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Low- and high-dose infections with the murine large intestinal nematode Trichuris muris are associated with induction of adaptive Th1 and Th2 responses, respectively, in mesenteric lymph nodes (MLN). Classical dendritic cells (cDC) accumulate in the large intestinal mucosa and MLN upon T. muris infection, yet their role in driving adaptive responses to infection remains largely unknown. We perform
Background Worse outcomes have been noted in patients with multiple primary melanomas (MPMs) than in patients with single primary melanomas. Objective We investigated how family history of melanoma and germline CDKN2A mutation status of MPM patients affects risks of developing subsequent melanomas and other cancers and survival outcomes. Methods Comprehensive data on cancer diagnoses and deaths of
Galectin-3 is an endogenous β-galactoside-binding lectin comprising a carbohydrate recognition domain (CRD) linked to a collagen-like N-domain. Both domains are required for galectin-3 to induce cellular effects; a C-terminal fragment of galectin-3, galectin-3C, containing the CRD but lacking the N-domain, binds cell surface glycoconjugates but does not induce cellular effects since cross-linking
Parasites are expected to exert long-term costs on host fecundity and longevity. Understanding the consequences of heritable polymorphic variation in disease defence in wild populations is essential in order to predict evolutionary responses to changes in disease risk. Telomeres have been found to shorten faster in malaria-diseased individuals compared with healthy ones with negative effects on lo
Objectives To describe the incidence of atrioventricular (AV) block II-III, atrial fibrillation (AF), pacemaker implantation (PM) and aortic regurgitation in patients with ankylosing spondylitis (AS), undifferentiated spondyloarthritis (uSpA) and psoriatic arthritis (PsA) compared with the general population (GP) and with each other. Methods A prospective nationwide study with cohorts of patients
The Roman historian Tacitus is not only our most important source for the Early Roman Empire, but also a literary artist second to none. His fragmentarily preserved Annales deals with the imperial rule established by the first emperor Augustus, the Julio-Claudian dynasty (AD 14 – 68). Through his scathing analyses of the consequences of autocratic government, Tacitus has established himself as an
Over the past few decades, lean management philosophies have penetrated various sectors of industry. At same time, dynamic environmental, or green, management is needed to succeed in the current green conscious market. Some research has already been conducted on the potential synergy gains of the two management philosophies, since both are known to strive towards efficient use of resources, elimin
Aim: To assess Ig20Gly tolerability in pediatric patients with primary immunodeficiencies. Patients & methods: Infusion parameters and tolerability were analyzed in pediatric patients (aged 2-5 years [n = 6], 6-11 years [n = 22] and 12-17 years [n = 22]) receiving Ig20Gly in two Phase II/III trials. Results: Of 2624 Ig20Gly infusions, >99% did not require any rate reduction, interruption or di
During a metal cutting process, chemical wear can become the dominant mechanism of tool degradation under the high temperatures and contact pressures that arise between the tool and the metal workpiece. This study focuses on the chemical and diffusional interactions between superalloy Inconel 718 and cubic boron nitride (cBN) tool material with and without TiC binder. It covers thermodynamic model
In recent years, machine learning has evolved in a fast pace as both algorithms and computing power are constantly improving. In this study, a machine learning model for predicting the fuel oil consumption from engine data has been developed for a cruise ship operating in the Baltic Sea. The cruise ship is equipped with legacy volume flow meters and newly installed mass flow meters, as well as an
We demonstrate the manipulation of single-walled carbon nanotube/liquid crystal composites using in-plane electric fields. The conductivity of the materials is shown to be dependant on the application of a DC bias across the electrodes. When the materials are subjected to this in-plane field, it is suggested that the liquid crystals orientate, thereby forcing the SWCNTs to follow in alignment. Thi
Previously established immunogenic (tum-) clones of an ENU (ethyl-N-nitrosourea)-induced rat glioma, N32, were compared to the original tumor concerning their capacity to induce T lymphocyte responses after in vivo immunization and in vitro restimulation of responder spleen cells in mixed lymphocyte tumor culture (MLTC) assays. Quite unexpectedly, original N32 (tum+) in vivo primed spleen cells pr
Human papillomavirus type 16 (HPV16) is a cancer-causing virus that contributes to at least 70% of cervical cancer as well as to other anogenital cancers and head and neck cancer. Understanding HPV16 gene regulation is important to enhance our understanding of HPV16 infections and may contribute to development of antiviral drugs. In this study, we show that nucleosides/nucleoside analogues have th
Background The impact of baseline anemia in a contemporary acute coronary syndrome (ACS) population undergoing percutaneous coronary intervention in the era of predominant radial artery access, potent P2Y12 inhibition, and rare use of glycoprotein IIb/IIIa inhibitors has not been adequately studied. Methods and Results ACS patients who underwent percutaneous coronary intervention between 2014 and
Organic carbon burial in lake sediments plays an important role in the global carbon cycle, and is heavily affected by the terrestrial organic matter input. However, few studies have focused on long-term changes in terrestrial organic matter input to lakes in response to land-use changes. The aim of this study was to assess variations in sedimentary terrestrial organic matter over the last 1000 ye
In this contribution we present some preliminary results on the dynamical evolution of two planet systems around stellar hosts evolving from the main sequence to the white dwarf phase. The aim is to study the instabilities triggered by stellar evolution that may bring planets onto the stellar surface or produce planetary scale collisions (hence debris) that could explain the metallic atmospheric p
