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Few germline mutations are known to affect lung cancer risk. We performed analyses of rare variants from 39,146 individuals of European ancestry and investigated gene expression levels in 7,773 samples. We find a large-effect association with an ATM L2307F (rs56009889) mutation in adenocarcinoma for discovery (adjusted Odds Ratio = 8.82, P = 1.18 × 10−15) and replication (adjusted OR = 2.93, P = 2
The master regulator of neuroendocrine differentiation, achaete-scute complex homolog 1 (ASCL1) defines a subgroup of lung adenocarcinoma. However, the mechanistic role of ASCL1 in lung tumorigenesis and its relation to the immune microenvironment is principally unknown. Here, the immune landscape of ASCL1-positive lung adenocarcinomas was characterized by immunohistochemistry. Furthermore, ASCL1
During the last years, numerous research projects focussed on re-examination of past excavations, giving birth to re-evaluation of their documentation and material or to new discoveries. The aim of this paper is to present an ongoing research on the digital re-assessment of the Ayia Irini sanctuary’s stratigraphy using 3D GIS, by corroborating published material with data extracted from the origin
BACKGROUND: The incidence of cutaneous malignant melanoma (CMM) and melanoma in situ (MIS) has been increasing during the last 50 years. Malignant melanoma (MM) is also the most common intraocular malignancy (IMM). Besides ultraviolet radiation, the cause of these tumours is largely unknown.OBJECTIVES: We designed a study to examine the effect of body mass index (BMI) and tobacco use on the risk f
The educational opportunities of refugee learners are shaped by forces of globalization, restrictive mobility regimes and geopolitical agendas, that place them in a position of structural disadvantage. The majority of the world's refugee learners have fled due to armed conflict and reside in neighboring countries in the global South. In many cases forced displacement is protracted, with limited gl
Attosecond pulses in the extreme ultraviolet (XUV) spectral range are today routinely generated via high-order harmonic generation (HHG), when intense ultrashort laser pulses are focused into a gaseous generation medium. The effect is most easily understood in a semi-classical picture [1]. An electron can tunnel ionize from the distorted atomic potential, pick up kinetic energy in the laser field,
Existing bridges were designed to satisfy old specifications, and most of them were based on a member-oriented approach. A bridge superstructure is constituted by a group of elements that together form a system, and depending on how robust the system is, a member-oriented approach losses accuracy. Therefore, in this study a preliminary framework of how to assess concrete bridges' robustness is pre
Ambulance travel time estimations play a pivotal role in ensuring timely and efficient emergency medical care by predicting the duration for an ambulance to reach a specific location. Overlooking factors such as local traffic situations, day of the week, hour of the day, or the weather may create a risk of inaccurately estimating the ambulance travel times, which might lead to delayed emergency re
In a seminar room at LUX, one of the buildings of the Joint Faculties of Humanities and Theology, a group of PhD students and senior scholars are in deep concentration in front of their computers. It is pin-drop silent in the room until the alarm goes off and everyone starts moving and talking. This is the writing group, an informal and voluntary way of working together in time slots with 45 minut
Bacterial or viral antigens can contain subdominant protein regions that elicit weak antibody responses upon vaccination or infection although there is accumulating evidence that antibody responses against subdominant regions can enhance the protective immune response. One proposed mechanism for subdominant protein regions is binding of host proteins that prevent antibody production against epitop
BACKGROUND: The NOCTET (NOrdic Certican Trial in HEart and lung Transplantation) trial demonstrated that everolimus improves renal function in maintenance thoracic transplant (FIX) recipients. Nevertheless, introduction of everolimus is not recommended for patients with advanced renal failure. We evaluated NOCTET data to assess everolimus introduction amongst TTx recipients with advanced renal fai
Popular Abstract in Swedish Ämnet för denna tematiska och berättartekniska studie i litteraturvetenskap är C. J. L. Almqvists slottskrönika och det indirekta skrivsättet. Slottskrönikan omfattar romanerna Jaktslottet (1833), Hinden (1833) och Baron Julius K*. Ur Fröken Eleonoras Reseminnen (1835), vilka belyses med hjälp av Almqvists uppsats Om två slags Skrifsätt (1833). Denna infogades senare i The subject of this thematic and narrative-technical study is the Swedish author Carl Jonas Love Almqvist's (1793-1866) slottskrönika (castle chronicle) and the indirect way of writing. The castle chronicle comprises the novels Jaktslottet (The Hunting Castle; 1833), Hinden (The Hind; 1833) and Baron Julius K* (1835), all of which are included in Almqvist's great collective work, Törnrosens bok (T
The objective of this research was to examine the effects of chemical compounds with possible P2 receptor modulating effects and to characterize the potentiating effects of 2,2'-nitrophenylisatogen (NPI) on P2X(1) receptors in vitro and in vivo. Chemical compounds were tested in an in vitro pharmacological assay using vascular segments from the rat mesenteric artery stimulated by P2 receptor-speci
Electron emission, in resonance with soft X-ray absorption, appears to provide a measure of the dispersion of the highest occupied and the lowest, core-hole distorted, unoccupied pi-bands in poly(p-phenylenevinylene).
This study examines the motif of the Fallen World in Coleridge’s major poems The Ancient Mariner, Christabel and Kubla Khan . The use of Milton’s Paradise Lost as an intertextual foil throughout allows themes and metaphors inherent in the Fallen World motif to emerge in Coleridge’s poetry. A Fall presupposes a standard from which one has been separated downwards. Primarily, it is understood as man
Popular Abstract in Swedish Varför skulle det vara mer europeiskt att rösta ja till Euron än vad det är att rösta nej? Varför går det inte att vara både populist och ?god europé? på samma gång? Vad skiljer en illegal invandrare från en vanlig turist? På vilka sätt avviker Europa från andra föreställda gemenskaper som exempelvis nationen? Avhandlingen ?bringing europe down to earth? (ung. ta ner euWhy is it considered more European to vote in the affirmative of the Euro than it is to vote against it? Why is not possible to be a populist and a ?Good European? at the same time? What makes an illegal immigrant different from a tourist? These questions all concern the limits of what it means to be, act and think as Europeans in Europe. In the political process of bringing the nations and people
This project was recently carried out as a part of The Swedish Pompeii Project, which was started in 2000 as a research and fieldwork activity initiated by the Swedish Institute in Rome. The aim was to record and analyze an entire Pompeian city block, Insula V 1. Since autumn 2011 a new branch of advanced digital archaeology, involving 3D reconstructions and documentation methods, was added to the
