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Seventy-four addictive alcoholic subjects were investigated shortly after a period of excessive drinking and were compared with 18 alcoholic subjects who had not been drinking for at least six months. No difference was observed in total white cell count or number of circulating granulocytes. Lymphocyte count was significantly lower in alcoholics whose last alcoholic bout had been three months or m

Neurodegenerative disorders (NDDs) such as Huntington's disease (HD) and the spectrum of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are characterized by progressive loss of selectively vulnerable populations of neurons. Although often associated with motor impairments, these NDDs share several commonalities in early symptoms and signs that extend beyond motor dysfunction

The engram encoding the interval between the conditional stimulus (CS) and the unconditional stimulus (US) in eyeblink conditioning resides within a small population of cerebellar Purkinje cells. CSs activate this engram to produce a pause in the spontaneous firing rate of the cell, which times the CS-conditional blink. We developed a Bayesian algorithm that finds pause onsets and offsets in the r

he effect of viscosity on the nasal absorption and biological response to desmopressin was studied in humans. Nasal solutions of desmopressin with and without the addition of 0.25% (w/v) methylcellulose were administered by a precompression nasal spray pump to 10 volunteers. Plasma levels of desmopressin were assayed by radioimmunoassay and the biological response was measured by determination of

Despite the rapidly expanding literature on agency in regional development, the methodological approaches available to study it have not followed theoretical development and empirical studies. This article aims to shed light on methodological issues related to the study of path dependence, path creation and agency. The article’s main purpose is to construct a methodology - path tracing - that woul

This work presents estimates of the emissions resulting from the production of white sugar and its by-products (molasses, pressed beet pulp and dried beet pulp) from sugar beet cultivation to the final product at the factory gate. The study covers the impact of global warming potential, eutrophication potential (freshwater and marine) and particulate matter. The analysis was based on detailed prim

How best to understand the responses of the European Community's member states to the new conditions prevailing in Europe at the end of the Cold War?The book claims that the beliefs behind symbolic agreements provide a greater understanding of European integration than a focus on the material motivations of agreements of substance. It breaks new ground by arguing that intergovernmental cooperation

Huntington’s disease is caused by a mutation in the gene that codes for the protein huntingtin (HTT). A therapeutic strategy for Huntington’s disease is to lower the levels of huntingtin in the brain. However, multiple clinical trials have been stopped due to adverse effects. This indicates that there is still a lot that we do not understand about huntingtin. Similarly to other neurodegenerative d

Context. The Gaia-ESO Survey (GES) is a large public spectroscopic survey that was carried out using the multi-object FLAMES spectrograph at the Very Large Telescope. The survey provides accurate radial velocities, stellar parameters, and elemental abundances for ~115 000 stars in all Milky Way components. Aims. In this paper, we describe the method adopted in the final data release to derive lith

In this article, I challenge the increasing emphasis on digital technologies to enhance encounters with the past in heritage landscapes. Beginning with a memory from my childhood, I conceptualise presence as being there and review recent approaches in heritage studies that highlight the wide range of benefits derived from embodied experiences in heritage places including reinforcing feelings of we

Background: Parkinson's disease (PD) is a progressive neurodegenerative disorder associated with substantial costs which increase with progression state. However, few studies have investigated the association between costs and health related quality of life. Objectives: To estimate the relationship between costs and health related quality of life, measured by the Parkinson's disease Quality of Lif

We report the discovery of a new ultra-short-period planet and summarize the properties of all such planets for which the mass and radius have been measured. The new planet, K2-131b, was discovered in K2 Campaign 10. It has a radius of and orbits a G dwarf with a period of 8.9 hr. Radial velocities obtained with Magellan/PFS and TNG/HARPS-N show evidence for stellar activity along with orbital mot

Farms can harbor substantial biodiversity, which in turn sustains the supply of ecosystem services. The effectiveness of farm management to enhance biodiversity, however, may be modified by land cover in the surrounding landscape beyond a farmer’s direct control. We examined how landscape pattern and farm management affect the abundance and diversity of native bees visiting highbush blueberry in V

Raimo Tuomela’s we-mode groups are partly characterized by norms. Some norms may be characteristic of all we-mode groups, like the norm restricting a member's right to leave the group. Some think that this aspect of Tuomela’s theory has implausible ethical implications concerning the rights and autonomy of members in we-mode groups. That worry vanishes, I argue, on a plausible interpretation of Tu

Purpose of Review: This review evaluates cow milk’s impact on breast carcinogenesis by linking recent epidemiological evidence and new insights into the molecular signaling of milk and its constituents in breast cancer (BCa) pathogenesis. Recent Findings: Recent prospective cohort studies support the association between cow’s milk consumption and the risk of estrogen receptor-α-positive (ER+) BCa.