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Microbial immunoglobulin A (IgA) proteases cleave human secretory IgA, promoting the mucosal adhesion of pathogens. To investigate if the enteric protozoan Blastocystis degrades human secretory IgA, cell lysate and conditioned medium from two species were exposed to immunoglobulin A. Secretory IgA was cleaved by both cell lysate and conditioned medium with mainly cysteine proteinase activity in B.

On Sufi gatherings in London and the impact of a visiting shaykh.

A soy protein film coating was developed and evaluated to reduce fat transfer in deep-fried foods during frying. Soy protein isolate solutions (10% SPI) with 0.05% gellan gum as plasticizer cooled after being held at 80 degrees C for 20 min provided suitable films. There was a significant fat reduction (55.12(+/-6.03)%db) between fried uncoated and coated discs of doughnut mix. The same films were

Background Direct cell reprogramming is characterized by the use of defined factors to rewire the transcriptional and epigenetic network of one cell-type into one of a different lineage. We have recently identified the transcription factors PU.1, IRF8, and BAFT3 (PIB) as sufficient to induce a type 1 conventional dendritic cell (cDC1) fate in both somatic and cancer cells.1,2 cDC1 is a rare dendri

What role has music played in global colonial projects? And how has musical colonisation been implemented on a large scale? To address these questions, I analyse the work of the evangelical missionary administrators Christian Ignatius Latrobe (1756–1836) and Hans-Peter Hallbeck (1784–1840). Latrobe was a London-based music historian, composer and editor who oversaw the missionary work of the Morav

Social interaction research is lacking an experimental paradigm enabling researchers to make causal inferences in free social interactions. For instance, the expressive signals that causally modulate the emergence of romantic attraction during interactions remain unknown. To disentangle causality in the wealth of covarying factors that govern social interactions, we developed an open-source video-

Atrial fibrillation (AF) is a complex condition caused by various underlying pathophysiological disorders and is the most common heart arrhythmia worldwide, affecting 2 % of the European population. This prevalence increases with age, imposing significant financial, economic, and human burdens. In Europe, stroke is the second leading cause of death and the primary cause of disability, with numbers

Japan’s decision to end it contribution to the U.N.’s top gender equality body could hardly come at a worse time, both diplomatically and symbolically.

The effort to electrify society has in recent years resulted in major changes in the transportation sector. Charging time remains a challenge in several applications such as transportation and heavy machinery. A proposed solution that shortens the energy replenishment time and adds flexibility in loading the grid is to battery-swapping: exchanging the depleted battery for a fully charged one. In s

BACKGROUND: Existing conceptions of teaching quality assume that classroom interactions serve as the foundation for effective teaching. The resulting data necessitates analytical approaches capable of extracting the semantics of these interactions.AIM: This study investigates whether and to what extent lesson semantics provide insights into teaching quality (i.e., cognitive engagement, encourageme

This paper provides a historical overview of the United Nations Framework Convention on Climate Change Conference of the Parties meetings and reviews the major outcomes of the meetings up to the most recent, which took place in Dubai. We describe how climate negotiations, agreements and policies have evolved, summarise the main points reached, and highlight the key concerns of low-income countries

We investigated the role of cultural experience in the search advantage for happy faces. European British participants living in the UK, Asian Japanese participants living in Japan, and Asian Japanese participants living in the UK, were required to search for a happy or an angry face target against a background of neutral facial expressions, using Asian Japanese and European American faces. Result

PURPOSE: Radiation to the bone and exposure to alkylating agents increases the risk of bone cancer among survivors of childhood cancer, but there is uncertainty regarding the risks of bone tissue radiation doses below 10 Gy and the dose-response relationship for specific types of chemotherapy.METHODS: Twelve European countries contributed 228 cases and 228 matched controls to a nested case-control