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Survival of rats with N29 brain tumours after irradiation with 5 or 15 Gy and immunization with IFN-gamma secreting tumour cells

Intra cerebral tumours were inoculated into the brain of Fischer-344 syngeneic rats. After one week they were treated with either 5 or 15 Gy of Co-60-gamma radiation. The first immunization was given 1 hour before the radiation treatment and then two more times with 14-day intervals. Immunization was performed with 3 x 10(6) radiation sterilized IFN-gamma secreting tumour cells (N29) injected intr

The environment and the origins of islet autoimmunity and Type 1 diabetes.

Type 1 diabetes involves the specific destruction of the pancreatic islet β-cells, eventually resulting in a complete dependency of exogenous insulin. The clinical onset of diabetes is preceded by the appearance of autoantibodies against β-cell antigens. The human leukocyte antigen (HLA) region is the single most important genetic determinant of Type 1 diabetes susceptibility, yet variability in t

Excited state and charge photogeneration dynamics in conjugated polymers

Conjugated polymers are becoming interesting materials for a range of optoelectronic applications. However, their often complex electronic and structural properties prevent establishment of straightforward property-function relationships. In this paper, we summarize recent results on the photophysics and excited state dynamics of conjugated polymers, in order to paint a picture of exciton formatio

The loss of a spirit: Metaphor and practice in Aymara decolonization

This paper explores the bearing had by Aymara notions of spirit loss on contemporary indigenous discourses of colonialism and decolonization and discusses the dynamics of cross-fertilization between “traditional” curing practices and cosmology on the one hand and indigenous ethnopolitical activism and discourse on the other.

Altered Consciousness in Religion

Mysticism can be regarded as an integral element of religion. It includes both a way of life and a direct consciousness of the presence of God. Broadly defined as such, one can encounter mystical dimensions within all religions of the world. In order to alter consciousness, mystics in different traditions use a variety of techniques – different types of meditation, visualisation, repetitive prayer

On the Spiral Structure of NGC 5248: An Analytic Approach

An improved nonlinear asymptotic theory of spiral density waves is developed. It extends the theory developed by Yuan & Kuo to a global theory, not just one limited to the vicinity of the resonance. It can then be applied to the recent high-resolution observations of CO and HST NICMOS of nearby spiral galaxies. As an example, we apply the theory to the nearby grand-design spiral galaxy NGC 524

An Exact Ewald Summation Method in Theory and Practice

We present the widespread Ewald summation method in a new light by utilizing a truncated Gaussian screening charge distribution. This choice entails an exact formalism, also as particle mesh Ewald, which in practice is not always the case when using a Gaussian screening function. The presented approach reduces the number of dependent parameters compared to a Gaussian and, for an infinite reciproca

B-1 Cells Carry the Memory of Neonatal Immune Imprinting

Group A Streptococcus is a common pathogen that elicits a protective humoral response against the cell wall component GlcNAc. In this issue of Immunity, New et al. demonstrate the ability of long-lived B-1 cells to be programmed by microbial colonization and early life immunization to uniquely incorporate GlcNAc reactivity in mice, establishing their critical role in mediating neonatal immune impr

Vaccination against atherosclerosis? Induction of atheroprotective immunity

Atherosclerosis involves the formation of inflammatory arterial lesions and is one of the most common causes of death globally. It has been evident for more than 20 years that adaptive immunity regulates the magnitude of the atherogenic proinflammatory response. T cells may also influence the stability of the atherosclerotic lesion and thus the propensity for thrombus formation and the clinical ou

Evaluation of a colorimetric assay based on 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) for rapid detection of rifampicin resistance in Mycobacterium tuberculosis

OBJECTIVES: To standardise the colorimetric assay based on 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) for the rapid detection of rifampicin-resistant Mycobacterium tuberculosis in clinical practice and to evaluate the assay on a collection of 92 clinical isolates. DESIGN: The Bactec method was used as the reference method. Rifampicin was used for the susceptibility testing

Increased neutrophil membrane expression and plasma level of proteinase 3 in systemic vasculitis are not a consequence of the - 564 A/G promotor polymorphism.

Several findings link proteinase 3 (PR3) to small vessel vasculitis. Besides being a major target of anti-neutrophil cytoplasm antibodies (ANCA), previous findings have shown increased circulating levels of PR3 in vasculitis patients, increased levels of neutrophil membrane-PR3 (mPR3) expression and a skewed distribution of the − 564 A/G polymorphism in the promotor region of the PR3 gene. In this

Fluorescence detection and assessment on tryptophan content of naked oat varieties in China

The experiment aims to assess the tryptophan content of main cultivars of naked oat in China, and analyze the correlation between contents of tryptophan and protein. Oat flour was hydrolysed with papain, the fluorescence intensity of hydrolysate was detected at excitation wavelength of 288 nm and emission wavelength of 352 nm, and finally the tryptophan content was quantitated according to standar