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BACKGROUND: Inflammation and immune responses are considered to be very important in the pathogenesis of atherosclerosis. Lipid accumulation in macrophages of the arterial intima is a characteristic feature of atherosclerosis which can influence the inflammatory potential of macrophages. We studied the effects of lipid loading on the regulation of TNF expression in human monocyte-derived macrophag
Gm allotypes are genetic variants of the immunoglobulin heavy G chains (IGHG) of IgG molecules, coded from chromosome 14q32, characterized by differences in amino acid epitopes of the constant heavy G chains and inherited in the Mendelian manner. Gm allotypes have influence on IgG subclass levels, and serum Gm allotype levels have been given for different Gm genotypes in adults. Four hundred and t
Rheumatoid arthritis (RA) is an autoimmune disease characterized by a persistent inflammation of the synovium, leading to the erosion of articular cartilage and bone. Synovial mast cells and their effector molecule, histamine, receive increased attention as mediators of joint inflammation. The aim of our study was to analyse levels of free histamine in serum and joint fluid of RA patients and to e
Relapsing polychondritis is an autoimmune disease in which an inappropriate immune response destroys cartilage. Cartilage of the ears, larynx and nose rather than spine and joint cartilage is affected by a chronic relapsing and erosive inflammation. Several animal models for relapsing polychondritis have been published in which immunization with various cartilage proteins induces a variety of chon
We investigate how a small polar molecule, urea, can act to protect a phospholipid bilayer system against osmotic stress. Osmotic stress can be caused by a dry environment, by freezing, or by exposure to aqueous systems with high osmotic pressure due to solutes like in saline water. A large number of organisms regularly experience osmotic stress, and it is a common response to produce small polar
Title: The important role of the consultant Problematization: In today’s competitive markets it is important to maintain a competitive advantage. One opportunity to do this is by implementing an ERP system to the organization. Many organisations have implemented an ERP system, but a lot have been unsuccessful. Studies have been done to identify the main success factors connected with the impleme
One third of all food that is globally produced is wasted every year. This essay develops a duty approach to the growing global food waste. Is there a duty not to waste food? The theoretical perspective of this essay is based on the correlative between rights and duties and on Thomas W. Pogge’s theories of global institutional duties. The thesis is that there is a global duty not to contribute to
If two undertakings agree to increase their prices, companies may infringe Article 101 of the TFEU which prohibits anti-competitive agreements and concerted practices. If the market is divided between two or more undertakings, the agreement may constitute abuse of collective dominance under Article 102 TFEU. The undertakings might be able to adjust their behaviour so that they could behave as they
The paper investigates the mean and volatility spillover effects from U.S and EU stock markets as well as oil price market into national stock markets of eight European countries. The study finds strong indication of volatility spillover effects from global US, regional EU, and world factor oil towards individual stock markets. While both mean and volatility spillover transmissions from the U.S ar
The mean and volatility spillover effects from the US and the aggregate European stock markets into individual Scandinavian equity markets are investigated by applying an EGARCH volatility-spillover model. Both the mean and volatility spillover effects from the US market are found to be significant. The European mean-spillover effects are small, negligible, and insignificant whereas the EU volatil
This report is a fire safety evaluation of Västralid nursing home in Olofström. The object consist of three connected housing bodies, first built in the 1970’s. At first, the buildings were used as regular apartments, but they were converted into nursing apartments for elderly people in the 1990’s. In the report, an analysis of fire scenarios are compared to egress scenarios to evaluate the perso
The media’s portrayal of the witness during court proceedings is putting the witness at risk for threats. This has led to the witness not wanting to testify, especially as the case concerns organized crime. It is an age old debate where intimidated witnesses are a concern for the legal system, and people’s human rights in general. The debate is complex as the use of anonymous witnesses goes agains
Att marknadsandelarna är av betydelse för dominansbedömningen är välkänt inom konkurrensrätten. Frågorna är snarare vilken och hur stor betydelse marknadsandelarna har för bedömningen och utgången i ett specifikt fall i förhållande till övriga faktorer. Frågan uppmärksammades redan i United Brands varför också domen har kommit att verka som prejudicerande rättspraxis för flertalet senarkommande do
A computational model with three interacting components for context sensitive re-inforcement learning, context processing and automation can autonomously learn a focus attention and a shift attention task. The performance of the model is similar to that of normal children, and when a single parameter is changed, the performance on the two tasks approaches that of autistic children.
The text is an introduction to a collection of articles from the research project The Holocaust and European Historical Culture.
Purpose – The purpose of this paper is to systematically and critically review the extant literature on the design of global production and distribution networks to identify gaps in the literature and identify future research opportunities. The design aspects deal with strategic and structural decisions such as: opening or closing of manufacturing plants or distribution centres, selection of locat
