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Severe infections continue to constitute a large burden, with high mortality and risk of sequelae. Sepsis is a dysregulated host response to an infection that causes life threatening organ damage. Meningitis is a severe infection of the brain that often leads to sepsis and death or lasting neurological damage. The host response is often responsible for more damage than the pathogen itself. This th
In this paper we introduce the notion of complex isoparametric functions on Riemannian manifolds. These are then employed to devise a general method for constructing proper r-harmonic functions. We then apply this to construct the first known explicit proper r-harmonic functions on the Lie group semidirect products Rm⋉ Rn and Rm⋉ H 2n+1, where H 2n+1 denotes the classical (2 n+ 1) -dimensional Hei
Background: Although used extensively worldwide, the effects of general anaesthesia on the human brain remain largely elusive. Moreover, general anaesthesia may contribute to serious conditions or adverse events such as postoperative cognitive dysfunction and delirium. To understand the basic mechanisms of general anaesthesia, this project aims to study and compare possible de novo neuroplastic ch
The Gaia-ESO Survey (GES) observed many open clusters as part of its programme to spectroscopically characterize the various Milky Way populations. GES spectroscopy and Gaia astrometry from its second data release are used here to assign membership probabilities to targets towards 32 open clusters with ages from 1 to 3800 Myr, based on maximum likelihood modelling of the 3D kinematics of the clust
PURPOSE: Although numerous biology-driven subtypes have been described previously in metastatic castration-resistant prostate cancer (mCRPC), unsupervised molecular subtyping based on gene expression has been less studied, especially using large cohorts. Thus, we sought to identify the intrinsic molecular subtypes of mCRPC and assess molecular and clinical correlates in the largest combined cohort
Despite efforts to stimulate the dissemination of green purchasing practices, their uptake in business and industry has so far proven limited. Reasons for the limited progress remain largely unclear. One factor explored in this thesis, is the role of information in the operationalization and dissemination of green purchasing in organizations and supply chains. The importance of knowledge and infor
This report is the result of study that was performed in January and February 2009. It was presented and reviewed at the Annual Meeting of the Law and Society Association: Law, Power, and Inequality in the 21st Century in May 2009. The study empirically examined, or rather examined the lack of, social norms opposing illegal file sharing. A total of over 1,000 respondents have answered the questio
Using [C-14]methylamine as an analogue of ammonium, the kinetics and the energetics of NH: transport were studied in the ectomycorrhizal fungus, Paxillus involutus (Batsch) Fr. The apparent half-saturation constant (K-m) and the maximum uptake rate (V-max) for the carrier-mediated transport derived from the Eadie-Hofstee transformation were 180 mu M and 380 nmol (mg dry wt)(-1) min(-1,) respective
Neurosphere cultures are widely used to propagate multipotent CNS precursors, but their differentiation into neurons or oligodendrocytes is rather poor. To elucidate fate determination in this system, we examined the expression and function of candidate transcription factors in neurospheres derived from different CNS regions during development and adulthood. We observed prominent down-regulation o
The complexation of Cd(II) and Cd(II)-phthalate at the goethite/water interface were investigated by EXAFS and IR spectroscopy, by batch adsorption experiments and by potentiometric titrations at 298.15 K. The EXAFS spectra showed Cd(IT) to form only inner-sphere corner-sharing complexes with the goethite surface sites in the presence and absence of phthalate. EXAFS spectra also showed the presenc
Harmful algal blooms (HABs) have occurred with increasing frequency in recent years with eutrophication and other anthropogenic alterations of coastal ecosystems. Many of these blooms severely alter or degrade ecosystem function, and are referred to here as ecosystem disruptive algal blooms (EDABs). These blooms are often caused by toxic or unpalatable species that decrease grazing rates by plankt
An experimental system was developed for the rapid measurement of the aspiration/transfer efficiency of aerosol samplers in a wind tunnel. We attempted to measure the aspiration and particle transfer characteristics of two inlets commonly used for sampling airborne Particulate Matter ( PM): the 'Total Suspended Particulate' or TSP inlet, and the louvered 'dichotomous sampler inlet' typically used
We present a microgeographic analysis of 34 allozyme loci and the control region of mitochondrial DNA (mtDNA) in the common vole Microtus arvalis (Pallas, 1779), performed to assess the effects of environmental heterogeneity on the distribution of genetic variation among populations in the Biebrza river valley, NE Poland The common vole occurs there in two types of habitat open grassland and pastu
This special section of an issue of Science and Public Policy grew out of an interest in following the politics of the European Spallation Source (ESS) Facility at Lund, Sweden. The ESS spectacle provided a platform from which to review different research infrastructure projects and to place them in the context of science policy as a whole. Large-scale research infrastructure investments are often
