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This thesis examines why working time preferences differ between workers and nations, and explains the effect of working time regulation and working time flexibility on negotiating work-life balance. In five separate sections the following working time issues are examined: the number of hours worked by workers in Europe; factors affecting individual working time preferences; how working time prefe
Convertible preferred shares are, the most frequently used investment instrument in venture capital or private equity investment. The various rights associated with these shares make them more valuable than ordinary shares. A vital feature, at least for the US venture capitalist, is the conversion right that is the right to convert a preferred share into an ordinary share. For the right of convers
Inhibitors for galectin-1 and -3 were synthesized from thiodigalactoside and lactosamine by derivatization of the galactose C3. Introduction of 4-phenyl-1H-1,2,3-triazol-1-yl substituents at the thiodigalactoside C3 by CuAAC, targeting arginine-arene interactions, increased the affinity to 13 nM but yielded little selectivity. The builder 4-(4-phenoxypheny1)-1H-1,2,3-triazol-1-yl substituent, howe
Exome sequencing studies in complex diseases are challenged by the allelic heterogeneity, large number and modest effect sizes of associated variants on disease risk and the presence of large numbers of neutral variants, even in phenotypically relevant genes. Isolated populations with recent bottlenecks offer advantages for studying rare variants in complex diseases as they have deleterious varian
The developing high-resolution chronostratigraphy of the Cambrian provides an updated age model for various geologic and biotic events that occurred during this critical period of Earth history. Broad, time-specific patterns of lithofacies, such as organic-rich deposits, and biofacies appear to be consistent across all Cambrian paleocontinents. Records of important evolutionary events including fi
Structural features of neurons create challenges for effective production and distribution of essential metabolic energy. We investigated how metabolic energy is distributed between cellular compartments in photoreceptors. In avascular retinas, aerobic production of energy occurs only in mitochondria that are located centrally within the photoreceptor. Our findings indicate that metabolic energy f
The main aim of the study was to explore the extent to which familial hypercholesterolemia (FH) influences the life of the patients affected. The study employed a qualitative analysis of semi-structured interviews with 23 outpatients who were being treated following a diagnosis of heterozygous FH at a tertiary hospital in Göteborg, Sweden. Some interviewees reported concerns related to their medic
Background and aims. Adverse events (AE) leading to discontinuation or dose-reduction of thiopurine therapy (TP) occur in 9-28% of patients with inflammatory bowel disease. 6-Thioguanine (6-TG) has been proposed as an alternative treatment in patients intolerant for azathioprine (AZA), but some concerns have been raised about drug safety. Methods. We evaluated in a prospective manner the tolerance
Ambiguous practices and identities of NGOs have become a source of increasing concern for all involved in development intervention. But apart from pointing at dishonest marketing and unfortunate unintended consequences of donors’ support, how can we understand these ambiguities? Based on an ethnographic study of local Bangladeshi NGOs, the article explores actions and behaviour of grassroots NGO s
The surface speciation of orthophosphate ions on goethite has been studied as a function of pH, time, total phosphate concentration, and ionic medium by means of diffuse reflectance FTIR spectroscopy. The samples were prepared in accordance with a distribution diagram of surface species as calculated from thermodynamic data. In agreement with the thermodynamic model three dominating surface comple
The changes in interface structure and chemical composition of a 99.995% pure nickel/yttria-stabilised zirconia (YSZ) interface were examined after heat treatment at 1000 °C in 97% H2/3% H2O with and without polarisation. Impedance spectroscopy was used for electrochemical characterisation. The results were compared to earlier investigations of a less pure nickel/YSZ interface. The pure interface
The anaphylatoxin C3a is a proinflammatory mediator generated during complement activation. The tight control of C3a receptor (C3aR) expression is crucial for the regulation of anaphylatoxin-mediated effects. Key factors regulating constitutive expression of the C3aR in the mast cell line HMC-1 and receptor induction by dibutyryl-cAMP in monomyeloblastic U937 cells were determined by functional ch
In this paper we prove the local existence of complex-valued harmonic morphisms from any compact semisimple Lie group and their non-compact duals. These include all Riemannian symmetric spaces of types II and IV. We produce a variety of concrete harmonic morphisms from the classical compact simple Lie groups SO(n), SU(n), Sp(n) and globally defined solutions on their non-compact duals SO(n, C)/SO(
Helicobacter pylori (H. pylori), atrophic gastritis, dietary and lifestyle factors have been associated with gastric cancer (GC). These factors have been evaluated in a large case-control study nested in the European Prospective Investigation into Cancer and Nutrition carried out in 9 countries, including the Mediterranean area. Participants, enrolled in 1992-1998, provided life-style and dietary
The application of scattering methods in the study of biological and biomedical problems is a field of research that is currently experiencing fast growth. In particular, neutron reflectometry (NR) is a technique that is becoming progressively more widespread, as indicated by the current commissioning of several new reflectometers worldwide. NR is valuable for the characterization of biomolecules
We have made use of a reporter mouse line in which enhanced green fluorescence protein (GFP) is inserted into the Sox1 locus. We show that the GFP reporter is coexpressed with the Sox1 protein as well as with other known markers for neural stem and progenitor cells, and can be used to identify and isolate these cells by fluorescence-activated cell sorting (FACS) from the developing or adult brain
