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Aducanumab, a human IgG1 antibody with plaque-clearing effects and modest clinical benefit, binds selectively to aggregated Aβ via the N-terminal region. Yet, the molecular details of how the antibody engages Aβ1-42 fibrils remain unresolved. Using magic-angle spinning NMR, we show that binding of aducanumab preserves the overall architecture of the Aβ1-42 fibril core while inducing significant st

This paper firstly proposes a simple yet efficient generalized approach to apply differential privacy to text representation (i.e., word embedding). Based on it, we propose a user-level approach to learn personalized differentially private word embedding model on user generated contents (UGC). To our best knowledge, this is the first work of learning user-level differentially private word embeddin

In this work, we present a simple yet effective framework to address the domain translation problem between different sensor modalities with unique data formats. By relying only on the semantics of the scene, our modular generative framework can, for the first time, synthesize a panoramic color image from a given full 3D LiDAR point cloud.The framework starts with semantic segmentation of the poin

Cleveland (1979) is usually credited with the introduction of the locally weighted regression, Loess. The concept was further developed by Cleveland and Devlin (1988). The general idea is that for an arbitrary number of explanatory data points x_i the value of a dependent variable is estimated ŷ_i. The ŷ_i is the fitted value from a dth degree polynomial in x_i

This paper describes an 8-Bit, 100-MHz current steering CMOS low glitch interpolation digital to analog converter (DAC). It includes a 16-tap voltage controlled delay line and 8-Bit based linear interpolators, making the effective clock rate up to 1.6-GHz. With the linear interpolation, the requirement on the analog reconstruction filter is relaxed, and low glitch digital to analog conversion is a

A widely researched aspect of Aldous Huxley’s work is his later years’ advocacy for psychedelic drugs, in which he came to develop a strong psychological and philosophical interest. While the early novel Brave New World (1932) presented the fictional ‘perfect drug’ soma in dark, authoritarian tones, the autobiographical essay The Doors of Perception (1954) evaluated the experience of mescalin ther

Political discourse has been and remains a central topic of scholarly inquiry due to its role in shaping public opinion, ideologies, and social interactions. It constitutes a highly polysemiotic form of communication in which hand expressions play a central role in the organisation and interpretation of interactions. This thesis investigates hand expressions in televised political discourse from

This thesis analyzes how Denmark and Sweden frame and respond to men’s violence against women in national action plans from 2020–2025. The study is significant because Denmark and Sweden are internationally recognized as highly gender-equal societies while simultaneously experiencing persistent levels of gender-based violence, a phenomenon known as the Nordic Paradox. Using Feminist Security Studi

We describe the implementation of a FrameNet-based semantic role labeling system for Swedish text. To train the system, we used a semantically annotated corpus that was produced by projection across parallel corpora. As part of the system, we developed two frame element bracketing algorithms that are suitable when no robust constituent parsers are available. Apart from being the first such system

The study of psychosocial is highly relevant for project-based sector like construction owing to the following justifications: mobility of workers, constant change of workplace, diversity of work performed, physically demanding, high health and safety risk, meeting deadlines, monetary constraints and male-dominated industry. All these factors contribute to the industry having unique and different

We wanted to investigate if plasma levels of antimicrobial polypeptides (AMPs) are increased in severe sepsis and if they correlate with severity and mortality. Samples were collected from 31 sepsis patients at the intensive care unit. The Sequential Organ Failure Assessment (SOFA) score and 90-day mortality were registered, and inflammatory markers and AMP levels were measured by ELISA. A median