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Inflammasomes are large multiprotein complexes that assemble mainly in innate immune cells after detection of microbial or sterile insults. Activation of inflammasomes is a key proinflammatory event during infection, and many pathogens have evolved specific evasion mechanisms to evade or inhibit inflammasome activation. One such pathogen is the common bacterium group A Streptococcus (GAS), which c

To investigate aging effect on the passive film of Ni23Cr15Mo and Ni22Cr9Mo3Nb, synchrotron-based X-ray photoelectron spectroscopy (XPS) was used to analyze the structure and composition of the air-formed passive film on the alloys. The corrosion resistance of the two Ni alloys in 1 M NaCl solution was evaluated with electrochemical cyclic polarization measurement. The synchrotron XPS measurement

Inflammatory responses to acute stimuli are proposed to regulate sleep, but the relationship between chronic inflammation and habitual sleep duration is elusive. Here, we study this relation using genetically predicted level of chronic inflammation, indexed by CRP and IL6 signaling, and self-reported sleep duration. By Mendelian randomization analysis, we show that elevated CRP level within <10 mg

The Haro 11 galaxy merger is the closest known Lyman continuum (LyC) leaker and a strong Lyman-α (Lyα) emitter, making it an important analogue of the high-z galaxies that reionised the early Universe. To investigate how Haro 11’s properties arise, we perform a radiation hydrodynamics simulation of the merger, and create mock observations of LyC, Lyα, and Hα, from which we compute their luminositi

This chapter explores the intricate dynamics of transnational Shia networks and their relationship with Iran, focusing on the latter's aspiration to dominate global Shiism and the resistance it faces. It analyzes the transnational character of Shia clerical networks, which have been pivotal in political and communal mobilization since the 1950s, particularly in Iraq. Post-1979, Iran leveraged thes

INTRODUCTION: 360-degree evaluations are used as an assessment in order to identify strengths and weaknesses of, or as a continuous evaluation for, residents. The aim of this study was to investigate the relationship between personality and ratings on 360-degree evaluations among surgical residency applicants. A secondary aim was to describe the personality profile of applicants for a surgical res

This study deals with segmental articulations based on acceleration signals from EMA data. We test how well the one-to-one relationship between acceleration peaks and segment boundaries (as described within the framework of the Descriptive Approach to Segmental Articulations) works across different prosodic levels in Swedish, here: focused and unfocused position, with the assumption of a positive

Most migratory birds return every year to the same breeding sites and some species show a similarly high fidelity to wintering grounds as well. Fidelity to stopover sites during migration has been much less studied and is usually found to be lower. Here, we investigate site fidelity and distance to previously visited sites throughout the annual cycle in the common cuckoo, a nocturnal trans-Saharan

Building as many houses as possible in a factory environment seems like an effective way to systematically reduce productivity costs and improve quality in the building process. Based on this idea, a Swedish company has manufactured modules consisting of one or several rooms that were transported and assembled into multi family dwellings onsite. This paper analyses different improvements regarding

Chancroid caused by Haemophilus ducreyi has been described as a significantly predisposing factor of HIV heterosexual transmission in an endemic region of both diseases. The fastidious, H. ducreyi has been reported world wide with various antimicrobial susceptibility patterns. A high tendency of drug resistances has generally been found among isolates derived in Thailand. In this study, the plasmi

Abstract in UndeterminedIntestinal epithelial cells (IECs) play a key role in Crohn's disease, a chronic inflammatory bowel disease which requires invasive examinations to be diagnosed. The comparison of the cellular protein expression profiles of Crohn's disease patients and healthy subjects is fundamental for the identification of proteins clinically relevant as new biomarkers or as drug targets

BACKGROUND. Recently, the gene for cysteine-rich secretory protein 3 (CRISP-3) was reported to be highly upregulated in prostate cancer (PCa) compared to benign prostatic tissue. The current aims were to investigate diagnostic use of tissue expression and immunodetection in serum of CRISP-3 for detection or monitoring of PCa. METHODS. Radical prostatectomy specimens and tissue microarrays from tra

Tapasin (Tpn) is an ER chaperone that is uniquely dedicated to MHC-I biosynthesis. It binds MHC-I molecules, integrates them into peptide-loading complexes, and exerts quality control of the bound peptides; only when an "optimal peptide" is bound will the MHC-I be released and exported to the cell surface for presentation to T cells. The exact mechanisms of Tpn quality control and the criteria for

The Torrabaai-Koigabmond Complex (southern Kaoko Belt, Namibia) consists of three main intrusive rock types including metaluminous hornblende- and titanite-bearing quartz diorites, metaluminous hornblende- and biotite-bearing granodiorites and peraluminous garnet- and muscovite-bearing leucogranites. Uranium-Pb zircon data obtained on the granodiorites and leucogranites indicate concordia upper in

It has been suggested that the occurrence rate of hot Jupiters (HJs) in open clusters might reach several per cent, significantly higher than that of the field (~a per cent). In a stellar cluster, when a planetary system scatters with a stellar binary, it may acquire a companion star, which may excite large-amplitude von Zeipel-Lidov-Kozai oscillations in the planet's orbital eccentricity, trigger

Object shift (OS) is a word order phenomenon in Scandinavian languages where under some circumstances the object appears before a sentential adverb. Despite the frequent assumptions that word order is determined in syntax, and despite the link of OS and syntactic phenomena like V2, there is no consensus that OS is a syntactic phenomenon. Particularly, it has been observed that OS targets specifica

Chronic glomerular and tubular nephrotoxicity has been reported in up to 50% and 25%, respectively, of children and adolescents treated with ifosfamide and up to 60% and 30% of those given cisplatin. Up to 35% of children have proteinuria and microalbuminuria, implying chronic glomerular damage, after unilateral nephrectomy for a renal tumour. We are still learning about nephrotoxicity due to the