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The leukocyte complexity and mutational landscape of periampullary adenocarcinoma. Morphology matters.

Background: Periampullary adenocarcinomas are a heterogenous group of tumours with poor prognosis that hasnot improved considerably the last decades. Tumour morphology, i.e. intestinal type (I-type) or pancreatobiliarytype (PB-type), has been demonstrated to be a more relevant prognostic factor than anatomical origin. Tumourinfiltrating immune cells are vital in shaping the natural progress of canBackground: Periampullary adenocarcinomas are a heterogenous group of tumours with poor prognosis that hasnot improved considerably the last decades. Tumour morphology, i.e. intestinal type (I-type) or pancreatobiliarytype (PB-type), has been demonstrated to be a more relevant prognostic factor than anatomical origin. Tumourinfiltrating immune cells are vital in shaping the natural progress of can

A mapping study of employee-driven innovation: Suggesting future avenues of research

Eftersom innovation ger konkurrensfördelar, ökar marknadsandelar och påskyndar den övergripande institutionella tillväxten, utgör innovation en erkänd framgångsfaktor för organisationer. Under det senaste decenniet har ett paradigmskifte från traditionella innovationsstudier, med fokus på forskning och utveckling, till medarbetardriven innovation (EDI) skett. Då den senaste litteraturkartläggningeInnovation is widely recognized as a critical factor of organizational success as it cultivates competitive edge, augments market share, and accelerates overall institutional growth. During the last decade, a paradigm shift from the traditional innovation studies, focusing on research and development (R&D), toward employee-driven innovation (EDI) has been observed. However, the last literature

A novel high mobility group box 1 neutralizing chimeric antibody attenuates drug-induced liver injury and postinjury inflammation in mice

Acetaminophen (APAP) overdoses are of major clinical concern. Growing evidence underlines a pathogenic contribution of sterile postinjury inflammation in APAP-induced acute liver injury (APAP-ALI) and justifies development of anti-inflammatory therapies with therapeutic efficacy beyond the therapeutic window of the only current treatment option, N-acetylcysteine (NAC). The inflammatory mediator, h

Assessing the viability of probiotic preparations with flow cytometry. A comparison of different methods

Ändrade levnadsvanor i västerländska länder har lett till en ökning av sjukdomar så som IBS, infektioner i mag- och tarmkanal och allergier. Det har dessutom observerats att mikrofloran förändrats och goda bakterier så som Limosilactobacillus reuteri försvunnit. Mag- och tarmkanalen har därmed förlorat sina goda soldater mot patogena fiender med dysfunktionell balans som resultat. Därför är det inThis master thesis work was performed in collaboration with BioGaia AB, a Swedish biotech- company producing probiotic supplements containing the bacteria Limosilactobacillus reuteri. The products provided by BioGaia contain live microorganisms. Therefore, a method suitable for the correct enumeration of living cells is crucial in probiotic samples and today the so-called plate count method is use