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Objective: There is a lack of real-life studies on interleukin-17 (IL-17) inhibition in psoriatic arthritis (PsA). We assessed real-life 6- and 12-month effectiveness (i.e., retention, remission, low disease activity [LDA], and response rates) of the IL-17 inhibitor secukinumab in PsA patients overall and across 1) number of prior biologic/targeted synthetic disease-modifying antirheumatic drugs (
Objective: The heterogeneity of systemic lupus erythematosus (SLE) constitutes clinical and therapeutical challenges. We therefore studied whether unrecognized disease subgroups can be identified by using autoantibody profiling together with HLA-DRB1 alleles and immunological and clinical data. Methods: An unsupervised cluster analysis was performed based on detection of 13 SLE-associated autoanti
Aims: Recent studies have suggested potential sex differences in treatment response to pharmacological therapies in heart failure (HF). We performed a systematic review and meta-analysis of studies comparing treatment effects between men and women with HF and reduced ejection fraction (HFrEF) using established guideline-directed medical therapy and other emerging pharmacological treatments. Method
Software development companies spend considerable time resolving bug reports. However, bug reports might be invalid, i.e., not point to a valid flaw. Expensive resources and time might be expended on invalid bug reports before discovering that they are invalid. In this case study, we explore the impact of invalid bug reports and develop and assess the use of machine learning (ML) to indicate wheth
We present a new world-coordinate tracking algorithm for road users seen from static surveillance cameras, denoted GUTS. It is based upon the previously published UTS method but simplifies and replaces parts allowing association logic to work in world coordinates, by using a novel convolutional neural network denoted SAMHNet to convert every detection into world coordinates. Experimental evaluatio
China is urbanizing at an unprecedented rate, but also accelerating the use of water resources and overloading of urban drainage systems. To analyze the impact of urbanization on the drainage-system health in Jinxi, a typical small case area in China, this study proposed an innovative methodological framework for evaluation and prediction based on statistical and modeling methods, which provides a
Objective: To describe maternal perception of the quality of maternal and newborn care (QMNC) in facilities in Norway during the first year of COVID-19 pandemic. Methods: Women who gave birth in a Norwegian facility from March 1, 2020, to October 28, 2021, filled out a structured online questionnaire based on 40 WHO standards-based quality measures. Quantile regression analysis was performed to as
The objective was to investigate the validity and reliability of a new instrument assessing sexual harassment at a public university in Sweden. In-depth interviews and focus group discussions resulted in a 10-item instrument, the ‘Lund University Sexual Harassment Inventory’ (LUSHI). A survey was sent to all staff, including PhD students, and students, with a response rate of 33% (n = 2736) and 32
Objectives Physical inactivity and sedentary behaviour are associated with higher breast cancer risk in observational studies, but ascribing causality is difficult. Mendelian randomisation (MR) assesses causality by simulating randomised trial groups using genotype. We assessed whether lifelong physical activity or sedentary time, assessed using genotype, may be causally associated with breast can
I Danmark reguleres det sociale område i høj grad af rammelovgivning, som uddelegerer myndighed, regulerer gennem formålsbeskrivelser og gør det muligt for såkaldte velfærdsprofessionelle at udøve skøn. Denne artikel undersøger, hvordan samspillet mellem velfærdsprofessionelles opfattelser og de ting, der på forskellig vis regulerer deres praksis, får betydning for konstruktionen af legalitet i de
In this paper we present the concept for a teleoperation system for semi-autonomous robotic boats using virtual reality. This system can be used for monitoring autonomous driving as well as for direct manual control. The integration of live sensor data is possible as well as the integration of past measurement results and their correct registration within the virtual representation. Initial field
We study dynamics in a network of interacting agents updating their binary states according to a time-varying threshold rule. Specifically, agents revise their state asynchronously by comparing the weighted average of the current states of their neighbors in the interaction network with possibly heterogeneous time-varying threshold values. Such thresholds are determined by an exogenous signal repr
Background: The number of pregnant women with congenital heart disease (CHD) is rising, and the disease poses increased risks of cardiovascular and obstetric complications during pregnancy, potentially impacting breastfeeding success. This study aimed to investigate breastfeeding in primiparous women with CHD compared to primiparous women without CHD, and to examine potential hindering factors for
Programming is a cognitively demanding exercise. In particular, today’s software development requires a collective effort of programmers and the orchestration of a complex programming infrastructure. As disruptive technologies emerge, e.g., AI and quantum computing, the programming practice is undergoing a change, facing an uncertain future that we may not be able to accurately predict but can env
We propose and study a weakly convergent variant of the forward-backward algorithm for solving structured monotone inclusion problems. Our algorithm features a per-iteration deviation vector, providing additional degrees of freedom. The only requirement on the deviation vector to guarantee convergence is that its norm is bounded by a quantity that can be computed online. This approach offers great
Background: Propionic acid fermentation from renewable feedstock suffers from low volumetric productivity and final product concentration, which limits the industrial feasibility of the microbial route. High cell density fermentation techniques overcome these limitations. Here, propionic acid (PA) production from glucose and a crude glycerol/glucose mixture was evaluated using Acidipropionibacteri
New particle formation via the ion-mediated sulfuric acid and ammonia molecular clustering mechanism remains the most widely observed and experimentally verified pathway. Recent laboratory and molecular level observations indicate iodine-driven nucleation as a potentially important source of new particles, especially in coastal areas. In this study, we assess the role of iodine species in particle
During recent years, research on authenticated encryption has been thriving through two highly active and practice-motivated research directions: provably secure leakage-resilience schemes and key- or context-commitment security. However, the intersection of both fields had been overlooked until very recently. In ToSC 1/2024, Struck and Weish\"aupl studied generic compositions of Encryption scheme
