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The HAMLET family of compounds (Human Alpha-lactalbumin Made Lethal to Tumours) was discovered during studies on the properties of human milk, and is a class of protein-lipid complexes having broad spectrum anti-cancer, and some specific anti-bacterial properties. The structure of HAMLET-like compounds consists of an aggregation of partially unfolded protein making up the majority of the compound'
The complement system is activated in the vasculature during thrombotic and inflammatory conditions. Activation may be associated with chronic inflammation on the endothelial surface leading to complement deposition. Complement mutations allow uninhibited complement activation to occur on platelets, neutrophils, monocytes, and aggregates thereof, as well as on red blood cells and endothelial cells
We have investigated the initial oxidation of the Rh(113) and Rh(223) vicinal surfaces by STM and ab initio simulations. Upon adsorption of small amounts of oxygen, the surface morphology is completely altered. Surprisingly, oxygen-stabilized Rh adatoms can be observed on the (113) facets, with oxide-like electronic properties. We present models of these "0D oxide" phases and discuss reasons for t
Antineutrophil cytoplasm autoantibodies (ANCA) directed against bactericidal/permeability-increasing protein (BPI) are common in patients with cystic fibrosis (CF), and serum levels are correlated with lung colonization by Pseudomonas aeruginosa and the severity of lung damage. The production of BPI-ANCA may be due to the costimulation of BPI when mounting an immune response against P. aeruginosa.
Swedish has – like other Germanic languages – flexible stress placement, which underlies morphological rules and is also based on the individual word’s origin. The achievement of the correct usage when learning Swedish is challenging. As second language learners of Swedish in the classrooms present speakers of a variety of first languages (L1s), the opportunity has been taken to have a closer look
Popular Abstract in Swedish I denna studie undersöks femtonhundratalets reformatoriska mässa i Sverige och hur den utformades i sockenkyrkorna. Bruk och texter som de reformatoriska källorna vittnar om eller enbart antyder, relateras till de senmedeltida förutsättningar som rådde på sockennivå vid tiden för de första reformatoriska förändringarna av liturgin. Detta tillvägagångssätt lyfter fram deThis study investigates the 16th century Mass of the Reformation in Sweden, with emphasis on how it was celebrated in parish churches. Practices and texts which the sources of the Reformation give evidence of (or merely suggest) are related to the late medieval practices and texts which were in use in the parishes when the reforms began. This method emphasizes continuity and plurality, but also al
The paper is based on a general conceptual supply chain flow risk model developed in an earlier paper, a literature review and case studies. The paper has the title "Developing a supply chain risk model" and is reported as a final paper at the NOFOMA 2005 conference. The literature review has been focusing articles and reports/books on supply chain management. Some of its findings have earlier bee
Extending the product development process to also include the concurrent design of product and packaging is expected to increase efficiency and effectiveness in the development process. Apart from the obvious advantage of reducing the lead times of the development project, improving environmental impact by reducing the consumption of raw material due to the possibility of facilitating a "tailor ma
Deterioration of concrete structures is a worldwide problem. Environmental exposure is known to affect concrete strength in structures. While moisture affects rebound values by lowering them, carbonation does the opposite. The aim of the study was to determine the in-situ concrete strength of three bridge elements, namely, pier, abutment and deck and evaluate the environmental conditions such as m
Popular Abstract in Swedish När vi drabbas av infektioner är det immunförsvaret som ser till att de invaderande organismerna oskadliggörs. För att immunförvaret skall veta vilka organismer och celler som skall attackeras måste det kunna skilja på kroppseget och främmande. En del främmande organismer lever antingen i symbios med den egna kroppen eller så utgör de inget hot. Teoretiskt sett är mat kThe immune response is designed to protect the body from harmful microbial invasions. However, when the immune system attacks itself instead, an autoimmune reaction starts that damage our own cells, tissues and organs. Despite decades of research concerning the etiology of autoimmune diseases the molecular mechanisms of these disorders are poorly understood as they are complex and influenced by bo
Popular Abstract in Swedish Under de senaste decennierna har det pågått en intensiv kamp om dramapedagogikens innehåll. Den har i betydande utsträckning förts på nordiskt plan. Dramaläraren och lärarutbildaren Viveka Rasmusson visar att denna debatt om dramaämnet och dess utveckling med fördel kan studeras i den nordiska tidskriften Drama. Under större delen av sjuttiotalet var Drama ett gemensamtBased on the Nordic dramapedagogic journal Drama during the period 1965-1995 the thesis analyses Nordic dramapedagogy and the dramatheoretical debate of the subject drama, which entered Nordic school curriculums in the sixties and the seventies. During the period a struggle was fought by predecessors from different aestethic and pedagogical directions concerning the definition of the subject. The
The present study was designed to describe the pattern of long-term formal support received by people with mental disorders, and to investigate the relationship between the medical, psychological and social characteristics of the participants and types of formal support. This study is based on a cohort (n = 192) of people born in 1902 and 1903 in a community in Southern Sweden. The research partic
The involvement of Helicobacter pylori in the pathogenesis of extragastric diseases continues to be an interesting topic in the field of Helicobacter-related pathology. Although conflicting findings have been reported for most of the disorders, a role of H. pylori seems to be important especially for the development of cardiovascular and hematologic disorders. Previously isolated human and animal
The structure and dynamics of a turbulent partially premixed methane/air flame in a conical burner were investigated using laser diagnostics and large-eddy simulations (LES). The flame structure inside the cone was charecterized in detail using LES based on a two-scalar flamelet model, with the mixture fraction for the mixing field and level-set G-function for the partially premixed flame front pr
Antibody microarray is a rapidly emerging, powerful approach with great promise within high-throughput proteomics. However, before a truly proteome-wide analysis can be performed, the antibody array format needs to be miniaturized even further in order to enable ultradense arrays to be fabricated. To this end, we have designed and generated proof-of-concept for the first generation of an atto-vial
