Sökresultat

Site I of antigenic domain 2 (AD-2) on human cytomegalovirus glycoprotein B (gB) is poorly immunogenic in both man and mouse and knowledge about antibody repertoires reactive with this epitope is thus limited. Here we have characterized a phage display-derived repertoire of antibody fragments specific for this epitope in terms of antigen recognition, fine-specificity, and virus-neutralizing capaci

The nuclear receptor peroxisome proliferator-activated receptor delta [PPARdelta/beta (NR1C2)] has been implicated in colorectal carcinogenesis by various molecular genetic observations. These observations have recently been supported by studies of activation of PPARdelta by pharmacological agents. Here we present the first report of the stimulation of breast and prostate cancer cell growth using

Bacillus subtilis strain 168 encodes two flavocytochromes P450, Cyp102A2 and Cyp102A3. The cyp102A3 gene is preceded by, and organized in an operon with, a gene for a transcriptional regulator, encoded by fatR. The paralogous gene, cyp102A2, is most likely transcribed as a mono-cistronic message. We show that fatR encodes a protein that binds to an operator sequence that is present upstream of its

Glycobiology is the world of sugars: how they are made, what they look like, and what they do. Despite the importance of glycan structures in life, knowledge has been hampered due to their inherent complexity. Lectins are nature's way to decipher the intricate code held by glycans, which makes them important players in both normal and pathological physiology. A key to the understanding of lectins

The crystal structures of zinc(II) and cadmium(II) sulphides are not affected by the stoichiometry of metal and sulphide ions at the precipitation of the two compounds. The composition and structure of the ultimate surface layers, and thereby the chemical properties of the particles, are on the other hand sensitive to the stoichiometry at the preparation. Chemisorbed ethylxanthate complexes are fo

Once activated, some T cells home to distinct sites in the body, such as the intestine and inflamed skin. Research in mice shows that dendritic cells in the gut produce a derivative of vitamin A, retinoic acid, that gives T cells directions.

This article is a window into conceptual space through antonyms, negated antonyms and antonyms modified by degree modifiers. It investigates native speakers’ understanding of negation in combination with BOUNDED antonymic adjectival meanings and also in relation to their interpretations of the approximating degree modifier, ‘almost’ in Swedish. The results of the investigation are compared with a

Pathogenic microbes have evolved sophisticated molecular strategies to subvert host defenses. Here we show that virulent bacteria interfere directly with Toll-like receptor (TLR) function by secreting inhibitory homologs of the Toll/interleukin-1 receptor (TIR) domain. Genes encoding TIR domain containing–proteins (Tcps) were identified in Escherichia coli CFT073 (TcpC) and Brucella melitensis (Tc

In the frame of an encyclopedic article, a surview of the famous baroque Jesuit author Jacob Balde's life and his diverse oeuvre of Latin poetry is given.

The article is based on a pilot study of the stories of Swedish patients having had a kidney transplant abroad. Our focus is on how people who have been transplanted abroad talk about and handles the dilemma that may arise due to the transplantation trips.

I identify what I see as three aspects of contemorary cosmopolitan philosophy: A certain moral consciousness, a commitment to moral universalism, and an institutional implication of the first two. The third of these is often regarded as a fall-out or consequence of the other two. I argue instead that the institutional aspect should be regarded as primary and that a distinctive feature of cosmopoli

Examples from the affective domain have been plentifully employed for illustrating and sustaining the claims of the conceptual metaphor theory (Lakoff 1980, 1992, Kövecses 1986, 1990, 2000, King 1989, Yu 1995, Matsuki, 1995, Soriano-Salinas 2003, etc.). According to this position, affective concepts (as many other abstract concepts) are metaphorically structured, i.e. conceptualized in terms of mo

As an introduction to the volume, this chapter discusses some of the methodological problems involved in assessing the questions of the historical Jesus’ engagement with the Scriptures of Israel. It is claimed that any method for studying the historical Jesus must take into account the two major tasks of Jesus research, viz. ‘authentication’ and ‘interpretation’. The article then discusses how ext

It is widely recognised that knowledge and highly-skilled individuals as “carriers” of knowledge (i.e. knowledge spillover agents) play a key role in impelling the development and growth of cities and regions. In this chapter we discuss the relation between the mobility of talent and knowledge flows. In this context, several issues are examined, including the role of highly-skilled labour for regi