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Syftet med vår studie är att undersöka de problem som kan uppstå vid en överföring av ett styrinstrument, innehållande Key Performance Indicators, från en organisation till en annan i samband med förvärv. Uppsatsen utgår från en fallstudie av ett företag i kemibranschen. I vår fallstudie använder vi ett abduktivt angreppssätt och en kvalitativ metod. I den teoretiska referensramen utgår vi ifrån t
A 2-month psychological questionnaire concerning pregnancy was answered by 20,920 nondiabetic mothers of singletons. Retrospective analysis showed increased levels of islet autoantibodies (1A) in 290 (1.4%) newborns. High IA levels in the child's cord blood correlated strongly with IA levels in the mother (GADA r = 0.91, P < 0.0001; IA-2A r = 0.75, P = 0.0001). High IA levels were found in newborn
New basis sets of the atomic natural orbital (ANO) type have been developed for the first, second, and third row transition metal atoms. The ANOs have been obtained from the average density matrix of the ground and lowest excited states of the atom, the positive and negative ions, and the atom in an electric field. Scalar relativistic effects are included through the use of a Douglas-Kroll-Hess Ha
The identification of genes underlying quantitative-trait loci (QTL) for complex diseases, such as rheumatoid arthritis, is a challenging and difficult task for the human genome project. Through positional cloning of the Pia4 QTL in rats, we found that a naturally occurring polymorphism of Ncf1 (encoding neutrophil cytosolic factor 1, a component of the NADPH oxidase complex) regulates arthritis s
Proton acceleration from the interaction of ultra-short laser pulses with thin foil targets at intensities greater than 10(18) W cm(-2) is discussed. An overview of the physical processes giving rise to the generation of protons with multi-MeV energies, in well defined beams with excellent spatial quality, is presented. Specifically, the discussion centres on the influence of laser pulse contrast
Long term follow up of 16 homosexual men and 78 intravenous drug abusers who were chronic carriers of hepatitis B surface antigen (HBsAg) showed fundamental differences between the two groups. Viral replication, expressed by the presence of hepatitis B e antigen, lasted for four years or more in 10 out of 14 (71%) of the homosexual men whereas it was not present in 43 out of 73 (59%) of the drug a
ABSTRACT: BACKGROUND: In Guinea-Bissau HIV-1, HIV-2, and HTLV-I are prevalent in the general population. The natural history of HIV/HTLV-I single and dual infections has not been fully elucidated in this population. Previous studies have shown that combinations of these infections are more common in older women than in men. The present study compares mortality associated with HIV-1, HIV-2, and HTL
The results of a theoretical study of the ground state, 1(1)A(g), and of the lowest B-1(u) states of trans-stilbene are presented. The vertical and adiabatic excitation energies of the lowest B-1(u) states have been computed using multiconfigurational SCF theory, followed by second-order perturbation. theory. It is shown that the two lowest excited states are separated by a small energy gap in the
Rheumatoid arthritis is a chronic inflammatory disease associated with certain HLA-DR4 subtypes. The target autoantigen(s) is unknown, but type II collagen (CII) is a candidate, with a single immunodominant DR4-restricted 261-273 T cell epitope (CII(261273)). In the present study, we have prepared HLA-DR4:CII(261-273) tetramers and analyzed peripheral blood, lymph node, and synovial fluid cells fr
The immunodominant T-cell epitope that is involved in collagen-induced arthritis (CIA) is the glycosylated type II collagen (CII) peptide 256-270. In CII transgenic mice, which express the immunodominant CII 256-270 epitope in cartilage, the CII-specific T cells are characterized by a partially tolerant state with low proliferative activity in vitro, but with maintained effector functions, such as
A role for regulatory lymphocytes has been demonstrated in the pathogenesis of type I diabetes in the NOD mouse but the nature of these cells is debated. CD1d-restricted NKT lymphocytes have been implicated in this process. Previous reports of reduced diabetes incidence in NOD mice in which the numbers of NKT cells are artificially increased have been attributed to the enhanced production of IL-4
This thesis is focused on natural killer (NK) T cells. NKT cells recognize lipids and glycolipids, rather than peptides, in the contents of the antigen presenting molecule CD1d. NKT cells have a surface phenotype reminiscent of memory cells, and have been shown to rapidly produce large amounts of cytokines, such as IL-4 and IFN-gamma, upon activation. Because of their rapid response to activation,
