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We have briefly discussed herein four of the many aspects that raise concerns in the context of implementation of whole-exome and whole-genome sequencing (mainly) in the clinical realm. Namely, we addressed issues surrounding: (1) the duty to hunt for variants known to have a health impact, (2) such “hunting” or opportunistic screening in children, (3) challenges to the consent process, and (4) th
This chapter seeks to develop a theoretical basis for better understanding the intersections between public diplomacy (PD) and development communication (Devcom). It will be argued that both fields involve (1) theories of influence over social change in foreign countries; (2) a voluntary transfer of resources from an actor promoting a specific cause or agenda to a group or organization in a foreig
Will technical change spur conflicts in the labor market? In this study, we examine electricity adoption in Sweden during the first decades of the twentieth century. Exploiting that proximity to hydropowered plants shaped the electricity network independently of previous local conditions, we estimate the impact of electricity on labor strikes. Our results indicate that electricity adoption precede
Over the past 50 years Umeå has displayed constant growth, making it the fastest-growing region in northern Sweden. It is therefore crucial that Umeå grows with regards to environmental, social, cultural and economic aspects. Sharing City Umeå, which is a test-bed for the sharing economy, is focusing on innovative solutions for shared mobility, green spaces, resource efficiency, sustainable consum
Objectives: ACST-2 is currently the largest trial ever conducted to compare carotid artery stenting (CAS) with carotid endarterectomy (CEA) in patients with severe asymptomatic carotid stenosis requiring revascularization. Methods: Patients are entered into ACST-2 when revascularization is felt to be clearly indicated, when CEA and CAS are both possible, but where there is substantial uncertainty
Glas- och bärnstenspärlor var en del av dräkten som signalerade bärarens sociala och ekonomiska status. I artikeln presenteras pärluppsättningarna från 25 gravar daterade till yngre romersk järnålder period C1 och C2 funna i dagens Skåne. Pärlorna har ett varierat och unikt uttryck vilket stärker hypotesen att de mindre rika gravarna i Skåne, jämfört med på Själland, beror på ett mer stabilt samhäGlass and amber beads are colourful artefacts that have been much less discussed than other accessories such as fibulae. Like these, the beads were part of the dress that signalled the wearers’ social and economic status. In the article, beads from 25 graves from modern-day Scania, dated to the Roman Iron Age periods C1 and C2, are presented. In many ways they show a varied and unique expression,
Basis pursuit (BP), basis pursuit deNoising (BPDN), and least absolute shrinkage and selection operator (LASSO) are popular methods for identifying important predictors in the high-dimensional linear regression model (Formula presented.). By definition, when (Formula presented.), BP uniquely recovers (Formula presented.) when (Formula presented.) and (Formula presented.) implies (Formula presented
We exploit a large historical shock to the Danish labour market to provide evidence of how restrictions on labour mobility increase monopsony power and thereby reduce wages. By severely limiting the possibility of the rural population to work beyond their place of birth, the reintroduction of serfdom in 1733 aimed to increase monopsony power and secure cheaper labour in the countryside. Using a un
Growing evidence suggests a consistent association between atrial fibrillation (AF) and cognitive impairment and dementia that is independent of clinical stroke. This report from the AF-SCREEN International Collaboration summarizes the evidence linking AF to cognitive impairment and dementia. It provides guidance on the investigation and management of dementia in patients with AF on the basis of b
This article examines the emergence of a ‘migration industry’ as a result of European border externalisation and security outsourcing practices to curb migration flows from Libya. It argues that the management of migration has been partly delegated to a network of interlinked private and public actors which constitute a complex migration governance structure that ultimately gives rise to issues of
Organizational scholars have long studied and theorized the apparent divergence of discourse and practice in organizational settings, and how it affects leadership, management, and professional work. In this article, we review this work and connect it to an hitherto unexplored philosophical line of thought from the writings of the late Czech playwright, dissident and president Václav Havel. In 197
The glycyl-tRNA synthetase from Thermus thermophilus is a dimer of molecular mass 115 kDa, which has been crystallised using the vapour diffusion method from 5 to 7% polyethylene glycol 6000, 0.8 to 1.4 M NaCl at protein concentrations of 2 to 8 mg/ml. Nucleation is carried out at 4°C and crystals are subsequently transferred to 15°C to maximise growth. Crystals are truncated rhombohedra measuring
Background and Objectives: Early vascular aging determines a more rapid course of age-related arterial changes. It may be induced by a proinflammatory state, caused by hyperuricemia and metabolic syndrome and their interrelationship. However, the impact of serum uric acid (SUA) on early arterial stiffening and vascular function remains uncertain. Materials and Methods: A total of 696 participants
In this article we present the long-run gains of adopting a nutritious school meal program for Swedish children. During the 1960s, Sweden rolled out a universal program that provided nutritious school lunches free of charge to all children in Swedish primary schools. Our results show that the school lunch program generated substantial long-term benefits, where pupils exposed to the program during
The prevalence and character of political action has changed throughout the Global North, as individuals increasingly turn away from more conventional forms of political participation towards more everyday, continuous types of actions. In this study, I conceptualize one form of everyday political action as a politics of community. A politics of community describes a form of purposeful, collective
The paper presents new geological, geochronological, geochemical, and Nd isotopic data on the late Paleoproterozoic dolerites of the Siberian craton. U-Pb baddeleyite ages of the Doros dolerites (Aldan shield, south-eastern Siberia) and East Anabar dolerites (Anabar shield, northern Siberia) are 1757 ± 4 and 1774 ± 6 Ma, respectively. This new geochronological data together with published 1.76–1.7
The title Diels-Alder reaction gave a mixture of enantiomerically pure adducts with complete norbornane-type monoterpene skeletons. The exo/endo ratio of the products changed from approximately 4:1 at 5° to 2:1 at 165°
