarknad, bokklubbar och litteraturen under 1970-talet i Sverige. Bakgrunden till undersökningen är de radikala förändringar som skedde på den svensk bokmarknaden efter den genomgripande avregleringen av handeln med böcker 1970. Bokklubbarna växte från att inneha en marknadsandel på 9% 1970 till att ha 30% aThe present dissertation, I litteraturens mittfåra, deals with book trade, book clubs, and the fiction prose of the 1970s in Sweden. The background to the study is the radical change in Swedish book trade through a far-reaching deregulation of the trade in 1970. The book clubs expanded from a position where they held a 9% share of the market in 1970 to a market share of 30% in 1980.And the specifi
Popular Abstract in Swedish Vårtor (skivepitelpapillom) i hud eller slemhinna orsakas av papillomvirus. Kunskapen om detta virus var länge ganska liten eftersom det inte går att odla i cellkulturer, men med molekylärbiologins framsteg har förståelsen ökats. Varje djurart har sina egna papillomvirus och genom att jämföra nukleinsyrasekvenserna i DNA-kedjan hos olika virusisolat har man identifieratThe occurrence of genital human papillomavirus infection was determined in different categories of patients by means of PCR. In high proportion of young women attending an adolescent clinic, the presence of HPV DNA was demonstrated in simultaneously urethral and cervical samples, suggesting that genital HPV infections are often multifocal. Multiple HPV types were demonstrated in about half of the
Microelectronics promises a high component density and low power dissipation to embedded systems. Unfortunately such a component will always suffer from various error types that make the chip respond differently from its functional simulation. This is especially true for Cellular Neural Networks (CNN), which makes the determination of robust, low-precision parameters to guarantee small footprint a
The stabilization characteristics and local extinction structures of partially premixed methane/air flames were studied using simultaneous OH-PLIF/PIV techniques, and large eddy simulations employing a two-scalar flamelet model. Partial premixing was made in a mixing chamber comprised of two concentric tubes, where the degree of partial premixing of fuel and air was controlled by varying the mixin
Collagen-induced arthritis (CIA) is a T cell-dependent autoimmune disease that serves as an animal model for human rheumatoid arthritis. CIA can be induced in H-2q mice by a single immunization with the cartilage-specific protein type II collagen (CII). This study has focused on CII immunity and tolerance with respect to the interactions between antigen, antigen-presenting cells and T cells. CIA-r
Abstract in UndeterminedPurposeThe purpose of this article is to explore and classify themes and challenges in making urban freight distribution sustainable.Design/methodology/approachThe study has a cross sectional design which started by a narrative literature review and analysis of a sample of related literature (like peer-reviewed articles and EU (European Union) documents). It ended with comp
Popular Abstract in Swedish Den moderna epokens början återfinns i det sena sjuttonhundratalet och i Europa. Det är en epok, en kultur som förstår sig som både ny och som annorlunda i förhållande till tidigare epoker och kulturer, sådana som vilat på myter, religion och tradition. Den nya kulturens fundamentala insikt bestod i att ingenting måste vara så som det är, utan allt vore möjligt också påThe problem which the present study discusses is modernity. The study interprets modernity’s cultural and anthropological dispositions as historical appearances. Consequently, it is situated at the intersection of cultural sociology and historical anthropology. The aim is to generate insight and understanding rather than a coherent theory. The key element consists of combination and variation of c
Popular Abstract in Swedish Materien strävar efter största möjliga oordning (entropi). Det krävs ett aktivt ingripande (energitillskott) för att ordna och separera saker. Har man väl hällt salt i teet är det svårt att ta bort, och byta ut det mot socker. Vid framställningen av olika ämnen får man ofta ut en blandning som även innehåller sådant man inte vill ha, och måste hitta sätt att skilja dem The purification of proteins from raw materials like fermentation broth and other biological sources usually involves several purification steps and is rather time consuming and expensive. This is a major concern in the production of many important protein products e.g. pharmaceuticals such as insulin and blood coagulation factors. One way to speed up the isolation of protein from particle-contai
