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Interleukin-15 (IL-15) is a cytokine that has been shown to expand CD8 T cell and natural killer (NK) cell populations, and therefore has potential for potentiating adoptive immune cell therapy for cancer. Previously, IL-15 has been shown to induce proliferation of CD8 memory T cells through activation of telomerase. Here, we investigated whether telomerase is also activated during the IL-15 media
This work presents a new polyester binder based on 2,5-furandicarboxylic acid (FDCA) as precursors of polyurethane (PU) coatings. The new 100% bio-based structure is composed of four different monomers such as glycerine (Gly), 1,3-propanediol (1,3-PD), 2,5-furandicarboxylic acid (FDCA) and succinic acid (SA). The corresponding PU coating was obtained by crosslinking with a conventional polyisocyan
Transcription factors normally regulate gene expression through their action at sites where they bind to DNA. However, the balance of activating and repressive functions that a transcription factor can mediate is not completely understood. Here, we showed that the transcription factor PU.1 regulated gene expression in early T cell development both by recruiting partner transcription factors to its
Background: The absence of interleukin-25 (IL-25) favors the induction of Th1 and Th17 immune responses in mice. Th1 immune responses have been associated with the pathology of atherosclerosis, a lipid and inflammation driven disease of the arterial wall. Purpose of research: To evaluate the effect of IL-25 on human peripheral blood mononuclear cells (hPBMCs) in the presence and absence of oxidize
Spotted fever group (SFG) Rickettsia species are inoculated into the mammalian bloodstream by hematophagous arthropods. Once in the bloodstream and during dissemination, the survival of these pathogens is dependent upon the ability of these bacteria to evade serum-borne host defenses until a proper cellular host is reached. Rickettsia conorii expresses an outer membrane protein, Adr1, which binds
Premature prelabor rupture of the fetal membranes affects about 3% of pregnancies. The cause is usually infection, especially at earlier gestations. The prognosis and the risks of delivery are both much worse at earlier gestations. Before viable pregnancy, termination may be offered. Once the fetus is viable, steroids to mature the fetal lungs and antibiotics to reduce infection are the mainstays
This chapter introduces the volume by presenting the questions of politics and ethics of representation in qualitative research. It also shows how these are approached in the following chapters through analyses of moments of discomfort in our research practice. We situate our work in critical, feminist and engaged scholarship and discuss how creating representation in qualitative research is linke
The structural set-up and key characteristics of regulatory regimes for risk management vary between countries, technical domains and application areas. Risk regulations come in different forms, ranging from a highly prescriptive (“hard”) approaches including explicit requirements on key risk management components, to “softer” approaches requiring risk to be managed without defining how. Risk regu
OBJECTIVE: The aim of the study was to investigate the associations of total sleep time (TST) and occupational stress based on the Brief Job Stress Questionnaire (BJSQ) with cholesterol levels in an occupational cohort of Japanese office workers. METHODS: The present study is a secondary analysis of a subset of participants from a randomized controlled trial. Participants were 179 employees from 5
This chapter examines the evolution of social class segregation in the city of Landskrona during the twentieth century. The city’s population was initially spatially mixed with regards to social class but became more segregated with industrialization. The study reveals that the segregation of higher white-collar workers increased drastically from 1940 to 1960, with a concentration of this group in
BACKGROUND: Little is known about risks of hypertensive disorders of pregnancy in both first-and second-generation immigrant women in Europe and other Western countries; such knowledge may help elucidate the influence of genetic versus social factors on such risks. We aimed to study both first-and second-generation immigrant women for the presence of all types of hypertension (preexisting hyperten
Purpose: This paper aims to challenge the view of Sweden’s climate leadership by problematizing its domestic climate adaptation governance and highlighting the need for a more holistic view of adaptation. The paper highlights aspects that are troublesome for not only the built environment along coastlines but also the future of Sweden’s standing as a climate leader. The paper concludes with recomm
Younger generations in South Korea are increasingly concerned about environmental issues, while youth climate activism is one of the fastest growing social movements globally, engaging formal and informal politics at multiple levels. Among others, Youth 4 Climate Action, a Korean youth climate movement group, has initiated climate change litigation and presented its actions at a side event of the
Today, many control applications in cyber-physical systems are implemented on shared platforms. Such resource sharing may lead to complex timing behaviors and, in turn, instability of control applications. This paper highlights a number of anomalies demonstrating complex timing behaviors caused as a result of resource sharing. Such anomalous scenarios, then, lead to a dramatic increase in design c
