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BACKGROUND: The melanoma-specific survival (MSS) is heterogenous between stages and is highly dependent on the T stage for primary localized disease. New systemic therapies for metastatic cutaneous melanoma (CM) have been introduced since 2012 in Sweden.OBJECTIVES: To analyse the incidence and MSS time trends between 1990 and 2020 in Sweden.METHODS: Nationwide, population-based, and prospectively
The transport sector accounts for approximately 20% of EU-27 greenhouse gas (GHG) emissions, and 27% of U.S. GHG emissions. With the Kyoto Protocol, Sweden and several other nations have agreed to reduce these emissions. Often, solutions that involve consolidating freight and moving it to more carbon-efficient transport technologies are advocated as the most advantageous. For such initiatives the
Background: Early prediction of childhood type 1 diabetes reduces ketoacidosis at diagnosis and provides opportunities for disease prevention. However, only highly efficient approaches are likely to succeed in public health settings. We sought to identify efficient strategies for initial islet autoantibody screening in children younger than 15 years. Methods: We harmonised data from five prospecti
This chapter provides conceptual and empirical foundations for smart specialization, a policy approach of far-reaching importance in the European context. We interpret the very notion as “diversified” specialization into areas of existing or potential competitive advantage, which differentiates a region/nation from others. “Smart” relates to the identification of these areas through a process of e
Over the past decades, it has become more and more obvious that ongoing globalisation processes have substantial impacts on the natural environment. Studies reveal that intensified global economic relations have caused or accelerated dramatic changes in the Earth system, defined as the sum of our planet’s interacting physical, chemical, biological and human processes (Schellnhuber et al. 2004). Cl
Chromosome abnormalities, in particular translocations, and gene fusions are hallmarks of neoplasia. Although both have been recognized as important drivers of cancer for decades, our knowledge of the characterizing features of the cytobands involved in recombinations is poorly understood. The present study, based on a comparative analysis of 10 442 translocation breakpoints and 30 762 gene fusion
Myxoid liposarcoma (MLS) is molecularly characterized by fusions involving the DDIT3 gene in chromosome band 12q13; the fusion partner is FUS in band 16p11 in 90–95% of the cases and EWSR1 in band 22q12 in the remaining 5–10%. Hence, molecular studies, often fluorescence in situ hybridization (FISH) for DDIT3 rearrangement, are useful for establishing a correct diagnosis. Although all MLS tumors s
Pulmonary fibrosis is a severe condition in interstitial lung diseases (ILD) such as idiopathic pulmonary fibrosis (IPF) and systemic sclerosis-ILD, where the underlying mechanism is not well defined and with no curative treatments available. Serotonin (5-HT) signaling via the 5-HT 2B receptor has been recognized as a promising preclinical target for fibrosis. Despite this, the involvement of the
Forty-two chapters have been structured according to the toxicities in cancer entities, and the late effects and follow-up proposals have been discussed by European and American authors. Cancer diseases in children, adolescents and young adults are treated within specific treatment protocols and can produce different late effects that will have to be cared for by specific follow-up recommendations
The purpose of the presented garbage collector interface is to provide a universal interface for many different implementations of garbage collectors. This is to simplify the integration and exchange of garbage collectors, but also to support incremental, non-conservative, and thread safe implementations. Due to the complexity of the interface, it is aimed at code generators and preprocessors. Exp
This thesis, which is based on four original papers, covers different aspects of antibody development. The overall goal of my work has been to obtain an increased understanding of antibody repertoires as they develop in vivo and in vitro. In Paper I-III antibody repertoires was evaluated and used to dissect virus-induced antibody responses and characterize such antibodies. Furthermore, tools for m
Cancer cells evade the immune system by downregulating antigen presentation. Although immune checkpoint inhibitors (ICI) and adoptive T-cell therapies revolutionized cancer treatment, their efficacy relies on the intrinsic immunogenicity of tumor cells and antigen presentation by dendritic cells. Here, we describe a protocol to directly reprogram murine and human cancer cells into tumor-antigen-pr
Swedish institutions of higher education must promote widening participation. This goal is also expressed in policy documents at Lund University. To accomplish this, teachers at Lund University formed a group to strategically work towards student inclusion. This article reports on an interview study conducted by this group investigating students’ experiences and perceptions of entering education a
We introduce a new method to calculate dark matter halo density profiles from simulations. Each particle is ‘smeared’ over its orbit to obtain a dynamical profile that is averaged over a dynamical time, in contrast to the traditional approach of binning particles based on their instantaneous positions. The dynamical and binned profiles are in good agreement, with the dynamical approach showing a s
Denna artikel utforskar hur ledande beslutsfattare navigerar förhållandet mellan mänskligt omdöme och dataanalys i sina beslutsprocesser. Genom kvalitativa metoder, inklusive intervjuer med beslutsfattare från olika organisationer, avslöjar studien balansen mellan mänsklig intuition och datadrivna beslut. Resultaten belyser den fortsatta betydelsen av mänskligt omdöme bredvid teknologiska framsteg
The thesis covers human rights violations against persons with disabilities, focusing on their right to political life and the right to vote, using the framework of critical disability theory. The aim of the thesis is two-folded: it analyses the use of the UN Convention on the Rights of Persons with Disabilities (CRPD) in the adjudication of the European Court of Human Rights (ECtHR) with a focus
