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Osteoporosis has been recognized as a major public health problem for less than two decades. The increasing incidence of fragility fractures, such as vertebral, hip, and wrist fractures, first became apparent from epidemiological studies in the early and mid-1980s, when effective treatment was virtually unavailable. Pharmacological therapies that effectively reduce the number of fractures by impro
We have identified for the first time an age-dependent spontaneous loss of tolerance to two self-antigenic epitopes derived from putative diabetes-associated antigens glutamic acid decarboxylase (GAD65) and glial fibrillary acidic protein (GFAP) in RIP-B7/DRB1*0404 HLA transgenic mice. Diabetic and older non-diabetic mice exhibited a proliferative response to an immunodominant epitope from GAD65 (
BACKGROUND: We measured serum levels of human glandular kallikrein 2 (hK2) in patients treated with radical retropubic prostatectomy (rrP) for clinically localized prostate cancer (PCa) with a total PSA (tPSA)-level below 10 ng/ml to investigate whether hK2 can be applied to preoperatively distinguish organ-confined (pT2a/b) from nonorgan-confined (> or = pT3a)-PCa more accurately than total PSA.
Combretastatin A-4 disodiumphosphate (CA4P), a prodrug formulation of the natural product combretastatin A-4 (CA4), is currently in clinical investigation for the treatment of cancer. In vivo, CA4P is rapidly enzymatically converted to CA4, a potent inhibitor of tubulin polymerization (IC50 = 1-2 muM), and rapidly causes bloodflow shutdown in tumor tissues. A variety of alkyl and aryl di- and trie
Phosphor thermometry is applied for the first time in a large-bore two-stroke diesel engine. The work proves the practicality of phosphor thermometry in large-bore engines. The experiments were conducted on the MAN 4T50ME-X marine research engine equipped with an optical cylinder head. By employing a thin surface coating of CdWO4 phosphor, cycle resolved temperature measurements of the cylinder wa
Popular Abstract in Swedish Kontaktallergi är en vanlig orsak till eksem i arbetslivet. Ett av de viktigaste arbetsrelaterade allergenen är epoxiharts. Det allergiframkallande ämnet i det vanligaste epoxihartset visades på 1970-talet vara det ämne, diglycidyleter av bisfenol A (DGEBA), som hartset är uppbyggt av. Dessa epoxihartser är sedan decennier med i den standardserie med allergiframkallandeEpoxy resins based on bisphenol A are well-known contact allergens and often cause occupational contact allergy. The most important allergen is the monomer diglycidyl ether of bisphenol A (DGEBA). Epoxy resins of the bisphenol F-type contain 3 isomers of the diglycidyl ether of bisphenol F; p,p'-DGEBF, o,p'-DGEBF, and o,o'-DGEBF, whereas epoxy resin(s) based on bisphenol A (DGEBA-R) contain virtua
Tannerella forsythia is a poorly studied pathogen despite being one of the main causes of periodontitis, which is an inflammatory disease of the supporting structures of the teeth. We found that despite being recognized by all complement pathways, T. forsythia is resistant to killing by human complement, which is present at up to 70% of serum concentration in gingival crevicular fluid. Incubation
Popular Abstract in Swedish Att vara äldre, beroende av hjälp och leva med varaktig smärta. För äldre människor som är beroende av hjälp från omvärlden för att klara av sitt dagliga liv, utgör inte bara den nedsatta funktion ett problem. Många är drabbade även av andra problem, varav ett vanligt är ihållande och varaktig smärta. För vissa äldre med gravt nedsatt funktion kan språket ha drabbat's This thesis explores everyday living with persistent pain from the perspectives of functionally dependent older persons in pain and of staff. A combination of qualitative and quantitative methods was chosen. Data were collected using interviews and tools for assessing pain. The first data collection included 66 persons (65+) living in sheltered accommodation and their corresponding contact nurses.
