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Immunotherapy, which involves strategies to activate, enhance or redirect immune responses to achieve long-lasting immunity, has the potential to play an important role in the treatment of a variety of diseases. This thesis, based on four original papers, highlights different approaches to modulate immune responses by specific targeting of antigen-presenting cells. The first two studies focuses o

After World War I, millions of men went back from the war front promised of land, work and social justice, but their expectations were unfulfilled by the governments of European countries. In this context, the political landscape was enriched of new ideas, and several new parties, movements and associations born across Europe. In Italy, ANMIG (Disabled Ex-Servicemen National Association) was

The European Union has a low-carbon roadmap that aims at reducing greenhouse gas emissions toprevent further climate change and achieve climate-neutrality by 2050. Many of the historical buildings that wehave today will still be around in 2050. Hence, there is a need to improve their energy performance. A way to dothis is to use hemp-lime as a material for renovation. Hemp shiv, the woody core par

BACKGROUND: Cancer-associated fibroblasts (CAFs) are molecularly heterogeneous mesenchymal cells that interact with malignant cells and immune cells and confer both anti- and pro-tumorigenic functions. Prior in situ profiling studies of human CAFs have largely relied on scoring single markers, thus presenting a very limited view of their molecular complexity. Our objective was to study the complex

Acoustic trapping is becoming increasingly popular as a tool to isolate and enrich biological nanoparticles [1] (particularly extracellular vesicles [2]), yet an inherent problem with acoustic trapping of nanoparticles is calibration of the trapping efficiency. This abstract presents in-house synthesized nanoparticles with different sound scattering properties, either rigid high density gold nanop

Human monoclonal antibodies specific for human cytomegalovirus (CMV) antigens have been established using peripheral blood lymphocytes from a seropositive donor. Immortalization of antigen-specific B cells was achieved by Epstein-Barr virus transformation followed by somatic cell fusion of antigen-specific lymphoblastoid cells. Four clones producing high-affinity antibodies (0.2-7 × 109 M-1) speci

Avsikten med detta projekt har varit att utveckla väl fungerande rutiner för PIXE-analys av biologiska prov med anknytning till exponering i arbetsmiljösituationer. Kravet på metoderna är att de tillvaratar PIXE-metodens fördelar (multielementanalys, små prov, snabb analys, låga detektionsgränser) och samtidigt förändrar eller förstör så lite som möjligt av den information som finns i de ursprungl

Abstract is not available

The surface of the ocean, and so such quantities as the significant wave height, can be thought of as a random surface in space which develops over time. In this paper, we explore certain types of random fields (in space and time) as models for the significant wave height and fit these models to data obtained from the TOPEX-Poseidon satellite. The data consist of observations along different one-d

Diabetes is a much more heterogeneous disease than the present subdivision into types 1 and 2 assumes; type 1 and type 2 diabetes probably represent extremes on a range of diabetic disorders. Both type 1 and type 2 diabetes seem to result from a collision between genes and environment. Although genetic predisposition establishes susceptibility, rapid changes in the environment (ie, lifestyle facto

Non-stretched laminar burning velocities, SL, of acetaldehyde + air mixtures at initial gas mixture temperatures, T, of 298, 318, 338, 348 and 358 K are reported for the first time. The flames were stabilized on a perforated plate burner at 1 atm using the heat flux method at conditions where the net heat loss from the flame to the burner is zero. Uncertainties of the measurements were analyzed an

Lipid bilayers containing 5% nitrilotriacetic acid (NTA) lipids supported on SiO2 have been used as a template for immobilization of oligohistidine-tagged single-chained antibody fragments (scFvs) directed against cholera toxin. It was demonstrated that histidine-tagged scFvs could be equally efficiently coupled to an NTA-Ni2+-containing lipid bilayer from a purified sample as from an expression s

Popular Abstract in Swedish I de flesta reglerproblem är syftet att hålla utsignalen nära ett önskat värde trots störningar som påverkar systemet. Ibland är det bästa referensvärdet inte känt i förväg. I stället skall det hittas i realtid för att optimera systemets prestanda. Denna avhandling behandlar en så kallade probing-strategi som kan tillämpas för denna klass av problem. Fokus ligger i tillIn most control problems the objective is to control the output at a desired value in spite of disturbances. In some cases, the best setpoint is not known a priori and it should be found online to optimize the process performance. This thesis examines a probing strategy that can be applied for this class of problems. The focus is on the application of the technique to the control of feed supply in

The rapid progress in scanning probe microscopy (SPM) techniques in the last decade has induced an increasing need for manufacturing advanced SPM tips. One important case is conductive and transparent tips. For such tips, only a few techniques have been proposed. which are either expensive or have poor reproducibility. We here propose a simple and cheap sol-gel technique to prepare fibers with a s