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Summary Proteinase 3 (PR3) is a major autoantigen in anti-neutrophil cytoplasmic antibodies (ANCA)-associated systemic vasculitis (AASV), and the proportion of neutrophils expressing PR3 on their membrane (mPR3(+)) is increased in AASV. We have shown recently that mPR3 and CD177 are expressed on the same cells in healthy individuals. In this study we try to elucidate mechanisms behind the increase

Aims: Gestational diabetes mellitus affects approximately 7% of all pregnant women. Some of these women develop autoantibodies that are generally characteristic of Type 1 diabetes. Autoantibodies targeting glutamic acid decarboxylase and tyrosine phosphatase-like protein are the most frequently reported. A recently identified autoantigen in Type 1 diabetes is zinc transporter 8. Some reports sugg

Since the Rio+20 gathering in 2012, and under the banner of blue growth, heads of state, corporations, investors and environmental NGOs have been debating the oceans’ role in solving everything from world food security, to provisioning of energy and natural resources, to mitigating the impacts of climate change and ensuring improved medical care. For the ocean and its resources to play this role,

It is often said that we live in a consumer society. This does not just mean that we buy things regularly but also that consumption is an integral part of our daily lives. We have learned to think of ourselves as consumers, rather than citizens, in a variety of situations. Against this backdrop, retail organisations hold a strategically important position, not least because of the space they occup

In this paper we describe a small pilot study designed to explore the possibility of spatial pseudo haptic effects induced by artificial audio feedback. Four basic audio designs were investigated: pan, continuous since tone, virtual harp and noise. For reference a visual pseudo haptic effect together with real haptic effects were also included. The results indicate noise and spatially distributed

Popular Abstract in Swedish Den här avhandlingen handlar om hur moln påverkas av luftburna partiklar, så kallade aerosolpartiklar. Moln bildas i atmosfären när vatten övergår från gasfas till vätskefas, det vill säga när vattenånga kondenserar. För att molndroppar ska kunna bildas krävs dock aerosolpartiklar, som vattenångan kan kondensera på. Antalet partiklar i luften kan därigenom påverka hur mCloud droplets never form in the atmosphere without a seed in the form of an aerosol particle. Changes in number concentrations of aerosol particles in the atmosphere can therefore affect the number of droplets in a cloud. Higher concentrations of aerosol particles in the atmosphere lead to clouds with more droplets and if the amount of liquid water in the clouds stay the same, the droplets become

Post-compression of ultra-short laser pulses via self-phase modulation is routinely employed for the generation of laser pulses with optical bandwidths reaching far beyond the laser gain limitations. Although high compression factors can be routinely achieved, the compressed pulses typically suffer from temporal quality degradation. We numerically and experimentally analyze the deterioration of di

Peripheral blood lymphocytes from healthy, HIV sero-negative blood donors have been in vitro immunized using penv9, a recombinant fragment of the envelope of HIV-1. This primary in vitro immunization followed by Epstein-Barr virus (EBV) transformation and somatic cell fusion subsequently gave rise to several specific anti-penv9 monoclonal antibodies (MO28, MO30 and MO43) of μ isotype. The hybridom

We present the confirmation and characterization of three hot Jupiters, TOI-1181b, TOI-1516b, and TOI-2046b, discovered by the TESS space mission. The reported hot Jupiters have orbital periods between 1.4 and 2.05 d. The masses of the three planets are 1.18 ± 0.14 MJ, 3.16 ± 0.12 MJ, and 2.30 ± 0.28 MJ, for TOI-1181b, TOI-1516b, and TOI-2046b, respectively. The stellar host of TOI-1181b is a F9IV

Anonymisation of assessments has been discussed for decades. It stems from a concern about unduly bias in assessment and grading. In Sweden, anonymised assessments were introduced in many universities a decade ago. It was rarely preceded by discussions on potential pedagogical consequences. Recent research on the effects of anonymisation does not confirm the hypothesis of reduced bias in grading.

BACKGROUND: Early glottic cancer can be treated with laser resection or radiotherapy. In an earlier study, we found that voice function after laser resection was inferior to that after radiotherapy.OBJECTIVES: This study was designed to determine if reduced margins at laser resection improved voice function without impairing oncologic results.METHOD: A total of 268 patients with previously untreat

Based on the results of an on-going monitoring program of 1612 MHz OH masers in OH/IR stars, we determined a lifetime encompassing late AGB and early post-AGB evolution of at least 4500 years. Fading of the OH masers observed with the Nançay Radio Telescope is detected in several post-AGB OH/IR stars on timescales of decades, while AllWISE/NEOWISE light curves taken almost in parallel show diverse

This project consists of a thorough study of an energy efficient and moisture safe row-house, located in the Nordic climate of Sweden. Climate and site analysis, building scale design decisions and finally the evaluation and optimization of its energy performance were different steps of a holistic process aiming at the architectural quality, energy efficiency, comfort and the well-being of users.

PURPOSE: The purpose of this research project is to further advance theory on management of product development by providing insights on customer orientations. The study contributes to the literature by bringing in Actor-Network Theory (ANT) as a new perspective to theorize the process of translations between customer orientation and engineering orientation within product development. RELEVANCE:

Purpose: Consumers are forming deep love relationships with brands to a degree that involves the incorporation of the brand’s symbolic attributes to their own self-concept. However, though deep, these bonds are not indestructible. With that said, this thesis aims to investigate the consumer-brand love relationship with specific regard to the dissolution of these deep bonds. Methodology: In-depth s

Mexico, the second largest economy in Latin America, has almost eradicated extreme poverty according to the Millennium Development Goals; however, official statistics show that by national standards poverty levels are still quite high, reaching up to half its population. This paper looks into how the determinants of poverty in Mexico have evolved after the last major economic crisis the country ex