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A combination of mesoscale hydrodynamic simulations and microfluidic experiments are used to explore the use of cells' mechanical and dynamical properties as biomarkers for separation. Dynamic behaviour of red blood cells (RBCs) within deterministic lateral displacement (DLD) devices is investigated within various array geometries and for different viscosity contrasts between the intra- and extra-

Mesoscopic simulations with two-dimensional (2D) models have been performed to elucidate the dynamics of deformable red blood cells (RBCs) in deterministic lateral displacement (DLD) devices. Several shapes of posts, including circular, diamond, square and triangular structures and RBCs with different rigidities are considered. In comparison to rigid particles, the deformable RBCs exhibit much mor

IMPORTANCE: The value of microRNAs (miRNAs) as biomarkers has been investigated in various clinical contexts. Initial small-scale studies suggested that miRNAs might be useful indicators of outcome after cardiac arrest. OBJECTIVE: To address the prognostic value of circulating miRNAs in a large cohort of comatose patients with out-of-hospital cardiac arrest. DESIGN, SETTING, AND PARTICIPANTS: This

In the course of 2000s, the region of Campania in southern Italy and its capital city Naples became global icons of waste mismanagement after the images of piles of rubbish occluding their urban areas hit the headlines. Conventional explanations, in Italy and elsewhere, pointed to administrative failure, cultural backwardness and mafia infiltration as the main causes of waste mishandling. In the s

Introduction: In Sweden, head computed tomography (CT) is commonly used for prediction of neurological outcome after cardiac arrest, as recommended by guidelines. We compare the prognostic ability and interrater variability of routine and novel CT methods for prediction of poor outcome. Methods: Retrospective study including patients from Swedish sites within the Target Temperature Management afte

Significant efforts are ongoing to develop refined differentiation protocols to generate midbrain dopamine (DA) neurons from pluripotent stem cells (PSCs) for application in disease modeling, diagnostics, drug screening, and cell-based therapies for Parkinson's Disease (PD). An increased understanding of the timing and molecular mechanisms promoting the generation of distinct subtypes of human mid

We present an improved acoustophoretic system for circulating tumor cell separation from blood. The system is operated by pressure driven flow, including flow sensors and a feed-back loop for precise flow control. The pressure driven system provides a user interface that can be handled by a non-skilled operator, and most importantly full clinical samples of 7 mL can be processed in 70 minutes. The

Objectives To identify the arthritogenic B cell epitopes of glucose-6-phosphate isomerase (GPI) and their association with rheumatoid arthritis (RA). Methods IgG response towards a library of GPI peptides in patients with early RA, pre-symptomatic individuals and population controls, as well as in mice, were tested by bead-based multiplex immunoassays and ELISA. Monoclonal IgG were generated, and

Denna avhandling studerar lokala aktörers roll vid förändringsarbete i gamla industriregioner. En gammal industriregion definieras som ett område med en ensidig och överspecialiserad industristruktur, som är dominerad av mogen industri och som upplever minskad sysselsättning och/eller avindustrialisering. Denna typ av region är ofta starkt påverkad av gamla strukturer och förväntas därför ha svåraThe aim of the dissertation is to develop a better understanding of the role of local agency in the transformation of old industrial regions. Theoretically the dissertation builds on concepts which are important in the debate on regional development in old industrial regions such as path dependency, negative lock-ins, the role of institutions, and new path development, while exploring and unpackin

Background: The CREST model is a prediction model, quantitating the risk of circulatory-etiology death (CED) after cardiac arrest based on variables available at hospital admission, and intend to guide the triage of comatose patients without ST-segment-elevation myocardial infarction after successful cardiopulmonary resuscitation. This study assessed performance of the CREST model in the Target Te

CD4 tissue-resident memory T cells (TRM) are crucial adaptive immune components involved in preventing influenza A virus (IAV) infection. Despite their importance, their physiological role in the upper respiratory tract, the first site of contact with IAV, remains unclear. Here, we find that, after IAV infection, antigen-specific CD4 TRM persist in the nasal tissue (NT) compartment after infection

Accurate and continuous monitoring of inland surface‌ water dynamics is vital for sustainable water resource management, climate impact assessment, and ecological planning. This study introduces a machine learning-based remote sensing-based data-fusion framework that improves Sentinel-3 radar altimeter (SRAL) estimations of water surface elevation (WSE) by integrating ERA5 reanalysis climate varia

Purpose of Review: Many aspects of reproduction have been associated with increased blood pressure and impaired glucose metabolism that reveals a subsequent increased risk of cardiovascular disease. The aim of this review is to assess reproductive life factors associated with an increased risk of hypertension and cardiovascular disease, e.g., early life programming, sexual, and reproductive health

Parkinson's disease (PD) is a neurodegenerative disorder characterized by protein inclusions mostly composed of aggregated forms of α-synuclein (α-Syn) and by the progressive degeneration of midbrain dopaminergic neurons (mDANs), resulting in motor symptoms. While other brain regions also undergo pathologic changes in PD, the relevance of α-Syn aggregation for the preferential loss of mDANs in PD

A people-centred approach for designing large-scale built-up spaces necessitates systematic anticipation of user’s embodied visuo-locomotive experience from the viewpoint of human-environment interaction factors pertaining to aspects such as navigation, wayfinding, usability. In this context, we develop a behaviour-based visuo-locomotive complexity model that functions as a key correlate of cognit

Background Pancreatic ductal adenocarcinoma (PDAC) represents a major clinical challenge due to its tumor microenvironment, which exhibits immune-suppressive properties that facilitate cancer progression, metastasis, and therapy resistance. Interleukin 1 (IL-1) signaling has been implicated as a driver in this process. Mechanistically, both IL-1α and IL-1β bind to the IL-1 receptor type 1, forming

Neurotensin (NT) is a gut hormone functioning proinflammatory through nuclear factor kappa B (NF-κB) and interleukin (IL)−8 secretion or anti-inflammatory through epidermal growth factor receptors. NT mRNA is down-regulated in duodenal biopsies of children with untreated coeliac disease. The aim of this study was to investigate if plasma pro-NT levels correlated with the degree of intestinal mucos