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Background: In Europe, approximately 291,000 cardiac arrests occur annually. Despite critical care therapy, hospital mortality remains high. This systematic review assessed whether, in comatose survivors of cardiac arrest, any drug therapy, compared to placebo or usual care, improves outcomes. Methods: We searched Medline, EMBASE, the Cochrane Central Register of Controlled Trials, and The Interna
Background: Interleukin-6 is dysregulated in multiple pathological conditions, e.g., cancer and inflammatory diseases. Aim: To investigate new mechanisms for the regulation of pathological IL-6 production. Methods: PBMCs (peripheral blood mononuclear cells) stimulated by cancer serum factors or specific peptides produce interleukin-6 (IL-6). Immunoregulatory albumin neo-structures and peptides wer
The present study examines the discussions about alliance policy in the Swedish council of the realm 1680-1683. Taking issue with earlier research that has portrayed the Swedish foreign policy during this period in realist terms, the study instead uses the concepts of friendship, status and sovereignty to give context to the arguments used by the council when discussing alliance partners. Regardin
We describe the transmission of hepatitis C virus (HCV) to two patients from a thoracic surgeon who was unaware of his hepatitis C infection. By partial sequencing of the non-structural 5B gene and phylogenetic analysis, the viruses from both patients were found to be closely related to genotype la strain from the surgeon. Two further hepatitis C cases were found in relation to the thoracic clinic
Specific inhibition of the entry of encephalitogenic T lymphocytes into the central nervous system in multiple sclerosis would provide a means of inhibiting disease without compromising innate immune responses. We show here that targeting lymphocyte interactions with endothelial basement membrane laminins provides such a possibility. In mouse experimental autoimmune encephalomyelitis, T lymphocyte
Four new Caloplaca species with depsidones are described, C. ochrolechioides S.Y. Kondr., Kärnefelt & Elix, with variolaric and isosubnotatic acids, C. phaeocincta S.Y. Kondr. & Elix, C. sconensis S.Y.Kondr., Kärnefelt & A.Thell, and C. tomnashii S.Y. Kondr., Elix & Kärnefelt, with caloploicin, vicanicin, diploicin, fulgidin, and isofulgidin. The new combination Crocynia glaucescen
The generation of mathematical models of biological processes, the simulation of these processes under different conditions, and the comparison and integration of multiple data sets are explicit goals of systems biology that require the knowledge of the absolute quantity of the system's components. To date, systematic estimates of cellular protein concentrations have been exceptionally scarce. Her
In birds, molt duration is an important trait that can affect plumage functionality and, consequently, the fitness of individuals. However, knowledge about the factors that affect variation in molt speed is sparse, mostly because of the methodological difficulties of studying avian molt. We used a ptilochronology-based approach to estimate the rate at which tail feathers were produced during molt
Ur ett hundraårsperspektiv har arbetsmarknaden genomgått avsevärda förändringar. Majoriteten av löntagarna utgörs numera av tjänstemän. I Sverige svarar de även för majoriteten av fackmedlemmarna. De svenska fackföreningarna tillämpade redan tidigt en bred medlemsrekrytering, men till bilden hör också att Sverige har världens mest klassuppdelade fackliga rörelse. Inte minst för tjänstemännen har d
System identification of linear multivariable dy-namic models based on discrete-time data can be performed using a algorithm combining linear regression and LQG-balanced model reduction. The approach is applicable also to unstable system dynamics and it provides balanced models for optimal linear prediction and control.
This thesis investigates the financial viability of green hydrogen production for mobility applications across four European countries: Germany, Norway, Denmark and Spain. Given the rising importance of hydrogen in hard-to-electrify sectors such as (heavy-duty) transport, the study focuses on understanding how system design and local energy conditions influence the Levelised Cost of Hydrogen (LCOH
This thesis argues that the escalating and protracted violence in Mexico, commonly known as the ‘war on drugs,’ constitutes a non-international armed conflict (NIAC) under international humanitarian law (IHL), calling for a formal application of this legal framework. Despite its devastating humanitarian consequences, the conflict is often mischaracterised within a law enforcement paradigm, contrib
The thesis shows how different aspects of sustainable development have been handled or not handled in the third generation infrastructure development in Sweden. The difference between the design of the 3G development - emphasizing competition, growth and regional access, based on a strong technological optimism - and the implementation, as the roll out struck the landscape, including the non-handl
Dendritic cells present microbial antigens to T cells after uptake of apoptotic vesicles from infected cells. We previously reported that immunizations with apoptotic HIV-1/murine leukemia virus (MuLV) infected cells lead to induction of both cellular and humoral immune responses as well as resistance to mucosal challenge with live HIV-1/MuLV infected cells. Here we extended those studies and inve
Background: Many strategies are currently being pursued in order to generate mature dendritic cells (DC) to be used for immunotherapy. A potent anti-tumour influence by extracorporeal photopheresis has been documented for cutaneous T-cell lymphoma, and a major mechanism of action has been suggested to be generation of DC presenting tumour antigens. Purpose: To determine the potential of a simple c
Purpose: The 2021 guidelines endorsed by the European Resuscitation Council (ERC) and the European Society of Intensive Care Medicine (ESICM) recommend using highly malignant electroencephalogram (EEG) patterns (HMEP; suppression or burst-suppression) at > 24 h after cardiac arrest (CA) in combination with at least one other concordant predictor to prognosticate poor neurological outcome. We evalu
