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Astrocytes form functionally and morphologically distinct populations of cells with brain-region-specific properties. Human pluripotent stem cells (hPSCs) offer possibilities to generate astroglia for studies investigating mechanisms governing the emergence of astrocytic diversity. We established a method to generate human astrocytes from hPSCs with forebrain patterning and final specification wit
The chapter investigates how one specific collaboration between a fashion conglomerate (Louis Vuitton) and a contemporary artist (Takashi Murakami) exemplifies a wider phenomenon of the ways in which brands curate artists to fit their own needs. Central to the chapter is the discussion about why and to what ends curation of art has become important for fashion brands in their branding efforts.
Purpose: The eyelid is commonly dissected and divided in the process of, for example, blepharotomy, entropion repair, or when preparing a full-thickness eyelid flap to reconstruct a tumor defect. No study has yet been conducted to examine how perfusion in an eyelid is affected by dissection, using modern imaging techniques. Methods: The eyelid was divided with a 10-mm vertical incision, 5 mm from
Background: Previous studies from our and other centers on young patients with type 1 diabetes (T1D) have indicated pro-atherosclerotic changes in the carotid arteries and in the lipid and systemic inflammatory profiles without a clear relationship between these changes and the hyperglycemic control. We have also earlier found in these patients a certain HLA-related genetic susceptibility to adver
This article explores four preselected permanent magnet synchronous machine (PMSM) topologies suitable for direct mounting on low pressure spool in a turbo fan engine. The challenge of contributing to More Electric Engine (MEE) development is that the electrical machine needs to operate over wide speed range, take advantage of available space that forces to use a high number of poles and last but
Preclinical assessment of the therapeutic potential of dopamine (DA) neuron replacement in Parkinson's disease (PD) has primarily been performed in the 6-hydroxydopamine toxin model. While this is a good model to assess graft function, it does not reflect the pathological features or progressive nature of the disease. In this study, we establish a humanized transplantation model of PD that better
For centuries antiquarians and archaeologists have tried to reconcile the terminology of ancient writers on architecture, such as Vitruvius, with the perceived realities of the material record. One particular issue of debate concerns the interpretation of different words for "brick" in Latin. In this paper it is argued that earlier attempts to settle this question are unsatisfactory and leave seve
Background Dehydroepiandrosterone (DHEA) and its sulfated ester DHEA-sulfate (DHEA-S), (together DHEA[S]), are the most abundant adrenal steroids in humans and are found in blood and the brain, where they function as neurosteroids with direct receptor affinities. Preclinical studies suggest that DHEA(S) has antidepressant/neuroprotective properties, and exogenously administered DHEA has shown anti
We have built an array of vertical nanotubes connected by a subsurface nanofluidic channel. The nanotube system is to be used for cell injections. By culturing cells on top of the nanotubes the cells will be pierced and molecules can enter the cells via the subsurface channel. Several channels can be made on the same sample and different molecules can be injected into different subpopulations of c
Background. Alcohol use disorders are a major health problem, often with a chronic course. Studies on remission from alcohol use disorders are sparse. Objective. The aim of this study was to analyse the rate of remission from AUD and the possible influence of other mental disorders and sociodemographic factors on the remission in the Lundby Cohort. Method. Remission from AUD was studied for 312 ma
Infectious diseases are the primary cause of mortality worldwide. The dangers of infectious disease are compounded with antimicrobial resistance, which remains the greatest concern for human health. Although novel approaches are under investigation, the World Health Organization predicts that by 2050, septicaemia caused by antimicrobial resistant bacteria could result in 10 million deaths per year
Old age is associated with an enhanced susceptibility to stroke and poor recovery from brain injury, but the cellular processes underlying these phenomena are not well understood. Potential mechanism underlying functional recovery after brain ischemia in aged subjects include neuroinflammation, changes in brain plasticity-promoting factors, unregulated expression of neurotoxic factors, or differen
This study analyzes transformations in institutions of affordable housing production connected to neoliberalization, which have impacted affordability rates and income gaps in Copenhagen and Istanbul. Also, different types of affordable housing began to develop, such as modular housing of Almenbolig+ in Copenhagen and housing for very low-income people in Istanbul. Increased affordability rates ar
FELs are well known for generating highly coherent light with excellent brilliance. In order to improve FEL coherence we have to follow how coherence evolves along the undulator and determine the factors that influence it the most. This paper presents qualitative coherence features that shine new light on the importance of coherence studies in the design of an FEL. By simulating and then analyzing
