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BACKGROUND. Hypoxia induces increased tumor growth by promoting angiogenic and glycolytic pathways. Tumors expressing hypoxia-inducible factor-la (HIF-1 alpha), an important transcriptional activator of oxygen-regulated genes, are resistant to chemotherapy and radiotherapy. The major challenge in prostate cancer therapy today is to gain a better understanding of the development of hormone-refracto
The healthy vaginal ecosystem is maintained by the interaction of the vaginal epithelium and the microflora, where lactobacilli and occasionally bifidobacteria play an important role. Imbalances in the dominance of lactobacilli may lead to bacterial vaginosis or yeast vaginitis. Probiotics may be a means to secure a favourable microbial balance in the vagina and, as the normal vaginal flora ascend
The purpose of this study was to create and evaluate personalised virtual learning spaces (PVLSs) in a course that was previously delivered face-to-face only. The study addressed three related questions: (1) Can a PVLS successfully be introduced into a course where IT has not previously featured? (2) Can the PVLSs be used to enhance the assessment from an extended essay to a higher-level empirical
The paper presents some preliminaryresults on dynamic scheduling of model predictive controllers (MPCs).In an MPC, the control signal is obtained by on-line optimization of acost function, and the MPC task may experience very large variationsin execution time from sample to sample. Unique to this application,the cost function offers an explicit, on-line quality-of-servicemeasure for the task. Base
We present a method for the estimation of the distribution of the quasi-static hogging-bending moment for a floating body. Starting points of this study are temporal characteristics of the sea state. The approximation is deduced from the estimation of the joint distribution of crest amplitude and crest length. The quality of the model is investigated by comparing computed distributions with empiri
A modern hearing aid should be aesthetically appealing as well as offer sufficient and adequate signal amplification. Due to the small physical size of these devices, acoustical feedback (howling) is a major problem. Apart from the annoyance and potential hearing damaging effects that howling implies, it also reduces the supplied maximum Real Ear Aided Gain (REAG). This paper proposes a novel method
Bone marrow resident hematopoietic stem cells differentiate into all different types of lymphoid populations, there among mature naive B cells expressing IgM and IgD. During the maturation, the B cells are subjected to several steps of selection to ensure proper development of the antigen receptor. The mechanisms regulating the selection are to great extent unknown. In paper I of this thesis, we d
Popular Abstract in Swedish Tyfoidfeber är en sjukdom som orsakas av bakterien Salmonella typhi. Denna bakterie, som sprids via vatten eller föda, orsakar buksmärtor, feber och illamående. Om infektionen inte behandlas med antibiotika, kan bakterien sprida sig till blodet och leda till döden. Årligen rapporteras 16 miljoner fall av salmonella i världen och av dessa får ungefär 600 000 dödlig utgånThis study investigates the interaction between dendritic cells (DC) and the Gram negative intracellular bacterium Salmonella typhimurium. Using in vitro and in vivo approaches, the capacity of DC to directly and indirectly present antigens from Salmonella-infected cells, cytokine production by infected DC, and activation of bacteria-specific T cells was analyzed. These studies revealed differenti
BACKGROUND: Bisphosphonates have profound effects on bone physiology, and could modify the process of metastasis. We undertook collaborative meta-analyses to clarify the risks and benefits of adjuvant bisphosphonate treatment in breast cancer.METHODS: We sought individual patient data from all unconfounded trials in early breast cancer that randomised between bisphosphonate and control. Primary ou
This article is divided into two parts. In the first part, preliminary reports on the archaeological work conducted at the sanctuary during the years 2012 and 2013 is presented, and in the second part, two conservation projects are discussed. The first part includes a description of the excavations at the Split Rock by Lars Karlsson, an account of the excavations on the slope of the Monumental Tom
Two-dimensional electronic spectroscopy (2D) has been applied to beta-carotene in solution to shine new light on the ultrafast energy dissipation network in carotenoids. The ability of 2D to relieve spectral congestion provides new experimental grounds for resolving the rise of the excited state absorption signal between 18,000 and 19,000 cm(-1). In this spectral region, the pump-probe signals fro
BACKGROUND: A large proportion of adult survivors of cardiac arrest have a poor neurological outcome. Guidelines recommend multimodal neuro-prognostication no earlier than 72-96 hours after cardiac arrest. There is great interest in earlier prognostic markers, including very early markers at admission. The novel blood biomarkers proenkephalin A 119-159 (penKid), bioactive adrenomedullin (bio-ADM)
In recent decades, there has been a global recognition of the co-constitutive relationship between gender justice and peaceful transformation of previously war-torn societies. This chapter investigates how “women-friendly states” have located their foreign policies within notions of gender equality and empowerment. It focuses on how feminist foreign policy is to all intents and purposes ethical an
The chapter engages with the so-called Swedish Model in the country of its invention: Sweden. First, it examines feminist thought that has supported the implementation of this legislation. Next, it looks at the effects of this law according to 12 key informants and 25 male sex workers. Ultimately, the criminalization of sex work in Sweden is so focused on women selling sex to men that police and p
