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Background: The Second Primary Angioplasty in Myocardial Infarction (PAMI-II) risk score is recommended by guidelines to identify low-risk patients with ST-elevation myocardial infarction (STEMI) for an early discharge strategy. Aims: We aimed to assess the safety of early discharge (≤2 days) for low-risk STEMI patients treated with primary percutaneous coronary intervention (PCI). Methods: Using
HIV infection affects the course of tuberculosis (TB), and HIV and Mycobacterium tuberculosis (Mtb) synergize in disease progression through complex immunological interplay. To gain further understanding of these mechanisms, we compared the microRNA (miRNA) and small nucleolar RNA (snoRNA) expression patterns in whole blood of individuals with active TB, with and without HIV coinfection (HIV+/TB+
Introduction: This study examined the prevalence of and risk factors for a prolonged passive second stage of labor in nulliparous women. Material and Methods: This was a historical cohort study of all nulliparous women (n = 1131) at two delivery units in Sweden. Maternal and obstetric data were obtained from electronic medical records during 2019. Duration of the passive second stage was measured
INTRODUCTION: Depression is common, increasing among adolescents and carries risk of disability, lower educational achievements, cardiovascular disease, substance abuse, self-harm and suicide. The effects of evidence-based treatments with medication or psychotherapy are modest. Aerobic exercise is a promising intervention for adolescents with depression, but available studies are hampered by metho
The tissue distribution and prognostic relevance of subtype-specific proteins (ASCL1, NEUROD1, POU2F3, YAP1) present an evolving area of research in small-cell lung cancer (SCLC). The expression of subtype-specific transcription factors and P53 and RB1 proteins were measured by immunohistochemistry (IHC) in 386 surgically resected SCLC samples. Correlations between subtype-specific proteins and in
BACKGROUND: Endolichenic fungi are microbes that inhabit the thalli of lichens and produce various unique chemicals that can be used for pharmaceutical purposes.PURPOSE: This study screened a library of endolichenic fungal extracts to identify novel anticancer agents capable of suppressing the tumorigenicity of human cancer cells.METHODS: Active compounds were isolated from extracts of endolicheni
Background: The aim of this study was to systematically review the literature and to perform meta-analyses on full-field electroretinography (ffERG) between healthy controls and age-related macular degeneration (AMD) to map the extent of retinal dysfunction. Summary: We systematically searched 11 databases on 3 March 2021. Eligible studies had to measure retinal function using ffERG in eyes with A
There is a need of problematizing taken for granted assumptions in the conceptualization of collaborative housing when attempting to link collaborative housing and social integration. What are the difficulties and opportunities that migrants and non-migrants face in accessing collaborative housing projects? Addressing such type of questions will help to capture exclusionary processes affecting old
Objective To compare experiences of the second stage of labour in women randomised to assistance by one or by two midwives to reduce severe perineal trauma (SPT). Design Analysis of a secondary outcome within the Swedish Oneplus multicentre randomised trial. Setting Five obstetric units in Sweden between December 2018 and March 2020. Participants Inclusion criteria in the Oneplus trial were women
Background: Patients with advanced ovarian cancer (AOC) undergoing surgery are often subjected to red blood cell (RBC) transfusions. Both anemia and RBC transfusion are associated with increased morbidity. The aim was to evaluate patient recovery after the implementation of patient blood management (PBM) strategies.Methods: This retrospective cohort study included 354 patients with AOC undergoing
Petrochemical production is tightly entangled with fossil fuel extraction and constitutes the primary driver of oil demand growth. Therefore, scholars have increasingly started exploring the linkages between fossil fuels and chemicals, tracing their importance for the political economy of energy transitions. A defining feature in the global petrochemical industry is that the majority of the recent
BackgroundThe primary aim of specialised palliative care (SPC) is to improve the quality of life (QoL) for patients with a high symptom burden from a life-threatening disease. This randomised study aimed to assess the QoL impact of early integration of SPC alongside tumour-specific palliative treatment in patients with gastrointestinal (GI) cancers.MethodsWe randomly assigned ambulatory patients w
Climate warming exacerbates the degradation of the mountain cryosphere, including glacier retreat, permafrost degradation, and snow cover reduction. These changes dramatically alter the local and downstream hydrological regime, posing significant threats to basin-scale water resource management and sustainable development. However, this issue is still not adequately addressed, particularly in moun
The Sjuøyane archipelago is the northernmost land area of Svalbard; thus, it provides a window to study the terrestrial glacial history and dynamics of the Svalbard–Barents Sea Ice Sheet and complement marine geological studies in the region. To reconstruct the glacial history of Sjuøyane, we describe coastal sedimentary sections in Quaternary sediments and constrain their chronology by radiocarbo
To meet climate targets, expanding Populus spp. tree cultivation is proposed as a potential biomass feedstock, especially on agricultural land that does not come into conflict with food production. However, biomass potential assessments typically overlook landowners' perspectives, risking a gap between theoretical potentials and realisation. Here, we test empirical consequences of two hypotheses b
One risk of continuous renal replacement therapy (CRRT) is inadvertent hypothermia (IH), which is defined as a non-therapeutic core temperature decrease below normal. In continuous renal replacement therapy, heat loss will always occur from blood pumped through the dialysis circuit to cooler environment, predisposing for hypothermia. Blood flow and effluent flows are the most important parameters
