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The Web Accessibility Directive (WAD) is part of the European Union’s work for digital inclusion. The WAD obligates that public sector bodies’ websites meet accessibility standards and provide an accessibility statement on the website informing about inaccessible content, and a feedback mechanism for reporting accessibility issues or requesting inaccessible content in an accessible format. The obj
Gene amplification is a crucial process in cancer development, leading to the overexpression of oncogenes. It manifests cytogenetically as extrachromosomal double minutes (dmin), homogeneously staining regions (hsr), or ring chromosomes (r). This study investigates the prevalence and distribution of these amplification markers in a survey of 80 131 neoplasms spanning hematologic disorders, and ben
This study deals with segmental articulations based on acceleration signals from EMA data. We test how well the one-to-one relationship between acceleration peaks and segment boundaries (as described within the framework of the Descriptive Approach to Segmental Articulations) works across different prosodic levels in Swedish, here: focused and unfocused position, with the assumption of a positive
In this article we analyse the actions of Royal Dutch/Shell (since 2021, Shell) considering the campaign against them and their operations in Nigeria in the mid-1990s. Using the concept counter-frames we analyse Shell's internal documentation of the campaign to understand how a multinational extractive industry engaged in disputes of legitimacy and against critiques of their operations. Focusing o
Crises are a major driving force behind cooperation in the European Union. During severe crises, cooperation has been enlarged and intensified. The Ukrainian war and the covid-19 pandemic are two examples of this pattern, not least when it comes to the conduct of stabilization policies in the EU. In this chapter, we discuss the implications for the EU of a move towards increased fiscal federalism.
Brain tumours are among the most common cancer diagnoses in paediatrics. Children with brain tumours are at risk of developing sleep problems because of direct and indirect effects of the tumour and its treatment, in addition to psychosocial and environmental factors. Sleep has an important role in physical and psychological wellbeing, and sleep problems are associated with many adverse outcomes.
Herpes simplex virus type 1 (HSV-1) delivers its genome into the host nucleus via docking of the viral capsid at the nuclear pore complex (NPC), a process mediated by the capsid vertex-specific complex (CVSC), composed of UL17, UL25, and UL36. While prior in vivo studies have implicated UL25 and UL36 in NPC interactions, their interpretation is complicated by indirect effects from viral traffickin
Background: Drug-related problems are common in older individuals. A medication reconciliation has the goal of identifying and maintaining an accurate medication list and can serve to prevent drug-related problems caused by discrepancies. Objectives: This study aimed to explore primary care physicians’ intentions towards performing medication reconciliation in patients with multimorbidity using a
Background Recent decades have witnessed tangible improvements in childhood cancer survival. However, the prognosis for children with congenital heart disease (CHD), the most prevalent birth defect, remains unclear. Due to improved survival of CHD and childhood cancer, evaluating outcomes within this intersection is important for clinical practice. We aimed to assess mortality post-cancer diagnosi
Evolutionary prediction and control are increasingly interesting research topics that are expanding to new areas of application. Unravelling and anticipating successful adaptations to different selection pressures becomes crucial when steering rapidly evolving cancer or microbial populations towards a chosen target. Here we introduce and apply a rich theoretical framework of optimal control to und
OBJECTIVE: Twin studies have demonstrated that posttraumatic stress disorder (PTSD) is moderately heritable, and the pattern of findings across studies suggests higher heritability in females compared with males. Formal testing of sex differences has yet to be done in twin studies of PTSD. The authors sought to estimate the genetic and environmental contributions to PTSD, and to formally test for
ADP-ribosyltransferase ARTD1/PARP1 is a target for cancer and ischemia drug development. Several other ARTD-family enzymes have been characterized in recent years, and it has become clear that their inhibition might also have therapeutic value. This minireview series summarizes current knowledge of pharmacological inhibition of ADP-ribosyltransferases by a compound class called PARP inhibitors and
