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A variational approach, based on a discrete representation of the chain, is used to calculate free energy and conformational properties in polyelectrolytes. The true bond and Coulomb potentials are approximated by a trial isotropic harmonic energy containing force constants between all monomer-pairs as variational parameters. By a judicious choice of representation and the use of incremental matri

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Hypothermia (33°C) dramatically diminishes ischemic but not hypoglycemic brain damage. The beneficial effects of hypothermia in ischemia have been partly attributed to a reduction in the ischemia-induced increase in synaptic levels of glutamate or aspartate. With the microdialysis technique, we studied the effects of hypothermia (33°C) on the brain extracellular levels of glutamate and aspartate d

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We report results from our atmospheric flask sampling network for three European sites: Lutjewad in the Netherlands, Mace Head in Ireland and the North Sea F3 platform. The air samples from these stations are analyzed for their CO2 and O2 concentrations. In this paper we present the CO2 and O2 data series from these sites between 1998 and 2009, as well as the atmospheric potential oxygen (APO). Th

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The regional atmospheric model REMO is used to study the energy and water exchange between surface and atmosphere over the Baltic Sea and its catchment area. As a prerequisite for such studies, the model has to be validated. A major part of such a validation is the comparison of simulation results with observational data. In this study the DX product of the International Cloud Climatology Project

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Background: Peptidyl-prolyl isomerases (PPIases) catalyze cis/trans isomerization of peptidyl-prolyl bonds, which is often rate-limiting for protein folding. SlyD is a two-domain enzyme containing both a PPIase FK506-binding protein (FKBP) domain and an insert-in-flap (IF) chaperone domain. To date, the interactions of these domains with unfolded proteins have remained rather obscure, with structu

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Larvae and pupae of two Neotropical choreutids, Rhobonda gaurisana Walker and Zodia scintillana (walker) (Lepidoptera: Choreutidae), are described. Photographs, drawings, and scanning electron micrographs are provided for both species, and observations on larval behavior and biology are reported. The larval head in both genera is reinterpreted as being semiprognathous. The D2 setae on A9 arise fro

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Background: Criminal offending is strongly transmitted across generations. Aims: To clarify the contribution of rearing environment to crossgenerational transmission of crime. Method: Using Swedish national registries, we identified 1176 fullsibling and 3085 half-sibling sets from high-risk families where at least one sibling was adopted and the other raised by the biological parents. Results: Ris

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Background and aims We aimed to identify clusters of metabolic syndrome (MetS) components, risky for extremely high intima-media thickness. Methods We studied 41,513 volunteers (men and women) from eleven cohorts worldwide, participating in the MARE (Metabolic syndrome and Artery REsearch) Consortium. Results Specific clusters of MetS components - high triglycerides-high blood pressure-abdominal o

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Considering that businesses, whether they operate on a global or a domestic market, are affected by globalization, cross-cultural management is without doubt an urgent topic in current management and education. However, despite this urgency and the commendable intention behind the endeavour to enhance people’s cultural knowledge, current models on national cultures are problematic since they rely

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Popular Abstract in Swedish I avhandlingen studeras plasminogenaktiverings-systemets (PA-systemets) komponenter i livmoderslemhinnan. PA-systemet reglerar omvandlingen av plasminogen till plasmin. Plasminogen är ett inaktivt enzym som finns överallt i kroppsvätskor samt i kroppens olika organ. Aktiveringen katalyseras av aktivatorer, antingen urokinase plasminogen activator (uPA) eller tissue plasThe release of urokinase plasminogen activator (uPA) from endometrial stromal cells decreased after progesterone stimulation, due to upregulation of PA inhibitor 1 (PAI-1) and uPA receptor (uPAR). Subsequently, the uPA:PAI-1 complex was internalized and degraded via uPAR. Predecidual cells in the late secretory phase expressed PAI-1 and uPAR, supporting a specific role for predecidual cells in the

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Popular Abstract in Swedish Röntgen och isotopundersökning vid knäledsartros: en jämförelse med magnetkamera-undersökning Denna avhandling utgör en del av ett större forskningsprojekt om tidig artros (s.k. broskförslitning) i knäleden. Studien omfattar nästan 200 personer med knäsmärta, som när projektet startade 1990 var mellan 35 och 54 år. Vår avsikt är att under minst 10 års tid regelbundet uThe aim was to compare radiography of the tibiofemoral joint (TFJ) and the patellofemoral joint (PFJ), as well as bone scinigraphy with MR imaging in middle-aged individuals with chronic knee pain in the format of a prospective study of knee osteoarthritis. Individuals aged 35-54 years with chronic knee pain were identified. The prevalence of chronic knee pain was 15% (279/2000). Within this grou

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Popular Abstract in Swedish Utvecklingen av offentlig sektor har de senaste årtiondena till stor del påverkats av New Public Management. Som en konsekvens av detta har en ”marknadisering” av offentliga verksamheter och organisationer skett. Denna ”marknadisering” har resulterat i att det finns organisationer i offentlig sektor som varken passar in på beskrivningen av offentliga organisationer elleDuring the last decades the influence of New Public Management and the “marketisation” of public services, have given us organisations in the public sector that fit neither the mould of what constitutes public sector organisations nor that of private companies. Instead, we now have so-called hybrid organisations. These have become an attractive alternative to the more “bureaucratic” public agencie