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Introduction: Sepsis, a widespread global ailment, involves an exaggerated immune response, leading to hyperinflammation and immunosuppression. Extracellular histones, released during hyperinflammation as part of the defensive response against pathogens, significantly contribute to sepsis pathogenesis, compromising viability of the host’s endothelial cells and contributing to organ failure. Method

Background: Metastatic breast cancer (MBC) is a challenging disease, and despite new therapies, prognosis is still poor for a majority of patients. There is a clinical need for improved prognostication where immuno-oncology markers can provide important information. The aim of this study was to evaluate serum immuno-oncology markers in MBC patients and their respective relevance for prediction of

BACKGROUND: GH therapy in adult patients with GH deficiency (GHD) was approved over 10 yr ago, and the indication has subsequently gained broad acceptance. The HypoCCS surveillance database is a suitable means to examine the evolution of diagnostic patterns since 1996.METHODS: Baseline demographics, reported cause of GHD, and diagnostic tests were available from 5893 GH-treated patients. Trends fo

The nuclear stellar disc (NSD) is a flattened high-density stellar structure that dominates the gravitational field of the Milky Way at Galactocentric radius $30\, {\rm pc}\lesssim R\lesssim 300\, {\rm pc}$. We construct axisymmetric self-consistent equilibrium dynamical models of the NSD in which the distribution function is an analytic function of the action variables. We fit the models to the n

BACKGROUND: The use of percutaneous coronary intervention (PCI) to treat unprotected left main coronary artery disease has expanded rapidly in the past decade. We aimed to describe nationwide trends in clinical practice and outcomes after PCI for left main coronary artery disease. METHODS AND RESULTS: Patients (n=4085) enrolled in the SCAAR (Swedish Coronary Angiography and Angioplasty Registry) a

This paper introduces the ForestValue research project CLICKdesign - delivering fingertip knowledge to enable service life performance specification of wood. The consortium is working on a primary innovation to move from the complex, fragmented and general to the easy-to-use, consolidated and specific by provision of a digital tool for specifiers. Other materials tackle this and provide designers

Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a group of autoimmune diseases with inflammation affecting small blood vessels and includes granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA). In this study, we investigated granulocyte and monocyte subsets in a large cohort of AAV patients with emphasis on disease activity and tendency to relapse. A

This paper presents a joint large eddy simulation and laser diagnostic investigation of premixed turbulent low swirl flames. A lean premixed methane/air mixture, of the equivalence ratio 0.60-0.66, is injected from a 50 mm diameter low swirl burner to a low speed co-flowing air at room temperature and pressure. The level-set G-equation is employed to simulate the inner layer flame front. Flamelet

AIM: To investigate the changes in prevalence and incidence of pharmacologically and non-pharmacologically treated diabetes in Sweden during 2005 to 2013.METHODS: We obtained data on gender, date of birth and pharmacologically and non-pharmacologically treated diabetes from national registers for all Swedish residents.RESULTS: During the study period a total of 240 871 new cases of pharmacological

Background: Gene expression (GEX) signatures in breast cancer provide prognostic information, but little is known about their predictive value for tamoxifen treatment. We examined the tamoxifen-predictive value and prognostic effects of different GEX signatures in premenopausal women with early breast cancer. Methods: RNA from formalin-fixed paraffin-embedded tumor tissue from premenopausal women

BACKGROUND: Perfluoroalkyl substances (PFAS) have been associated with impaired antibody levels after childhood vaccinations and immunosuppressive effects in animals. However, the in vivo effects of PFAS on antigen specific human T cell responses have not been investigated in adults. In Ronneby, Sweden, the drinking water of one of the water works was previously highly contaminated with primarily

Popular Abstract in Swedish Föreliggande avhandling, I litteraturens mittfåra, behandlar bokmarknad, bokklubbar och litteraturen under 1970-talet i Sverige. Bakgrunden till undersökningen är de radikala förändringar som skedde på den svensk bokmarknaden efter den genomgripande avregleringen av handeln med böcker 1970. Bokklubbarna växte från att inneha en marknadsandel på 9% 1970 till att ha 30% aThe present dissertation, I litteraturens mittfåra, deals with book trade, book clubs, and the fiction prose of the 1970s in Sweden. The background to the study is the radical change in Swedish book trade through a far-reaching deregulation of the trade in 1970. The book clubs expanded from a position where they held a 9% share of the market in 1970 to a market share of 30% in 1980.And the specifi

Under electrochemical polarization, many electrocatalysts can undergo oxidation that alters their reactivity and can lead to restructuring and dissolution. In this context, the structure-property relationships of electrocatalysts, as well as their kinetics and dynamic behaviour, are still poorly understood. This knowledge gap mainly relies on the limitations of many traditional spectroscopic and s

delta C-13 values of numerous limestone samples from Katian (Upper Ordovician) successions in Oklahoma and the Upper Mississippi Valley document the presence of at least three of the four positive excursions that have been recognized in the lower-middle Katian interval in the Cincinnati region in Ohio. Kentucky, and Indiana. A comparison with Estonia reveals that five out of the six positive excur

Mucosal tissues contain large numbers of memory CD4(+) T cells that, through T-cell receptor-dependent interactions with antigen-presenting cells, are believed to have a key role in barrier defense and maintenance of tissue integrity. Here we identify a major subset of memory CD4(+) T cells at barrier surfaces that coexpress interleukin-18 receptor alpha (IL-18Rα) and death receptor-3 (DR3), and d