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Correction for Residual Effects of B1+ Inhomogeniety on MT Saturation in FLASH-Based Multi-Parameter Mapping of the Brain

Maps of the MT-saturation as derived in FLASH-based multi-parameter mapping (MPM) are largely corrected for effects of flip angle inhomogeneity. Here, we present a heuristic model for residual effects of B1+ that is rooted in the dynamics of macromolecule saturation. Model parameters were validated for brain tissues by variation of the MT-pulse flip angle in an established MPM protocol. White and

Strategy for surveying the proteome using affinity proteomics and mass spectrometry.

Antibody-based microarrays is a rapidly evolving technology that has gone from the first proof-of-concept studies to more demanding proteome profiling applications, during the last years. Miniaturized microarrays can be printed with large number of antibodies harbouring predetermined specificities, capable of targeting high- as well as low-abundant analytes in complex, nonfractionated proteomes. C

Using cluster analysis to examine dietary patterns: nutrient intakes, gender, and weight status differ across food pattern clusters

OBJECTIVE: This study explored the usefulness of cluster analysis in identifying food choice patterns of three groups of adults in relation to their energy intake. DESIGN: Food frequency data were converted to percentage of total energy from 38 food groups and entered into a cluster analysis procedure. Subjects in the emerging food group patterns were compared in terms of weight status, demographi

Mechanisms underlying neoplasia-associated genomic rearrangements

Neoplastic disorders are characterized by recurrent somatically acquired chromosomal aberrations that alter the structure and/or expression of a large number of genes. Most “cancer genes” discovered to date in human neoplasms have been identified through isolation of genes at the breakpoints of balanced chromosomal translocations. Although functional studies of such cancer-causing genes have demon

Lifetime measurements for excited states of rare-earth atoms using pulse modulation of a cw dye-laser beam

By pulse-modulating a cw dye-laser beam and employing the delayed-coincidence technique, we have determined the natural radiative lifetimes of a number of atomic states in rare-earth atoms Eu, Dy, and Yb. In the measurements, which were performed on an atomic beam, exponential decay curves with good statistics were obtained using short measuring times. The general features of the technique are dis

Strong Experiences with Music: Music is Much More than Just Music: A Review Essay

The objects of Alf Gabrielsson's study Strong experiences with music are experiences and insights that exceed by far what is normally included in music experiences. To a great extent, the many (over 500) experiences related in this book are so intense that a reader often cannot avoid comparing them to her or his own experiences with music. The multi-variety of character in music experiences is vie

Strategic climate communication and the crafting of affective atmospheres in vulnerable touristic places

• AimsThis research investigates how different ways of referring to anthropogenic climate change produce different sensory and affective perceptions of nature in an urban destination, and how such perceptions sustain or resist the branding strategy of such place. In doing so, it aims at showing that strategic climate communication works not only rhetorically at the level of representation, but als

Cognitive Therapy for PTSD in Children and Adolescents

Children and adolescents exposed to traumatic events are at high risk of developing posttraumatic stress disorder (PTSD). With the rare exception of very young children, their PTSD presentations at the symptom level are similar to those of trauma-exposed adults, as are their patterns of psychiatric comorbidity, particularly for adolescents. Untreated, at least a significant proportion will carry o

Lexical Semantics

This entry offers a short description of basic research questions, different theories, and topics in lexical semantic research. At the beginning, it states five fundamental questions that all lexical semantics theories need to attend to in descriptions and explanations of their observations and findings. A brief presentation of past and present theoretical approaches on lexical semantics follows,