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The Sanfilippo syndrome type B is a lysosomal storage disorder caused by deficiency of alpha-N-acetylglucosaminidase; it is characterized by profound mental deterioration in childhood and death in the second decade. For understanding the molecular genetics of the disease and for future development of DNA-based therapy, we have cloned the cDNA and gene encoding alpha-N-acetylglucosaminidase. Clonin
Isothermal titration calorimetry is increasingly becoming a common tool for the investigation of surfactant association processes. This can be associated with the development of new, sensitive and easy-to-operate commercial equipment, allied with the advantage of producing simultaneous information on the main thermodynamic parameters associated with the process under investigation. However, a sign
Autoantibodies to the non-collagenous (NC1) domain of the alpha 3(IV)-chain of type IV collagen are found in sera from patients with anti-GBM nephritis. These antibodies have been shown to be pathogenic. In this study the antibody specificity has been investigated in patients with Goodpasture's syndrome and from a patient with atypical anti-GBM antibodies, recognizing the alpha 1(IV)-chain only. O
Antibodies provide some protection against cytomegalovirus-mediated disease. All aspects of antibody recognition of important viral antigens are however not fully appreciated. Glycoprotein B (gB), a key protein in the viral membrane, participates in viral infection and it is a component of prototype vaccines. By using combinatorial antibody library and selection technology, novel antibody specific
Large international biobank studies can make substantial contributions to scientific research by validation of the biological importance of previous research and by identification of previously unknown causes of disease. However, regulations for patient consent that are too strict and discrepancies in national policies on informed consent might hinder progress. Therefore, establishment of common g
We investigate the observed depletion of red giants in the cores ofpost-core-collapse globular clusters. In particular, the evolutionaryscenario we consider is a binary consisting of two low-mass stars whichundergoes two common-envelope phases. The first common-envelope phaseoccurs when the primary is a red giant resulting in a helium white dwarfand main-sequence star in a detached binary. The sec
The Gauss-Lagrange stochastic wave model is known to produce irregular waves with realistic degrees of asymmetry. We present the basic structure of the model and illustrate three of its characteristic properties: front-back asymmetry, particle orbits, and average horseshoe pattern. We also study the effect of a linear filter in a wave energy converting (WEC) system on asymmetry and on average powe
High-power operation of conventional GaN-based light-emitting diodes (LEDs) is severely limited by current crowding, which increases the bias voltage of the LED, concentrates light emission close to the p-type contact edge, and aggravates the efficiency droop. Fabricating LEDs on thick n-GaN substrates alleviates current crowding but requires the use of expensive bulk GaN substrates and fairly lar
In this work, 22 sets of cutting data and tool life for longitudinal turning of steel are analyzed using the Colding equation. When modeling tool life with a limited number of tool performance data points, the model error may be low for these points. Evaluating the model for test points not used when computing the model coefficients may give larger errors for these points. This work proves that th
Goda kamrater, ett antal buteljer punsch, en droska, och en likkista av barnmodell – vad är det värsta som kan hända? I lundastudenten Carl Lindells fall slutade det riktigt illa, med både tidningsskriverier och rektorsförhör. Arkivarien vid universitetsarkivet Henrik Ullstad berättar historien om en Malmöutflykt på 1880-talet som tog en ände med förskräckelse.Good companions, numerous bottles of punsch, a carriage and a child-sized coffin – what could possibly go wrong? In the case of Lund student Carl Lindell, it all went horribly wrong, with stories in the newspapers and being taken before the vice-chancellor. University Library archivist, Henrik Ullstad, tells the story of a Malmö excursion in the 1880s that came to an alarming end.
Investigations mapped the region(s) on the light chain of high molecular weight kininogen (HK) that participates in cell binding. Sequential and overlapping peptides of domain 5 (D5(H)) were synthesized to determine its cell binding site(s). Three peptides from non-overlapping regions on D5(H) were found to inhibit biotin-HK binding to endothelial cells. Peptides GKE19 and HNL21 weakly inhibited b
Implementing electrically connected metal-coated posts in a Deterministic Lateral Displacement (DLD) device and applying electric fields, we use electrokinetics to achieve tunable particle separations and to trap and manipulate DNA. The strength of DLD stems from its typically binary behavior. Particles move in one out of two trajectories based on their effective size. For particles that are close
Most students of politics are familiar with Carl Schmitt’s definition of politics as a friend-enemy distinction. Yet, only few know of alternative conceptions of politics in interwar Germany that emphasize cooperation and legality over confrontation and decisionism. To unlock such views, this article examines the work of Hermann Heller, a social-democratic constitutional theorist, and takes a clos
Due to the disruptive role of the Bitcoin in the financial sector, both scholars and practitioners are increasingly wondering whether it is possible to replicate the impact of the Blockchain technology in the supply chain context. As a distributed ledger technology characterized by the decentralized consensus, Blockchain is touted by many as the proper platform to collect all the information about
