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Vault particles are conserved organelles implicated in multidrug resistance and intracellular transport. They contain three different proteins and non-coding vault RNAs (vRNAs). Here we show that human vRNAs produce several small RNAs (svRNAs) by mechanisms different from those in the canonical microRNA (miRNA) pathway. At least one of these svRNAs, svRNAb, associates with Argonaute proteins to gu
Bone-metastatic, castration-resistant prostate cancer (bmCRPC) represents a lethal stage of the most common noncutaneous cancer in men. The recent introduction of Radium-223 dichloride, a bone-seeking alpha particle (α)-emitting radiopharmaceutical, demonstrates statistically significant survival benefit and palliative effect for bmCRPC patients. Clinical results have established safety and effica
In order to identify the protein responsible for a dopamine peroxidizing activity, previously described in human normal and parkinsonian substantia nigra by our group, we developed non-denaturing polyacrylamide gel electrophoresis conditions, mimicking the characteristic colour in vitro reaction, resulting from cyclic oxidation of dopamine (DA). After separating protein mixtures from human normal
Aim: To evaluate vibration perception thresholds of patients with and without diabetes, before and after surgical carpal tunnel release. of patients with and without diabetes. Methods: In a prospective study, 35 consecutive patients with diabetes and carpal tunnel syndrome were age and gender matched with 31 patients without diabetes having idiopathic carpal tunnel syndrome. Preoperatively, 6, 12
This review aims to provide a comprehensive overview of the in vitro, animal, and clinical studies with the bacterial strain Lactiplantibacillus plantarum 299v (L. plantarum 299v; formerly named Lactobacillus plantarum 299v) published up until June 30, 2020. L. plantarum 299v is the most documented L. plantarum strain in the world, described in over 170 scientific publications out of which more th
Observations of ionized H αgas in high-redshift disc galaxies have ubiquitously found significant line broadening, σH α∼10 -100 km s-1 . To understand whether this broadening reflects gas turbulence within the interstellar medium (ISM) of galactic discs, or arises from out-of-plane emission in mass-loaded outflows, we perform radiation hydrodynamic simulations of isolated Milky Way-mass disc galax
This article applies the history of emotions lens to study the emotions experienced by the ‘comfort women’ in the Japanese Empire. Emotions have been a long-neglected aspect in the study of military sexual violence. The article examines how a mélange of positive and negative emotions enabled those women to exercise some limited agency in a confined and tightly regulated space and, in some rare cas
Several stars show deep transits consistent with discs of roughly seen at moderate inclinations, likely surrounding planets on eccentric orbits. We show that this configuration arises naturally as a result of planet-planet scattering when the planets possess satellite systems. Planet-planet scattering explains the orbital eccentricities of the discs' host bodies, while the close encounters during
Background: A diagnosis of prostate cancer (PC) may cause psychosocial distress not only in a man but also in his intimate partner. However, long-term risks of depression, anxiety, or suicide in partners of men with PC are largely unknown. Methods: A national cohort study was conducted of 121 530 partners of men diagnosed with PC during 1998-2017 and 1 093 304 population-based controls in Sweden.
This chapter aims to explore community energy (CE)—energy communities that are established and run by private citizens—in four Eastern European countries. The chapter first analyses general contextual conditions supporting the diffusion of CE initiatives in the Baltic Sea Region. Subsequently, it reports the findings of four case studies from Estonia, Latvia, Lithuania, and Poland illustrating som
Purpose Competence is a prerequisite to achieve a well-functioning and competitive supply chain (SC). The purpose of this review is to present an integrated view of the published literature on all the aspects and facets of supply chain competence, and to present a framework for classification and analysis to facilitate further study, practice and research. Design/methodology/approach A structured
The authors discuss CCTV, which is now established as a mature and ubiquitous technology. They review existing research on CCTV as backdrop to introduce an alternative re-narration that stresses its use as an advanced information technology—a socio-technology. Central to this perspective is the recognition that system effectiveness hinges on a match of individual, organizational and technological
The damage caused by a dramatic worldwide increase in so-called natural disasters is staggering, with the poor in developing countries being most at risk. This paper analyses: (a) the key variables and their causal relations that underlie the complex system of risk and disaster occurrence in slums; (b) the impacts of disasters on slums; (c) the strategies used by local people to cope with risk and
Artificial neural networks (ANNs) are nonlinear pattern recognition techniques that can be used as a tool in medical decision making. The objective of this study was to develop an ANN model for predicting survival in patients with pancreatic ductal adenocarcinoma (PDAC).
