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Classic Thrombophilias and Thrombotic Risk Among Middle-Aged and Older Adults : A Population-Based Cohort Study

BACKGROUND: Five classic thrombophilias have been recognized: factor V Leiden (rs6025), the prothrombin G20210A variant (rs1799963), and protein C, protein S, and antithrombin deficiencies. This study aimed to determine the thrombotic risk of classic thrombophilias in a cohort of middle-aged and older adults. METHODS AND RESULTS: Factor V Leiden, prothrombin G20210A and protein-coding variants in

Early life exposure to mercury and relationships with telomere length and mitochondrial DNA content in European children

Background: Telomere length (TL) and mitochondrial function expressed as mitochondrial DNA copy number (mtDNAcn) are biomarkers of aging and oxidative stress and inflammation, respectively. Methylmercury (MeHg), a common pollutant in fish, induces oxidative stress. We hypothesized that elevated oxidative stress from exposure to MeHg decreases mtDNAcn and shortens TL. Methods: Study participants ar

Abbreviated versus standard dual antiplatelet therapy times after percutaneous coronary intervention in patients with high bleeding risk with acute coronary syndrome : Insights from the swedeheart registry

BACKGROUND: Dual antiplatelet therapy (DAPT) reduces ischemic events but increases bleeding risk, especially in patients with high bleeding risk (HBR). This study aimed to compare outcomes of abbreviated versus standard DAPT strategies in patients with HBR with acute coronary syndrome undergoing percutaneous coronary intervention. METHODS AND RESULTS: Patients from the SWEDEHEART (Swedish Web-syst

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LUNDS UNIVERSITY Department of Archaeology and Ancient History Reading list - ARKN07, The Archaeology of Social Identities, 15 hp Established by the Board of Department: 2011-11-08 Alberti, B. 2006. Archaeology, Men, and Masculinities. I: Nelson, M. S. (red.) Handbook of Gender in Archaeology. New York, Toronto, Oxford. p. 401-434. 33 p. Axboe, M. 1999. Towards the Kingdom of Denmark. I: Dickinson

https://www.ark.lu.se/media/utbildning/dokument/kurser/ARKN07/20132/Readning_list_ARKN07_2.pdf - 2026-05-19

Measured capacity gain using waterfilling in frequency selective MIMO channels

We analyze the channel capacity of multiple-input multiple-output (MIMO) systems in frequcncy selective channels, with channel knowledge at the transmitter side. An optimum transmission scheme uses Shannon's principle of waterfilling jointly in the frequency and the spatial domain. However, we show in this paper that the largest gain by using waterfilling resides in the spatial domain, and that th

Indigenous enteric eosinophils control DCs to initiate a primary Th2 immune response in vivo.

Eosinophils natively inhabit the small intestine, but a functional role for them there has remained elusive. Here, we show that eosinophil-deficient mice were protected from induction of Th2-mediated peanut food allergy and anaphylaxis, and Th2 priming was restored by reconstitution with il4(+/+) or il4(-/-) eosinophils. Eosinophils controlled CD103(+) dendritic cell (DC) activation and migration

Words and their meaning: a deep delve from surface distribution into underlying neural representation

This special issue of The Mental Lexicon contains a number of papers presented at a symposium at the Center for Languages and Literature, Lund University, on December 10, 2009. The interdisciplinary meeting brought together researchers from linguistics, psychology, and neuroscience in order to discuss different approaches to studying the complexities surrounding the modelling of word semantics.

TERT promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal

Malignant cells, like all actively growing cells, must maintain their telomeres, but genetic mechanisms responsible for telomere maintenance in tumors have only recently been discovered. In particular, mutations of the telomere binding proteins alpha thalassemia/mental retardation syndrome X-linked (ATRX) or death-domain associated protein (DAXX) have been shown to underlie a telomere maintenance

Features associated with germline CDKN2A mutations: a GenoMEL study of melanoma-prone families from three continents

BACKGROUND: The major factors individually reported to be associated with an increased frequency of CDKN2A mutations are increased number of patients with melanoma in a family, early age at melanoma diagnosis, and family members with multiple primary melanomas (MPM) or pancreatic cancer. METHODS: These four features were examined in 385 families with > or =3 patients with melanoma pooled by 17 Gen

A palaeolimnological study of the anthropogenic impact on dissolved organic carbon in South Swedish lakes

Popular Abstract in Swedish De senaste ca trettio åren har man observerat en kraftig ökning av löst organiskt kol i sjöar, vattendrag och kustnära vatten i olika delar av det norra halvklotet, bl.a. i delar av Nordamerika, Storbritannien, Baltikum, centrala Europa och Skandinavien. I Sverige har ökningen främst varit koncentrerad till de södra delarna av landet. Löst organiskt kol i sjöar belägna During the past three decades, increases have been observed in dissolved organic carbon (DOC) concentrations and colour in the surface waters of lakes and rivers in parts of Europe and North America, raising concern about the effects on the quality of aquatic environments with consequences for biodiversity, resource availability and recreational use. Various hypotheses have been put forward to exp

