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Introduction of exogenous genetic material into primary stem cells is essential for studying biological function and for clinical applications. Traditional delivery methods for nucleic acids, such as electroporation, have advanced the field, but have negative effects on stem cell function and viability. We introduce nanostraw-assisted transfection as an alternative method for RNA delivery to human
The accurate surface reconstruction of 3D liquid structures is an important aspect for the understanding ofspray formation and liquid breakups. In this article, an approach to image in 3D the surface of liquid structuresin sprays (such as ligaments, liquid sheets/cores and liquid blobs) is presented. The technique is named FringeProjection - Laser Induced Fluorescence (FP-LIF) which is used by ill
Background: Coeliac disease is an immune-mediated intestinal disease characterised by lifelong intolerance to dietary gluten in genetically predisposed individuals. Microbial factors including infections or bacterial microbiota have long been suspected to be involved in the aetiology, but the scientific literature on the topic is scattered and heterogeneous. Aims: To review human observational stu
On May 14, 1931, Swedish military forces opened fire and killed four striking pulp factory workers and one bystander during a demonstration in the municipality of Lunde, in the Ådalen district outside of Kramfors in northern Sweden. The killings sent shock waves through the Swedish labor movement and significantly contributed to the Social democratic win in the general elections the next year.
CONTEXT: Mild autonomous cortisol secretion (MACS) is associated with increased mortality in patients with adrenal incidentalomas (AI), but little is known regarding the potential risk associated with non-functional adrenal adenomas (NFAA), which constitute the majority of AI.OBJECTIVE: Compare mortality risk in patients with NFAA, and different levels of MACS, to matched controls.METHOD: This was
Background and ObjectivesPalau is facing a rapidly aging population and developing a comprehensive national aging policy to address the growing needs of older adults, but more research is needed to understand their circumstances and needs in relation to healthy aging. This study aims to investigate these factors and contribute to developing the National Policy on Care for the Aging.Research Design
This chapter provides an overview of the multi-faceted landscape of methods used to study the steering effects of the Sustainable Development Goals. After a discussion of the political use of science and the complex relations between science and politics, the chapter showcases a selection of different methods that are employed to trace the steering effects of the Sustainable Development Goals. Sel
System verification and validation are performed to secure that a system fulfils the different quality aspects, such as reliability, functionality, maintainability, performance and user friendliness. Since the verification and validation activities take a large share of the total project budget, efficiency and effectiveness are key issues. In this paper, a method is presented for application of th
The impacts of adverse weather conditions on railway systems can lead to large delays and cancellationsacross the entire network. In this paper, we aim to understand the relationship between weather andtrain disruptions (i.e. cancellations and large delays) across the entire Swedish railway network for theyears 2011-2019. Using railway operations data and snow depth, temperature, precipitation, an
Surface plasmon resonance, i.e. detection of changes in refractive index on a surface, was used in a biosensor to evaluate the dissociation/association rate and affinity constants of human monoclonal IgG and IgM antibodies and Tab fragments. The results showed that an observed difference in affinity constants between intact and fragmented IgG anti-tetanus antibody was related to approximately 10-f
The intact SP6 χ promoter stimulated transcription 30 times more efficiently than did a control promoter consisting of a TATA motif as the only promoter element. Mutation of the SP6 χ promoter decamer in two positions reduced the transcriptional stimulation activity by over 90%. Promoters containing the SP6 χ promoter octamer or a consensus octamer in front of a TATA box were ineffective immunoglo
High-risk neuroblastoma (NB) is a significant clinical challenge. MYCN and Anaplastic Lymphoma Kinase (ALK), which are often involved in high-risk NB, lead to increased replication stress in cancer cells, suggesting therapeutic strategies. We previously identified an ATR (ataxia telangiectasia and Rad3-related)/ALK inhibitor (ATRi/ALKi) combination as such a strategy in two independent genetically
Anti-competitive notions, it seems, are increasingly informing the critical debate on a data-driven economy organised into scalable digital platforms. Issues of market definitions, how to value personal data on multisided platforms, and how to detect and regulate misuses of dominant positions have become key nomenclature on the battlefield of addressing fairness in our contemporary digital societi
Objectives: To investigate whether changes in complete blood count (CBC) in islet autoantibody positive children with increased genetic risk for type 1 diabetes are associated with oral glucose tolerance tests (OGTT) and HbA1c over time. Methods: The Environmental Determinants of Diabetes in the Young (TEDDY) study follows children with increased risk for type 1 diabetes in the United States, Germ
This chapter investigates how reports in Swedish mainstream media framed the 1980s peace movement collective actions in Sweden. By revisiting press coverage of protest events, the analysis identifies the central characteristics of the framing. Primarily, the protests are found to be framed in positive terms and successfully conveyed what Charles Tilly and others have noted as key for a social move
This chapter is a commentary on Principle 1 of the Principles for Responsible Contracts (PRC). The PRC were endorsed by the United Nations Human Rights Council in 2011 alongside the United Nations Guiding Principles on Business and Human Rights. The PRC were drafted because of the potential for investment contracts to act as an instrument through which States and businesses could affect the human
