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Parkinson's disease (PD) is a progressive neurodegenerative disorder with a growing global burden. Current pharmacological therapies remain limited to symptomatic management, owning to an incomplete understanding of the mechanisms driving α‑synuclein aggregation and disease progression. This review provides an integrated overview of PD across epidemiological, etiological, pathophysiological, and c
BACKGROUND: An international panel of obesity medicine experts from multiple professional organizations examined patterns of obesity care and current obesity treatment guidelines to identify areas requiring updating in response to emerging science and clinical evidence.AIMS: The panel focused on multiple medical health and societal issues influencing effective treatment of obesity and identified s
This chapter is situated in the intersection between a practice paper and a scienti!c paper. The authors of the chapter are researchers and teachers in teacher education and upper secondary school. All are part of a funded practice-based research project focusing on EDI (electronic digital instrument), within a national pilot project commissioned by the Swedish government from 2017 to 2024, an ini
Fire has shaped terrestrial ecosystems for hundreds of millions of years. Human activities dramatically shift natural fire regimes, leading to adverse conservation impacts that are projected to increase in severity. Many animals appear ill-equipped to face these drastic changes, and they may be unable to adapt rapidly enough. In contrast, behavioural plasticity could offer a faster solution to ach
The GERD has been a focal point of hydropolitical tensions in the Nile River Basin, primarily involving Ethiopia, Sudan, and Egypt. This article examines Sudan’s unique position and role as a potential mediator in this tripartite dispute. Khartoum’s mediation role, driven by its own vested interests in the dam’s operation, including benefits from regulated flood control, electricity generation and
The genus Lupinus (Fabaceae) represents an exceptional model system for studying evolutionary processes mediated by pollinators and environmental factors. This review synthesizes evidence on phenotypic variability of floral traits, trait selection by biotic and abiotic factors, and the eco-evolutionary implications of these interactions. Pollinators shape floral traits through specialized selectio
A tumour grows when the total division (birth) rate of its cells exceeds their total mortality (death) rate. The capability for uncontrolled growth within the host tissue is acquired via the accumulation of driver mutations which enable the tumour to progress through various hallmarks of cancer. We present a mathematical model of the penultimate stage in such a progression. We assume the tumour ha
Music education research in Sweden and across the Nordic countries has investigated questions of cultural diversity in music education for several decades. Greater cultural diversity in music education has also been a longstanding curricular goal. While interest in broadening cultural diversity in music education has been high, the extent to which these aspirations have impacted singing repertoire
This Letter presents measurements of long-range transverse-momentum correlations using a new observable, v0(pT), serving as a probe of event-by-event radial-flow fluctuations, the underlying radial expansion, and the medium's properties in heavy-ion collisions. Results are reported for inclusive charged particles, pions, kaons, and protons across various centrality intervals in Pb-Pb collisions at
BACKGROUND: Accreditation of cancer centres aims to deliver high-quality, person-centered care and underscores the integration with education, research, and innovation. Over the past decade, cancer centres in the Nordic countries have engaged in accreditation processes through the Organisation of European Cancer Institutes (OECI).OBJECTIVE: This study provides an overview of a rapidly evolving lan
Culture and creativity are active but often overlooked processes in contemporary urbanisation. This paper contributes to scholarship on the cultural and creative industries, as well as urban placemaking on the margins, by adopting a placemaking approach in which artists are positioned at the centre of the analysis. The focus is on why artists choose to be located away from national cultural hubs,
Claims have recently been made for a 'mobilities paradigm' which is challenging the relative 'a-mobile' focus of much of the social sciences. The agenda drawn up for this mobilities paradigm is clearly based on Northern trends with little consideration of the South. African populations have always been mobile but little is known about the mobility of urban populations and in particular of the yout
The early Phanerozoic has long been thought to have witnessed a decline in the ocean dissolved silicon inventory, but direct, quantitative investigations of dissolved silicon concentrations are missing. Silicon isotope fractionation by modern siliceous sponges is known to be related to ambient seawater silicon concentrations, opening a potential window onto reconstructions of silicon concentration
This chapter examines the Iranian state-produced film The Golden Collars as a tool of regime propaganda, focusing on how it constructs narratives of heroes and villains within the context of the 2009 post-election protests. It shows how the Islamic Republic, through state media, portrays foreign intelligence services—particularly those of the United States, United Kingdom, and Israel—as orchestrat
Current strategies to reduce the climate impact of production and consumption are insufficient to meet the pressing targets of the Paris Agreement. To expand visions of the possible ‘solution space’ in climate transitions, we explore a framework based on two dichotomies centred around the role of labour and the composition of economic output. From these dichotomies we sketch out four pathways for
As a fluid age cohort and a social category between childhood and adulthood – and hence with tenuous links to the status quo – youth are variously described as ‘at risk’, as victims of precarious and unpredictable circumstances, or as agents of social change who embody the future. From this future-oriented generational perspective, youth are often mobilised to individually and collectively imagine
Background: Standardized definitions of autoimmune disease (AD) are lacking. Therefore, we aim to propose a definition of AD for register-based research and estimate the burden of AD in Sweden as registered in the National Patient Register (NPR) from 1980 to 2023. Methods: Leveraging the NPR, we defined AD as having at least two relevant International Classification of Diseases (ICD) codes represe
This chapter investigates how the challenging questions and tensions caused by migrants and their universalist claims for inclusion, have been approached and resolved in liberal democracies. By regarding the development of populism as a real and dangerous political phenomenon that has significant traction, the chapter asks whether populism adds something new to this approach and resolution. More s
Behavioral, physiological, and life-history adaptations to the lunar cycle are global phenomena across trophic levels and ecosystems yet remain poorly understood because of the challenges of studying free-living organisms at night. We show that the lunar cycle regulates both daily foraging activity and foraging success in the red-necked nightjar-a nocturnal avian insectivore-and that moonless peri
