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Secretory lysosomes of natural killer (NK) cells combine storage, regulated secretion and lysosomal activity. We asked whether one could target exogenous proteins to the secretory lysosomes of NK-cells for final delivery into a tumor site upon degranulation. cDNAs for both soluble and transmembrane (tm) proteins were expressed in the human YT-Indy NK-cell line. Targeting of a soluble TNF receptor

We describe a test which uses the ability of viable cells to reduce 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) to detect resistance to a bactericidal drug, rifampin, in in vitro-cultured Mycobacterium tuberculosis. The assay shows a linear relationship between the number of viable bacteria and the ability to reduce MTT. Dead mycobacteria were unable to reduce MTT. Rifampin

Numerous polymerase chain reaction (PCR)-based methods have been developed and used increasingly to screen vertebrate blood samples for the diagnosis of haemosporidian blood parasites (Sporozoa, Haemosporida), but a rigorous evaluation of the sensitivity of these methods for detecting mixed infections of different haemosporidian species belonging to the same and different genera and subgenera is l

Background: Aspirin is recommended for secondary prevention after transient ischaemic attack (TIA) or ischaemic stroke on the basis of trials showing a 13% reduction in long-term risk of recurrent stroke. However, the risk of major stroke is very high for only the first few days after TIA and minor ischaemic stroke, and observational studies show substantially greater benefits of early medical tre

The discovery that variants in the melatonin receptor 2 (MTNR1B) gene were associated with glucose levels, insulin secretion, and risk for type 2 diabetes (T2D) in genome-wide association studies (GWAS) reinforced the previously suggested link between glucose homeostasis and circadian rhythmicity. Diurnal secretion of melatonin has reported to be altered in people with diabetes and rodent models o

On the basis of two points of departure: (1) no state has clean hands and (2) the types of crime a state commits vary with state formations, this article explores cases where the Swedish state and its agencies have been held responsible for some form of wrongdoing. Drawing on a total of 8,561 judgments issued against the state by agencies of control (the Parliamentary Ombudsman, the Chancellor of

This article explores civic engagement with the Danish/Swedish crime series The Bridge (Danmarks Radio/Sveriges Television 2011–) based on qualitative interviews with 113 audience members, and drawing on the notion of cultural citizenship. The perspective of cultural citizenship, as understood and operationalized mainly by Hermes, is married with critical perspectives on the crime drama genre and

Objectives: To describe the housing situation and aspects of participation among older adults living with long-standing spinal cord injury (SCI) with attention to SCI severity, and to examine whether and how objective housing accessibility (based on objectively measurable criteria) is associated with aspects of participation. Design: Cross-sectional study utilizing the assessment tools Impact on P

We have created devices that are extremely simple to fabricate, function without pumps, are reusable and capable of dealing with very large differences in particle sizes without clogging. Our new approach to microfluidic particle sorting is precise enough for applications in blood fractionation, cancer cell sorting, parasite detection and sample decomplexing in general. We achieve this using Deter

INTRODUCTION: Several lines of evidence indicate that increased inflammation is associated with Post-Traumatic Stress Disorder (PTSD). We have previously reported that peripheral inflammatory markers are significantly higher in combat-exposed veterans with than without PTSD. This study was designed to replicate these findings in a new study cohort using the same population and recruitment strategi

Background: Use of bio-based diesel is increasing in Europe. It is currently produced from oilseed crops, but can also be generated from lignocellulosic biomass such as straw. However, removing straw affects soil organic carbon (SOC), with potential consequences for the climate impact of the biofuel. This study assessed the climate impacts and energy balance of biodiesel production from straw usin

Sweden was historically, and remains, a high-migration country. The chapter considers its experience using the census and population register data that are available for the analysis of migration over long historical periods, assessing their strengths and weaknesses. It then outlines levels of inter-parish moves from 1900 to 2015 as well as moves over shorter distances from the 1970s. The former o

The adult adaptive immune system is comprised of a wide spectrum of lymphocyte subsets with distinct antigen receptor repertoire profiles, effector functions, turnover times and anatomical locations, acting in concert to provide optimal host protection and self-regulation. While some lymphocyte populations are replenished by bone marrow hematopoietic stem cells (HSCs) through adulthood, others eme

We describe the implementation of a FrameNet-based semantic role labeling system for Swedish text. To train the system, we used a semantically annotated corpus that was produced by projection across parallel corpora. As part of the system, we developed two frame element bracketing algorithms that are suitable when no robust constituent parsers are available. Apart from being the first such system

The study of psychosocial is highly relevant for project-based sector like construction owing to the following justifications: mobility of workers, constant change of workplace, diversity of work performed, physically demanding, high health and safety risk, meeting deadlines, monetary constraints and male-dominated industry. All these factors contribute to the industry having unique and different

A widely researched aspect of Aldous Huxley’s work is his later years’ advocacy for psychedelic drugs, in which he came to develop a strong psychological and philosophical interest. While the early novel Brave New World (1932) presented the fictional ‘perfect drug’ soma in dark, authoritarian tones, the autobiographical essay The Doors of Perception (1954) evaluated the experience of mescalin ther

Political discourse has been and remains a central topic of scholarly inquiry due to its role in shaping public opinion, ideologies, and social interactions. It constitutes a highly polysemiotic form of communication in which hand expressions play a central role in the organisation and interpretation of interactions. This thesis investigates hand expressions in televised political discourse from