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The variable outcome to standard immunochemotherapy for mantle cell lymphoma (MCL) patients is a clinical challenge. Established risk factors, including high MCL international prognostic index (MIPI), high proliferation (Ki-67), non-classic (blastoid/pleomorphic) morphology, and mutated TP53, only partly identify patients in need of alternative treatment. Deepened understanding of biological facto
Following an industrial boom from the mid-to-late 19th century, Glasgow’s East End underwent exceptional levels of industrial decline. By the 1960s, it suffered from wholesale abandonment and devaluation, visible through widespread swathes of vacant and derelict land and decrepit building structures. After several unsuccessful regeneration attempts over the decades, in 2007 Glasgow City Council (G
Objectives: To compare the atrial fibrillatory rate (AFR) derived from a local right atrial intracardiac recording (RA-FR) and from a single-lead surface electrocardiogram (ECG) during atrial fibrillation (AF) and to evaluate the correlation with transvenous electrical cardioversion (TVEC) threshold (in Joules), number of shocks and cardioversion success rate in horses. Animals: ECGs and clinical
Introduction/Aim of the Study. One way of investigating health trends at the population level is to study the physical performance and functional ability in different birth cohorts. The information obtained can be used to predict illness, disability, and future needs for care. However, contradictory findings have been reported when comparing the physical performance of older adult birth cohorts. T
Extracts of Diprion similis females contained about 15 ng of the sex pheromone precursor 3,7‐dimethylpentadecan‐2‐ol per female. After derivatisation with (S)‐2‐acetoxypropanoyl chloride, we found that the major stereoisomer in the extract was (2S,3R,7R)‐3,7‐dimethylpentadecan‐2‐ol. Small amounts of other stereoisomers of 3,7‐dimethylpentadecan‐2‐ol were also identified in the extract, namely 1% o
BACKGROUND: Osteonecrosis of the jaw (ONJ) is an adverse effect of antiresorptive treatment. This study estimated incidence proportions and incidence rates of ONJ in cancer patients with bone metastases from solid tumors treated for the prevention of skeletal-related events in routine clinical practice.METHODS: This cohort study in Denmark, Norway, and Sweden in 2011-2018 included 3 treatment coho
The “realism of law” tried to dissolve the connections between justice as norm and justice as fact. A severe critic of Legal realism was Halvar G.F. Sundberg. He explained that the Church was not created by the State or its legal order, but the State and the legal order recognized the factual, existing Church as being also a legal institution. The State had no right to deal with the spiritual regi
Selective breeding for desirable traits in strictly controlled populations has generated an extraordinary diversity in canine morphology and behaviour, but has also led to loss of genetic variation and random entrapment of disease alleles. As a consequence, specific diseases are now prevalent in certain breeds, but whether the recent breeding practice led to an overall increase in genetic load rem
Cigarette smoking is a crucial factor in the development and progression of multiple cancers including breast. Here, we report that repeated exposure to a fixed, low dose of cigarette smoke condensate (CSC) prepared from Indian cigarettes is capable of transforming normal breast epithelial cells, MCF-10A, and delineate the biochemical basis for cellular transformation. CSC transformed cells (MCF-1
Differential cross-sections for top-quark pair production, inclusively and in association with jets, are measured in pp collisions at a centre-of-mass energy of 13 TeV with the ATLAS detector at the LHC using an integrated luminosity of 140 fb−1. The events are selected with one charged lepton (electron or muon) and at least four jets. The differential cross-sections are presented at particle leve
Background: Randomized trials have demonstrated that early anticoagulation after acute atrial fibrillation-associated ischemic stroke is safe and non-inferior to delayed initiation. Whether anticoagulation should be delayed in people with larger infarcts is uncertain. Aims: To investigate whether ischemic stroke infarct volume, measured precisely by segmentation, modifies the treatment effect of e
This thesis examines if the investment strategy “Puppies of the Dow” is a working strategy applied to a European market setting during the years 2001-2010. The purpose was to determine whether the strategy could be successfully replicated in a different market with conditions differing from the once underlying the Dow Jones Industrial Average that the investment strategy originates from. By replic
Byggproduktion idag, innebär bland annat en hög energianvändning, utsläpp av växthusgaser, användning av miljöfarliga ämnen samt stora mängder avfall som måste hanteras. Detta är aspekter som samtliga behöver minskas för att reducera branschens stora miljöpåverkan. Inom byggsektorn har klimatarbetet fått en alltmer ökad uppmärksamhet med införandet av olika klimatkrav på nationell och EU-nivå. I oCarbon offsets, essential in climate-related aspirations for governments and businesses, entail reducing, avoiding, or extracting greenhouse gases from the atmosphere, even if not contemporaneous with emissions. They include, among others, energy-efficient solutions and renewable energy investments. These compensations, voluntary or regulated, must meet reliability criteria. Actions, such as Carbo
Studies show that employees are an organisation’s most important asset. Therefore, an employer needs to attract the desired future employees. Currently, core values appear frequently on employers’ websites. Core values could consequently operate as a part of external employer branding to attract candidates. The question remains whether core values matter to future employees when considering workin
Byggproduktion idag, innebär bland annat en hög energianvändning, utsläpp av växthusgaser, användning av miljöfarliga ämnen samt stora mängder avfall som måste hanteras. Detta är aspekter som samtliga behöver minskas för att reducera branschens stora miljöpåverkan. Inom byggsektorn har klimatarbetet fått en alltmer ökad uppmärksamhet med införandet av olika klimatkrav på nationell och EU-nivå. I oCarbon offsets, essential in climate-related aspirations for governments and businesses, entail reducing, avoiding, or extracting greenhouse gases from the atmosphere, even if not contemporaneous with emissions. They include, among others, energy-efficient solutions and renewable energy investments. These compensations, voluntary or regulated, must meet reliability criteria. Actions, such as Carbo
I EU-domstolens dom i FCE Bank menade EU-domtolen att ett tillhandahållande av en tjänst mellan ett huvudkontor och dess filial inte utgör en beskattningsbar transaktion då huvudkontoret och dess branch, tillsammans, utgör en och samma beskattningsbara person.Tio år senare dömde EU-domstolen i Skandia America där EU-domstolen menade att den princip som härrör från domen i FCE Bank inte är tillämplIn its ruling in FCE Bank, the CJEU stated that a supply between a head office and its branch does not constitute a taxable transaction since the head office, together with its branch, constitute one taxable person. Ten years later the CJEU ruled in Skandia America stating that the principle deriving from FCE Bank is not applicable when the branch is a member of a VAT group. This ruling generated
Åldern för jordens inre kärna är en gåta som har förbryllat forskare i många decennier. Allt från en ålder lika hög som jordens magnetfält (mellan 3,5 och 4,2 Ga) i den ena änden, ner till 0,5 Ga i den andra änden. Eftersom den inre kärnan existerar på en fullkomligt oåtkomlig plats i jordens innersta centrum, medför detta självklara svårigheter när det kommer till direkta observationer (med seismThe age of the Earth's inner core is an enigma that has puzzled scientists for many decades. Everything from an age as high as the Earth's magnetic field (between 3.5 and 4.2 Ga) at one end, down to 0.5 Ga at the other end. Since the inner core exists in a completely inaccessible place in the innermost center of the Earth, this presents obvious difficulties when it comes to direct observat