Oklarhetsregeln är en avtalsrättslig princip som härstammar från den romerska rätten och återfinns i flera rättsordningar och internationella principsamlingar. I Corpus Juris Civilis är den latinska formuleringen av regeln ambiguitas contra stipulatorem est och på engelska omnämns den som the contra proferentem rule. Även om oklarhetsregeln är en välkänd princip, är den kontroversiell. HD har exemThe contra proferentem rule is a legal doctrine in contract law, which originates from the Roman law. Today, the rule is known in several legal systems and is used in international collections of principles. In Corpus Juris Civilis the Latin wording of the rule is ambiguitas contra stipulatorem est and in Sweden the rule is known as oklarhetsregeln. Even though the rule is well known, it is contro
Under år 2015 antog regeringen en ändring av brottsbalken (BrB, 1962:700) som ger rätten en möjlighet att erkänna strafflindring i fall där den tilltalade medverkar till utredningen av sin egen brottslighet (29 kap. 5 a § 1 st. BrB). Fastän ändringen hade önskvärda syften, bland annat en ökad effektivitet, är rätten att inte belasta sig själv en generell och grundläggande rättighet som inte får glIn 2015, the Swedish government adopted an amendment of the Swedish Criminal Code (brottsbalken, 1962:700) which grants the court a possibility to reduce the penalty in cases where the defendant contributes to the investigation of their own crime (chapter 29 § 5 a 1). While the rationale behind the amendment lies upon desirable arguments such as efficiency, the privilege against self-incrimination
Humanitära interventioner är ett väl debatterat ämne inom internationell rätt. Det är ett ämne som väcker stora känslor och diskussioner bland jurister samt inom och emellan stater världen över. När det gäller legaliteten av humanitära interventioner finns det mycket material att tillgå, dock övergår diskussionen sällan i det som egentligen är viktigast: Borde humanitära interventioner vara lagligHumanitarian interventions is a well debated subject within international law. When it comes to the legality of humanitarian interventions the international community is divided and a lot of material regarding such interventions can be found. Unfortunately, the discussion rarely turns to the more important question: Should humanitarian interventions be legal under contemporary international law? T
Föräldraalienation är ett fenomen som innebär att en förälder påverkar det gemensamma barnet att ta avstånd från den andra föräldern utan grund, trots att föräldern varit god och omsorgsfull. Det uppstår oftast i svåra vårdnadstvister. Vidare kan detta anses inbegripet i umgängessabotage, exempelvis om en förälder påverkar barnet att inte vilja umgås med den andra föräldern. Barnet tillskrivs månParental alienation is a social phenomenon where a parent influences its Child to dissociate itself from the other parent without justification, even though the parent has been careful and gentle. The phenomenon usually arises in high conflict custody disputes. Furthermore, parental alienation might be considered access sabotage, for example if the parent influences the child to reject access to t
The effect of prostate-specific antigen (PSA) screening on prostate cancer mortality remains debated, despite evidence from randomized trials. We investigated the association between prostate cancer incidence, reflecting uptake of PSA testing, and prostate cancer mortality.
Whereas patients with multiple myeloma (MM) have a well-documented susceptibility to infections, this has been less studied in other B-cell disorders, such as Waldenstrom's macroglobulinemia (WM) and monoclonal gammopathy of undetermined significance (MGUS). We investigated the humoral immunity to 24 different pathogens in elderly patients with MM (n = 25), WM (n = 16), and MGUS (n = 18) and in ag
An NMR technique to measure exchange kinetics at thermal equilibrium in dispersions of moderately soluble crystalline material is presented. By monitoring the exchange of molecules between pools in solid and dissolved form, one can characterize the surface specific exchange rate. Illustrative experiments were performed in a model system with b-type crystals of tripalmitin as the solid phase and tr
Gastric bypass is a clinical option for obesity surgery. An increased susceptibility to Helicobacter pylori infection in the bypassed stomach has been speculated. The aim of the present study was to examine the susceptibility of the bypassed stomach to H. pylori infection in rats and mice. Adult Sprague-Dawley and Wistar rats and NMRI mice were subjected to either gastric bypass or laparotomy only
