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We have recently discovered that the ZZ zinc finger domain represents a novel small ubiquitin-like modifier (SUMO) binding motif. In this study we identify the binding epitopes in the ZZ domain of CBP (CREB-binding protein) and SUMO1 using NMR spectroscopy. The binding site on SUMO1 represents a unique epitope for SUMO interaction spatially opposite to that observed for canonical SUMO interaction
The Cambrian Alum Shale Formation in the Andrarum-3 core from Scania,southern Sweden, consists of black siliciclastic mudstone with minor carbonate intercalations. Four facies comprise three siliciclastic mudstones and one fine-grained carbonate. The facies reflect deposition along a transect from deep ramp to basin on a Cambrian shelf. The three mudstone facies contain abundant clay clasts and la
To estimate the prevalence of Danish RA patients currently on biologic monotherapy and compare the effectiveness and drug adherence of biologic therapies applied as monotherapy.
The aim of the study was to determine whether genetically raised fasting glucose (FG) levels are associated with blood pressure (BP) in healthy children and adolescents. We used 11 common genetic variants of FG discovered in genome-wide association studies (GWAS), including the rs560887 single-nucleotide polymorphism (SNP) located in the G6PC2 locus found to be robustly associated with FG in child
Activity in grafted human iPS cell–derived cortical neurons integrated in stroke-injured rat brain regulates motor behavior Activity in grafted human iPS cell–derived cortical neurons integrated in stroke-injured rat brain regulates motor behavior Sara Palma-Tortosaa,1, Daniel Torneroa,b,1 , Marita Grønning Hansena, Emanuela Monnia, Mazin Hajya, Sopiko Kartsivadzea,c, Sibel Aktaya, Oleg Tsupykov
https://www.regenerative-neurobiology.lu.se/sites/regenerative-neurobiology.lu.se/files/publication_in_pnas_6.pdf - 2026-07-25
Background: Infection is a serious adverse effect of prostate biopsy (P-Bx), and recent reports suggest an increasing incidence. Objective: The aim of this multinational multicentre study was to evaluate prospectively the incidence of infective complications after P-Bx and identify risk factors. Design, setting, and participants: The study was performed as an adjunct to the Global Prevalence Study
Background: To investigate hand bone loss (HBL) measured by digital X-ray radiogrammetry (DXR) in patients with early rheumatoid arthritis (RA) receiving different treatment regimens, and to evaluate if DXR change rates during the first 12 months correlate with radiological damage after 24 months. Methods: From the total SWEFOT trial population, 159 patients had hand radiographs correctly timed an
Background: Dietary fibre is fermented by the colonic microbiota to carboxylic acids (CA), with potential health effects associated in particular with butyric and propionic acid. Objective: To investigate the formation of CA in the hindgut of healthy rats fed dietary fibre from different fractions of wheat shorts, a by-product of the milling of wheat. Design: Rats were fed dietary fibre (80 g/kg f
Background: Familial adenomatous polyposis (FAP) is typically characterized by multiple colonic polyps and frequent extracolonic features. Whereas the number of colonic polyps has been linked to the APC gene mutation, possible genotype-phenotype correlations largely remain to be defined for the extracolonic manifestations. Methods: Full genomic sequencing combined with multiplex ligation-dependent
Vikten av resurseffektivitet i livsmedelskedjan är tydlig, eftersom denna sektor är en av de största bidragarna till negativ klimatpåverkan globalt. Målet med den här uppsatsen var att utforska sidoströmmar av mat inom livsmedelskedjan i Västra Götaland, för att kartlägga hur mycket som redan är täckt i statistiken och vilka luckor i datamaterialet som finns för framtida forskning att täcka. DessThe importance of resource efficiency in the food supply chain is clear, since this sector is one of the biggest contributors to the negative environmental impacts globally. This thesis project aimed to examine food side streams throughout the food supply chain in Västra Götaland, to map out how much has already been covered statistically and what gaps there are in the data for future research to
To analyse the behaviour of English loanwords in the Japanese language using corpus analysis is a relatively new field of research. The aim of this thesis is to add to this emergent field by attempting to discover if there are any differences in how English loanword nouns and their native Japanese/Sino-Japanese near synonym pairs are used in contemporary written Japanese. The thesis also tries to
This research investigates how Weather and Climate Information Services (WCIS) have been used by farmers in the Tattaguine district of Senegal, where rainfed agriculture faces challenges due to increasing climate variability. The study employed qualitative methods, including structured interviews, key informant interviews, and a focus group discussion. The findings reveal high WCIS use rates but l
Many physiological functions of the stomach depend on an intact mucosal integrity; function reflects structure and vice versa. Histamine in the stomach is synthesized by histidine decarboxylase (HDC), stored in enterochromaffin-like (ECL) cells, and released in response to gastrin, acting on CCK2 receptors on the ECL cells. Mobilized ECL cell histamine stimulates histamine H-2 receptors on the par
Cysteine-rich secretory protein 3 (CRISP-3; also known as SGP28) was originally discovered in human neutrophilic granulocytes. We have recently developed a sensitive sandwich enzyme-linked immunosorbent assay for CRISP-3 and demonstrated the presence of CRISP-3 in exocrine secretions. To investigate the subcellular localization and mobilization of CRISP-3 in human neutrophils, we performed subcell
Cell surface heparan sulfate proteoglycans (HSPGs), syndecans and glypicans, play crucial roles in the functional properties of cancer cells, such as proliferation, adhesion, migration and invasion. Platelet-derived growth factor (PDGF)/PDGF receptor (PDGF-R) mediated signaling, on the other hand, is highly associated with cancer progression. Specifically, PDGF-Rα and PDGF-Rβ expressions documente
To investigate the hemodynamic profile associated with different target temperatures and to assess the prognostic implication of inotropic/vasopressor support and mean arterial pressure after out-of-hospital cardiac arrest. There is a lack of information how different target temperatures may affect hemodynamics.
Aims: To evaluate the impact of β-cell function on the efficacy of lixisenatide, a once-daily prandial glucagon-like peptide-1 receptor agonist, in patients with type 2 diabetes (T2D). Materials and methods: In this post hoc analysis, patients from the Phase 3 GetGoal-M and GetGoal-S clinical trials randomized to lixisenatide 20. μg once daily were stratified into quartiles by baseline β-cell func
