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Current immune-based therapies signify a major advancement in cancer therapy; yet, they are not effective in the majority of patients. Physically based local destruction techniques have been shown to induce immunologic effects and are increasingly used in order to improve the outcome of immunotherapies. The various local destruction methods have different modes of action and there is considerable
This book analyses and discusses the use of Islamic terms and symbols in the political party Sri Lanka Muslim Congress (SLMC). It is based on interviews with the leading members of the party and on analyses of the party’s official documents. It describes the history of Muslims in Sri Lanka, presents the analytical framework used, and discusses the official documents and narratives of party members
Cytoreduction followed by hyperthermic intraperitoneal chemotherapy is a treatment option for peritoneal surface malignancies in The Netherlands. This treatment has been available for more than 10 years. Therefore, long-term results on survival and quality of life can now be studied. With these results, the true long-term benefits of this new management strategy can be determined.
This chapter critically engages with a central policy norm developed by key international actors working on statelessness and refugeeness over the last three decades. This is the norm that for stateless refugees their refugeeness effectively trumps their statelessness. I term this norm, which arbitrarily separates and ranks statelessness and refugeeness, the “protection hierarchy”. This norm is in
In this research–in–progress paper, we employ design science research to articulate design knowledge for chatbots in higher education practice. We conducted a literature review to factor previous research into the design process. In addition, we performed a content analysis of student e-mails and forum posts from four instances of a basic Java programming course. Drawing from literature and data,
Motivated by the need for realistic, dynamically self-consistent, evolving galaxy models that avoid the complexity of full, and zoom-in, cosmological simulations, we have developed Nexus, an integral framework to create and evolve synthetic galaxies made of collisionless and gaseous components. Nexus leverages the power of publicly available, tried-and-tested packages: the stellar-dynamics, action
Chromosomal aneuploidy, that is, numerical chromosome aberrations, is one of the molecular hallmarks of cancer. However, when neoplasms are studied with sequencing- and array-based approaches, chromosome numbers and ploidy states are typically inferred from bulk DNA data. Furthermore, published molecular estimates of neoplasia-associated aneuploidy often also include genomic imbalances resulting f
Context: In a cross-sectional study, we found an association between type 2 diabetes mellitus (T2DM) and smaller bone area together with greater bone mineral density (BMD) at the total hip.Objective: This work aims to investigate these associations longitudinally, by studying T2DM status (no T2DM n = 1521, incident T2DM n = 119, or prevalent T2DM n = 106) in relation to changes in total hip bone a
ABSTRACTObjectivesAn emerging body of research reveals a heightened risk of gambling problems among elite athletes, particularly among males, but these studies often suffer from small sample sizes and lack diverse representation across sports and groups. This study aimed to investigate gambling problems and their correlates among elite male and female ice hockey players in Sweden’s top leagues.Met
We introduce a new method to calculate dark matter halo density profiles from simulations. Each particle is ‘smeared’ over its orbit to obtain a dynamical profile that is averaged over a dynamical time, in contrast to the traditional approach of binning particles based on their instantaneous positions. The dynamical and binned profiles are in good agreement, with the dynamical approach showing a s
In nine hyperthyroid women studied in the follicular phase of the menstrual cycle basal plasma LH concentrations and LH and FSH responses to GnRH were increased compared to those in nine normal women. The increased gonadotropin levels could not be related to changes in body weight or plasma estradiol or serum sex hormone-binding globulin levels, and they approached normal levels during or after tr
Cancer cells evade the immune system by downregulating antigen presentation. Although immune checkpoint inhibitors (ICI) and adoptive T-cell therapies revolutionized cancer treatment, their efficacy relies on the intrinsic immunogenicity of tumor cells and antigen presentation by dendritic cells. Here, we describe a protocol to directly reprogram murine and human cancer cells into tumor-antigen-pr
Swedish institutions of higher education must promote widening participation. This goal is also expressed in policy documents at Lund University. To accomplish this, teachers at Lund University formed a group to strategically work towards student inclusion. This article reports on an interview study conducted by this group investigating students’ experiences and perceptions of entering education a
Chromosome abnormalities, in particular translocations, and gene fusions are hallmarks of neoplasia. Although both have been recognized as important drivers of cancer for decades, our knowledge of the characterizing features of the cytobands involved in recombinations is poorly understood. The present study, based on a comparative analysis of 10 442 translocation breakpoints and 30 762 gene fusion
Myxoid liposarcoma (MLS) is molecularly characterized by fusions involving the DDIT3 gene in chromosome band 12q13; the fusion partner is FUS in band 16p11 in 90–95% of the cases and EWSR1 in band 22q12 in the remaining 5–10%. Hence, molecular studies, often fluorescence in situ hybridization (FISH) for DDIT3 rearrangement, are useful for establishing a correct diagnosis. Although all MLS tumors s
This chapter examines the institutional dimensions of religious responsesto forced migration in contemporary Georgia. It focuses on the internallydisplaced population of Georgia from the two breakaway territories ofAbkhazia and South Ossetia/Tskhinvali region to further scrutinise howmajor religious organisations respond to the signifijicant migration crises onthe level of policy and discourse. The