Microfluidic biosensing systems based on enzymes, antibodies and cells

Popular Abstract in Swedish Kemister kallas de, som förstå att utreda hwad hwarje sak består utaf, och huru man af beståndsdelarne må kunna sammansätta nya ämnen. Kunskapen härom kallas Kemi. Den största Kemisten war wår landsman Jacob Berzelius, som föddes 1779 i Wäfwersunda i Östergötland och dog i Stockholm 1848. Så skriver N. J. Berlin i sin Läsebok i Naturläran för Sweriges AllmogeThe rapid developments within the life science and biotechnology areas put up ever-new demands on more sophisticated techniques and methods for chemical and biological analysis to reach deeper insight into the events at molecular level. Miniaturisation of assays and systems on microchips is one way to increase throughput and advance through parallel analysis lines, multiplexing and integration. Th

Prophylactic quadrivalent human papillomavirus (types 6, 11, 16, and 18) L1 virus-like particle vaccine in young women: a randomised double-blind placebo-controlled multicentre phase II efficacy trial

Background A randomised double-blind placebo-controlled phase II study was done to assess the efficacy of a prophylactic quadrivalent vaccine targeting the human papillomavirus (HPV) types associated with 70% of cervical cancers (types 16 and 18) and with 90% of genital warts (types 6 and 11). Methods 277 young women (mean age 20.2 years [SD 1.7]) were randomly assigned to quadrivalent HPV (20 μ g

New antimicrobial cystatin C-based peptide active against gram-positive bacterial pathogens, including methicillin-resistant Staphylococcus aureus and multiresistant coagulase-negative staphylococci

We describe the synthesis and antibacterial properties of a novel antimicrobial peptidyl derivative, (2S)-2-(Nalpha-benzyloxycarbonyl-arginyl-leucylamido-1-[(E)-cinnamoylamido]-3-methylbutane, structurally based upon the inhibitory centre of the human cysteine protease inhibitor, cystatin C. The derivative, here called Cystapep 1, displayed antibacterial activity against several clinically importa

Neutrophil-derived proteinase 3 induces kallikrein-independent release of a novel vasoactive kinin.

The kinin-forming pathway is activated on endothelial cells and neutrophils when high-molecular weight kininogen (HK) is cleaved by plasma kallikrein liberating bradykinin, a potent mediator of inflammation. Kinins are released during inflammatory conditions such as vasculitis, associated with neutrophil influx around blood vessels. Some patients with vasculitis have elevated plasma levels of neut

State of the Art and Prospects for Halide Perovskite Nanocrystals

Metal-halide perovskites have rapidly emerged as one of the most promising materials of the 21st century, with many exciting properties and great potential for a broad range of applications, from photovoltaics to optoelectronics and photocatalysis. The ease with which metal-halide perovskites can be synthesized in the form of brightly luminescent colloidal nanocrystals, as well as their tunable an

Relating MR relaxation times of ex vivo meniscus to tissue degeneration through comparison with histopathology

Background: Quantitative magnetic resonance imaging (MRI), e.g. relaxation parameter mapping, may be sensitive to structural and compositional tissue changes, and could potentially be used to non-invasively detect and monitor early meniscus degeneration related to knee osteoarthritis. Objective: To investigate MR relaxation times as potential biomarkers for meniscus degeneration through comparison

Google search trends for itch in Europe : a retrospective longitudinal study

BACKGROUND: Itch is a common symptom in the general population. Affected individuals often do not seek medical consultation and rely on Internet searches to obtain information regarding their itch.OBJECTIVES: The aim of this study was to attain insights into common concerns of the general population regarding itch can by analysing itch-related Internet search behaviour.METHODS: Google AdWords Keyw

Common Carotid Intima-Media Thickness Measurements in Cardiovascular Risk Prediction A Meta-analysis

Context The evidence that measurement of the common carotid intima-media thickness (CIMT) improves the risk scores in prediction of the absolute risk of cardiovascular events is inconsistent. Objective To determine whether common CIMT has added value in 10-year risk prediction of first-time myocardial infarctions or strokes, above that of the Framingham Risk Score. Data Sources Relevant studies we

β-Cell Function and Glucose Tolerance in Persons With Multiple Islet Autoantibodies Randomized to a Gluten-free Diet

PURPOSE: A randomized clinical trial was conducted to evaluate the impact of a gluten-free diet (GFD) on β-cell function and glucose tolerance in persons with multiple islet autoantibodies.METHODS: Individuals (n = 59; median age 11 years) with multiple islet autoantibodies were recruited to a randomized clinical trial between April 2016 and April 2021. The participants were randomized to a GFD (n