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P>Toll-like receptors (TLRs) are increasingly implicated in the pathogenesis of cancer. The present study describes TLR expression and function in healthy and malignant airway epithelial cells. The squamous cell carcinoma cell line Detroit-562 was compared with the healthy bronchial epithelial cell line NL-20 and primary human nasal epithelial cells (HNECs). TLR2, TLR3 and TLR5 were present in pri

High-resolution transmission spectroscopy has become a powerful tool for detecting atomic and ionic species in the atmospheres of ultra-hot Jupiters. In this study, we demonstrate for the first time that the Australian-built Veloce spectrograph on the 3.9-m Anglo-Australian Telescope can resolve atmospheric signatures from transiting exoplanets. We observed a single transit of the ultra-hot Jupite

Enumeration of circulating tumor cells (CTCs) obtained from minimally invasive blood samples has been well established as a valuable monitoring tool in metastatic and early breast cancer, as well as in several other cancer types. The gold standard technology for detecting CTCs in blood against a backdrop of millions of leukocytes is the FDA-approved CellSearch system (Janssen Diagnostics), which r

Optimization of islet transplantation protocols is necessary for improved success of treatment for type 1 diabetes. Here, we investigated whether the size of islets transplanted into the portal vein (PV) of the liver can affect engraftment in the early post-transplantation in an experimental mouse model. Small (average diameter < 250 mu m, group A) or large (average diameter > 250 mu m, group B) i

Popular Abstract in Swedish Under de senaste åren har förtidspensionen och dess funktionssätt hamnat i fokus för den politiska debatten. Behovet av en förnyad, anpassad och mer ekonomiskt hållbar försäkring har framförts i politiska diskussioner, offentliga utredningar och inom forskarsamhället sedan början av 1990-talet. Samtidigt har kritik riktats mot att det finns skillnader och glidningar i fThe Swedish disability pension program has been a recurring topic for political debate. Through the years the need for an adjusted and financially stable insurance has been commented on by politicians and by scholars. Numerous government reports have tackled both the costs of the program and the growing number of people granted disability pensions. During the last ten years the disability pension

This study explores the nexus between financial inclusion and agricultural productivity in Tanzania, where agriculture is a key sector for the nation's economy and inclusive growth. Vulnerable to climate change, the sector faces productivity challenges due to rain anomalies and rising temperatures. Previous studies have highlighted financial inclusion as crucial for reducing vulnerability at t

The seventeen sustainable development goals are the response of the United Nations to make efforts for economic growth, social development, and environmental conservation. International organizations, governments, and the private sector play a fundamental role to achieve the 2030 Agenda of sustainable development. The demand for financial sources brings attention to foreign investment as a source

The concept of actor capability outlines the basic features for the EU to be an international actor, separating it from nation-states and international organizations. This thesis applies this diagnostic concept to the case of EU-relations with the Democratic People’s Republic of Korea (DPRK). More specifically, it studies how the actor capability has changed by comparing the years 2001 and 2011 re

The study investigates how the consumption of bulk commodities has transformed from mundane to remarkable and reveals how people, events, meanings and ideas from the past have affected this change in consumers’ attitude. The paper discusses how mundane products have become a center of consumer interest and provides theoretical explanation of the phenomenon. The research focuses on bottled water as

The aim of this thesis is to investigate if the Lutheran heritage, represented by a comparison between early Lutheran writings and Luther’s source of inspiration Theologia Germanica, can provide a starting point for potentially unifying dialogues within Christian circles. The background of this pursuit of unity is the ecumenical problem of the seemingly opposite views of how faith and deeds relate

Rationale: Patients with obesity hypoventilation syndrome (OHS) have high risk of hospitalization, which might be decreased by home mechanical ventilation (HMV). Objectives: To evaluate annualized hospitalization rate (AHR) and changes in AHR in patients with OHS starting HMV and explore if there were any differences in AHR by starting HMV acutely or electively. Methods: This was a population-base

BACKGROUND: Several studies have examined the effect of community interventions on youth alcohol consumption, and the results have often been mixed. The aim of this study is to evaluate the effectiveness of a community intervention known as the Öckerö Method on adolescent alcohol consumption and perceived parental attitudes towards adolescent drinking. METHOD: The study is based on a quasi-experim

Activation of AMP-activated protein kinase (AMPK) is considered a valid strategy for the treatment of type 2 diabetes. However, despite the importance of adipose tissue for whole-body energy homeostasis, the effect of AMPK activation in adipocytes has only been studied to a limited extent and mainly with the AMP-mimetic 5-aminoimidazole-4-carboxamide-1-b-d-ribofuranoside (AICAR), which has limited

ObjectivesTo identify cytokines that can activate and expand NK cells in the presence of prostate cancer cells in order to determine whether these agents may be useful in future intra‐tumoural administration in pre‐clinical and clinical prostate cancer trials.Materials and MethodsLymphocytes isolated from normal donor blood were set up in co‐cultures with either cancer or non‐cancerous prostate ce

BACKGROUND: Recent research using a data-driven cluster approach has identified five discordant subclassifying body mass index (BMI) subgroups, characterized by cardiometabolic biomarkers deviated from those predicted by BMI.OBJECTIVE: This study aimed to investigate the associations of these subgroups with risks of metabolic dysfunction-associated steatotic liver disease (MASLD) and liver-related

Gene therapy is emerging as a groundbreaking strategy for treating epilepsy, offering new hope to patients who do not respond to conventional medications. Despite advancements in anti-seizure treatments, nearly 30%–40% of individuals with epilepsy continue to experience uncontrolled seizures, highlighting the urgent need for more effective and long-lasting solutions. By addressing the underlying c

Second language acquisition (SLA) research has historically prioritized classroom-based contexts, with the exception of areas such as study abroad, incidental and self-directed learning. In the last decades, however, research interest in second language (L2) learning beyond the classroom has grown substantially, expanding our understanding of where and how L2 learning takes place. This can be larg