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Anaerobic bacteria dominate the human normal microbiota but strikingly little is known about these commensals. Finegoldia magna is a Gram-positive anaerobe found in the skin and at other non-sterile body surfaces, but it is also an opportunistic pathogen. This study describes a novel protein designated FAF (F. magnaAdhesion Factor) and expressed by more than ninety percent of F. magna isolates. Th
From a longitudinal prospective study, 160 women with spontaneous menopause and without steroid medication were followed during the transition from pre- to postmenopause. After 12 years 152 women were still participating in the study. Blood samples were drawn every 6 months until 1 year after the menopause and every 12 months thereafter. Measurements of bone mineral density (BMD) on the forearm we
The rd1 mouse serves as a model for inherited photoreceptor degeneration: retinitis pigmentosa. Microarray techniques were employed to compare the transcriptomes of rd1 and congenic wild-type retinas at postnatal day 11, when degenerative processes have started but most photoreceptors are still present. Of the several genes that were differentially expressed, focus was put on those associated with
We studied leukemic stem cells (LSCs) in a Smad4(-/-) mouse model of acute myelogenous leukemia (AML) induced either by the HOXA9 gene or by the fusion oncogene NUP98-HOXA9. While HOXA9-SMAD4 complexes accumulate in the cytoplasm of normal hematopoietic stem- and progenitor cells (HSPCs) transduced with these oncogenes, there is no cytoplasmic accumulation of HOXA9 in Smad4(-/-) HSPCs and as a con
Ab initio and density functional CCSD(T)-F12/cc-pVQZ-f12//B2PLYPD3/6-311G** calculations have been performed to unravel the reaction mechanism of triplet and singlet methylene CH2 with ketene CH2CO. The computed potential energy diagrams and molecular properties have been then utilized in Rice–Ramsperger–Kassel–Marcus-Master Equation (RRKM-ME) calculations of the reaction rate constants and produc
In Activity Based Working Environment (ABWE) offices, employees are allowed increased autonomy and are expected to choose where, when, with whom, and to some degree with what, to work; in other words, employees are expected to self-lead to a higher degree and to coordinateand align with colleagues. Effectsof these expectations on employees’cogniti
Skogen spelar en viktig roll för den globala biologiska mångfalden, klimatet och är kopplade till urfolks kulturella överlevnad. Samernas traditionella rennäring är beroende av skogens ekosystem. Expansionen av kommersiellt skogsbruk i Sverige har dock lett till betydande konflikter om markanvändning, där samernas rättigheter ofta nedprioriteras till förmån för andra ekonomiska intressen. Denna uForests are vital for global biodiversity, environmental sustainability and are intrinsically linked to the cultural survival of Indigenous peoples. The Sámi traditional reindeer herding practices depend on forest ecosystems. However, the expansion of commercial forestry in Sweden has led to significant conflicts over land use, with the Sámi people’s rights frequently being de-prioritised in favou
Recently, two intracellular isoforms of CD59 were discovered in pancreatic beta cells. They proved crucial for insulin secretion and were named Isoforms Rescuing Insulin Secretion 1 and 2 (IRIS-1 and IRIS-2), whose expression decreased in type 2 diabetes (T2D). IRIS-1 and 2 were found across many different tissues on the mRNA level, including the brain. This Master's Thesis focuses on the role
The aim of this study is to investigate what causes the electoral success of different subtypes of populism through the ideational approach. Through a case study of Spain, the thesis examines the demand-side and supply-side factors that, together, favour the emergence of populist parties. In doing so, the thesis combines process-tracing method with quantitative data, providing a context-specific u
This is a case study examines a possible regime shift between the Kyoto Protocol and the Paris Agreement. The study is using a theory consuming approach, with process tracing as the main instrument of analyzation. Using Keohane & Victor’s theory on regime complex, the two different regimes are highlighted: Kyoto and Paris. Applying Abbot, Green and Keohane’s theory on Organizational Ecology, h
The study aimed to investigate the relationship between the leadership style of future leaders, their personality, as well as their perceived stress level. The Full Range Leadership model with a focus on the transformational leadership dimension, as well as the Five-Factor personality model were used as a theoretical basis. The study was conducted with eighty- seven participants enrolled in a Mast
This study investigates and compares the value added by merger and acquisition activity within the airline industries of the United States of America and Europe following the deregulation of each respective market. An abnormal return event study methodology was performed with three different event window lengths using a final sample of 64 public airline mergers. The focus of the study was on abnor
For decades, entrepreneurs faced the same trade-off: either pursue cost leadership and grow fast through various scaling strategies or pursue differentiation strategies by emphasizing personalization of their services to customers. Nevertheless, the situation has changed when new technologies such as artificial intelligence, rising computing power, digitization of firms, or cloud services started
This thesis explores the changing symbolic meanings of parliamentary buildings in Georgia and Ukraine. It focuses on how these spaces evolved from symbols of Soviet authority to main sites of resistance and political struggle through protest movements. The study offers a comparative analysis of Georgia and Ukraine through six key events that illustrate the symbolic transformation of the parliament
This thesis analyzes the legal challenges of inheritances within Colombia’s tax treaty network, specifically addressing the asymmetrical tax coverage that arises when Colombia applies Double Taxation Conventions on Income and Capital to cross-border inheritances. The core research question is whether inheritance taxes can be covered by the OECD Model Tax Convention on Income and Capital, as interp
This thesis explores the Value Added Tax (VAT) treatment of vouchers within the framework of the EU’s Voucher Directive, with a particular focus on its application to discount vouchers, city cards, and VAT special schemes. The Voucher Directive has been implemented to harmonize and clarify the VAT treatment of vouchers across Member States including distinctions between single-purpose and mult
This research has explored the role actors from various scales have in the production of Research, Innovation and Smart Specialisation Strategies (RIS3) in the Eastern and Southern Netherlands through its multi-level governance framework. This could be worrying, as the influence from higher-scale actors could weaken RIS3’s ability to create place-based programmes. In order to gain an understanding
This essay considers to what extent the process of the 2016 referendum on the United Kingdom’s membership of the EU was democratic. The method by which this study finds its result is a normative method with democratic values in the center of the evaluation. These democratic values are shaped by two theorists, Robert A. Dahl and Stephen Tierney. The democratic values in the center for this evaluati