Popular Abstract in Swedish Denna avhandling beskriver studier av de mekanismer varmed bakterien Streptococcus pyogenes undviker komplementdeposition och fagocytos.Phagocytosis of Streptococcus pyogenes is complement dependent. However, the cell wall-associated M protein, which exists in >100 different serotypes (M types), enables the bacteria to evade phagocytosis. To analyze the mechanisms by which M protein confers this ability we used, as model systems, two representative M proteins, the M22 and M5 proteins, which have properties typical for many M prote
Background Preventive programs for individuals who have high lifetime risks of colorectal cancer may reduce disease morbidity and mortality. Thus, it is important to identify the factors that are associated with hereditary colorectal cancer and to monitor the effects of tailored surveillance. In particular, patients with Lynch syndrome, hereditary nonpolyposis colorectal cancer (HNPCC), have an in
Popular Abstract in Swedish Denna avhandling i tysk språkvetenskap behandlar en särskild typ av meningar i dagens tyska: påståendesatser med det finita verbet i början. Denna typ har hittills knappast uppmärksammats av forskningen; en av anledningarna till detta är att den oftast förekommer i talat språk. Den vanliga ordföljdsregeln i tyskan är att verbet står på andra plats i huvudsatsen, på sisThe aim of this thesis is to describe and explain independent declarative clauses in German which have the finite verb in absolute clause-initial position. They are called verb-first declarative clauses. It is shown that this type of clause can be found in a variety of Germanic languages. There is evidence suggesting that this is a very old type with roots in ancient Indo-European. It has thus ex
Complex product form generation methods have rarely been used within the field of industrial design. The difficulty in their use is mainly linked to constraints – such as functionality, production and cost – that apply to most products. By cou-pling a mathematically described morphology to an optimisation system, it may be possible to generate a complex product form, compliant with engineering and
Following the recommendations drawn after the Commissioning Phase of the ENVISAT satellite in 2002, SCIAMACHY near real time data processors were upgraded to version 5.01 in early 2004. Before public release of the new SCIAMACHY nitrogen dioxide (NO2) vertical column data product, several validation teams investigated its improvement and assessed its geophysical consistency by means of correlative
The birth and development of Gothicist ideas and their use in Spanish-Swedish contacts
Peking drabbades i januari 2013 av en smogkatastrof av aldrig tidigare uppmätt slag. Incidenten, känd som ”Airpocalypse”, blev en världsnyhet och satte mer än någonsin tidigare fokus på stadens omfattande luftföroreningsproblem. Den här uppsatsen redogör för omfattningen av och orsakerna bakom luftföroreningarna i Peking, och visar att stadens luftkvalitet redan på 80-, 90-, och 00-talen på många In January 2013 Beijing was hit with a wave of smog the likes of which have never been recorded before. The incident, known as ”Airpocalypse”, quickly made news across the globe placing focus on the City's immense air quality problem. This paper investigates the extent of and the reasons behind Beijing's air pollution, and goes on to show that the air quality during the 80's, 90's
When selecting for monoclonal antibodies of a desired affinity, affinity chromatography can be a feasible alternative. This is of particular interest when low affinity monoclonal antibodies (dissociation constant (Kd) > 10(-4) M) are screened, as they are not easily recognised by traditional immunoassay procedures. In this study we have evaluated this approach by monitoring low affinity monoclonal
Here, we highlight the potential translational benefits of delivering FLASH radiotherapy using ultra-high dose rates (>100 Gy·s−1). Compared with conventional dose-rate (CONV; 0.07–0.1 Gy·s−1) modalities, we showed that FLASH did not cause radiation-induced deficits in learning and memory in mice. Moreover, 6 months after exposure, CONV caused permanent alterations in neurocognitive end points, wh
Background: The aim of this study was to evaluate the risk of gastric cancer associated with individual or combined glutathione S-transferases (GSTs) polymorphism and their interaction with environmental factors. Materials and Methods: Genotyping by PCR was carried out for 80 cases and controls each for GSTM1, GSTT1, and GSTP1 polymorphism and mapped for gene—environment association studies. The s
Contemporary entrepreneurial education (EE) has global reach and impact, with a growing number of entrepreneurship courses, specializations, and degrees in all parts of the world. There is no longer a question of the significance and demand for EE in the higher education system. At the same time, the interest in scientific knowledge and proven experience of “what works” has accelerated, resulting
Most neoplasia-associated gene fusions are formed through the fusion of the 5′-part of one gene with the 3′-part of another. We here describe a unique mechanism, by which a part of the KMT2A gene through an insertion replaces part of the YAP1 gene. The resulting YAP1::KMT2A::YAP1 (YKY) fusion was verified by RT-PCR in three cases of sarcoma morphologically resembling sclerosing epithelioid fibrosa
