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Recent reports focusing on virulence factors of periodontal pathogens implicated proteinases as major determinants of remarkable pathogenicity of these species, with special emphasis on their capacity to modulate complement activity. In particular, bacteria-mediated cleavage of C5 and subsequent release of C5a seems to be an important phenomenon in the manipulation of the local inflammatory respon

Polyethyleneimine (PEI) is an organic polycation used extensively as a gene- and DNA vaccine delivery reagent. Although the DNA targeting activity of PEI is well documented, its immune activating activity is not. We recently reported that PEI has robust mucosal adjuvanticity when administered intranasally with glycoprotein antigens. Here we show that PEI has strong immune activating activity after

We study the chemical abundances of the strontium filament found in the ejecta of eta Carinae. In particular, we derive the abundances of iron-peak elements from the spectra of their singly ionized ions present in the optical/infrared (IR) spectra. In this paper we analyse the spectrum of Mn II using a new non-local thermodynamic equilibrium (non-LTE) model for this system. In constructing this mo

Three species of Caloplaca are described as new to science: Caloplaca caesiosorediata Arup & van den Boom, a corticolous species and two saxicolous species, Caloplaca catillarioides Arup & van den Boom, and C. caesioisidiata Arup & van den Boom, all from the archipelago of Cape Verde. They are dark-fruited and have a pale to dark greyish crustose thallus. None of the new species are ph

CK2, an acronym derived from the misnomer "casein kinase 2", denotes a ubiquitous and extremely pleiotropic Ser/Thr protein kinase, the holoenzyme of which is composed of two catalytic (alpha and/or alpha') and two noncatalytic beta subunits acting as a docking platform and the multifarious functions of which are still incompletely understood. By combining affinity chromatography and mass spectrom

BACKGROUND. Androgen deprivation is the only effective systemic therapy available for patients with prostatic carcinoma, but is associated with a gradual transition to a hormone-refractory prostate cancer (HRCAP) in which ligand-independent activation of the androgen receptor has been implicated. The beta(2)-adrenergic receptor (beta(2)-AR) is a well-known activator of the androgen receptor. METHO

Parity forbidden radiative transitions from metastable levels are observed in spectra of low-density astrophysical plasmas. These lines are used as probes of the physical conditions, made possible due to the long lifetime of their upper level. In a joint effort, the FERRUM project aims to obtain new and accurate atomic data for the iron-group elements, and part of this project concerns forbidden l

In this study we establish the use of optical non-contact profilometry combined with low vacuum scanning electron microscopy (LV SEM) for the investigation of lipid surfaces. We illustrate, by using profilometry, a methodology for investigation of chocolate surface topology as a function of time, in the same area of interest. Both qualitative and quantitative data analysis has been performed for p

Objectives We tested the hypothesis that serum total testosterone and sex hormone-binding globulin (SHBG) levels predict cardiovascular (CV) events in community-dwelling elderly men. Background Low serum testosterone is associated with increased adiposity, an adverse metabolic risk profile, and atherosclerosis. However, few prospective studies have demonstrated a protective link between endogenous

Targeted proteomics allows researchers to study proteins of interest without being drowned in data from other, less interesting proteins or from redundant or uninformative peptides. While the technique is mostly used for smaller, focused studies, there are several reasons to conduct larger targeted experiments. Automated, highly robust software becomes more important in such experiments. In additi

The paper explores the implementation process of an innovation measuring system prototype to support a heavy machinery multinational company to secure their innovative capability. In general, companies recognize the importance of becoming innovative to become, or remain, competitive on a global market. The case company decided to pilot a metric system that corresponds to the crucial factors to sec

The following report provides an overview of the discussions and outcome of the EuPA General Council meeting that took place in Estoril 20-21 October 2010. During the annual meeting future policy and action plans in a variety of areas are decided. Several important points were decided upon during this meeting including the expansion of the EuPA Executive Committee by introducing a new EuPA committ

We present detailed chemical element abundance ratios of 17 elements with eight <= Z <= 60 in three metal-poor stars in the Ursa Minor dwarf spheroidal galaxy, which we combine with extant data from the literature to assess the predictions of a novel suite of galaxy chemical evolution models. The spectroscopic data were obtained with the Keck/High-Resolution Echelle Spectrograph instrument and rev