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Synovial sarcoma (SyS) is an aggressive soft-tissue malignancy that is characterised by a pathognomonic t(X;18)(p11.2;q11.2) translocation, which produces the fusion oncogene named SS18::SSX. Despite recent advancements in our understanding of synovial sarcoma biology, the cell-of-origin remains undefined. A mesenchymal stromal cell (MSC) specific CreERT2 line was employed to express SS18::SSX in
To generate the required antiproton beam intensity for the FAIR PANDA experiment, a dedicated proton LINAC (pLINAC) for the FAIR accelerator chain is being constructed. Klystron modulators are power converters within the high-power RF system of the pLINAC. Here, seven modulator systems with a nominal pulse power amplitude of 115 kV / 54 A, an effective pulse width of 360 µs and a pulse repetition
Electrostatic energy plays a pivotal role in the minimization of the free energy of self-assembling oppositely charged ions. This is a fundamental principle that guides the formation of aggregates and the separation of phases characterized by a stoichiometric balance between the opposite charges. However, this study unveils the self-assembly of catanionic nanotubes from a mixture of oppositely cha
The capacity for birds to adjust their breeding time to variation in spring temperature via plasticity is crucial for insectivorous passerines in temperate areas, particularly in a context of climate disruptions. Recent studies suggested that phenological plasticity varies in response to environmental change via urbanization. We investigated the effects of urbanization on laying date, its phenotyp
Creative Data Lab (CDL), hosted as an Advanced Study Group at the Pufendorf Institute for Advanced Studies, Lund University, brought together artist-researchers and research support staff to explore artistic research data management (ARDM) in relation to documentation, storage, sharing, and use. Working across disciplines and in dialogue with national and international debates, the group examined
BACKGROUND Valid and reliable assessment of skills is essential for improved and evidence-based training concepts. In a recent study, we presented a novel tool to assess procedural skills in resuscitative endovascular balloon occlusion of the aorta (REBOA), REBOA-RATE, based on international expert consensus. Although expert consensus is a strong foundation, the performance of REBOA-RATE has not b
Becoming a father, especially for the first time, can present changes in men's identity and in the relationship with their partner. Affinity within the family and participation in the whole process of pregnancy, childbirth and the postnatal period are important for fathers' sense of postnatal security. The fathers want to be already prepared before birth for the early postnatal period. Willingness
In recent years, street art has become embedded in popular culture and received growing attention from the art market and art institutions. Work by street artists has entered galleries, auction houses and museums, and some artists have been given the opportunity to create large-scale sanctioned public art projects. Simultaneously, widespread photographic documentation of street artworks and the ci
Many patients with asthma or chronic obstructive pulmonary disease (COPD) routinely receive a combination of an inhaled bronchodilator and anti-inflammatory glucocorticosteroid, but those with severe disease often respond poorly to these classes of drug. We assessed the efficacy and safety of a novel inhaled dual phosphodiesterase 3 (PDE3) and PDE4 inhibitor, RPL554 for its ability to act as a bro
A major barrier for cancer immunotherapy is the presence of suppressive cell populations in patients with cancer, such as myeloid-derived suppressor cells (MDSC) and tumor-associated macrophages (TAM), which contribute to the immunosuppressive microenvironment that promotes tumor growth and metastasis. Tasquinimod is a novel antitumor agent that is currently at an advanced stage of clinical develo
Abstract in UndeterminedThis article points to four worrisome aspects of the Court’s reasoning in Rantsev v. Cyprus and Russia. First, the Court takes on board the concept of ‘human trafficking’ without offering any meaningful legal analysis as to the elements of the human trafficking definition. Second, the adoption of the human trafficking framework implicates the ECtHR in anti-immigration and a
Collagen-induced arthritis (CIA) is a T cell-dependent autoimmune disease that serves as an animal model for human rheumatoid arthritis. CIA can be induced in H-2q mice by a single immunization with the cartilage-specific protein type II collagen (CII). This study has focused on CII immunity and tolerance with respect to the interactions between antigen, antigen-presenting cells and T cells. CIA-r
In agriculture, as in industry, have many physically demanding jobs disappeared and the physical stress factors have changed. However, the working days in farms are often long, and it is difficult to hire workers for help as the work conditions are considered to be harsh. The thermal work environment in farms is one of the factors influencing the work conditions. This study aimed to find out the p
We present a study of a novel variant of the Self-Organizing Map (SOM) called the Associative Self-Organizing Map (A-SOM). The A-SOM is similar to the SOM and thus develops a representation of its input space, but in addition it also learns to associate its activity with the activity of one or several external SOMs. The A-SOM has relevance in e.g. the modelling of expectations in one modality due
Pathogenic fungi represent a major threat particularly to immunocompromised hosts, leading to severe, and often lethal, systemic opportunistic infections. Although the impaired immune status of the host is clearly the most important factor leading to disease, virulence factors of the fungus also play a role. Factor H (FH) and its splice product FHL-1 represent the major fluid phase inhibitors of t
