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The thesis is an attempt to analyse the concept of limitation of liability for maritime claims with multiple legal and policy perspectives. In trying to analyse the issues related to limitation of liability, the thesis explores the historical background to the development of the concept of limitation of liability within both civil and common law. A synoptic overview on the development of intern
Precision agriculture requires detailed information regarding the crop status variability within a field. Remote sensing provides an efficient way to obtain such information through observing biophysical parameters, such as canopy nitrogen content, leaf coverage, and plant biomass. However, individual remote sensing sensors often fail to provide information which meets the spatial and temporal res
The advent of AlphaFold and consumer large language models have elicited unprecedented development of artificial intelligence (AI). AI has had substantial impact in every area of research, including in molecular biology. This is principally in thanks to contributions to the Protein Data Bank and various genome sequence databases, providing an astronomical amount of data for model training. These d
Alzheimer’s disease (AD) is the most common neurodegenerative disorder, affecting millions worldwide. The clinical presentation of AD is heterogenous and often complicated by the presence of multiple co-pathologies, which can overlap with features of other neurodegenerative disorders, underscoring the need for tools to aid accurate and timely diagnosis. Biomarkers for AD span multiple modalities a
Background and purpose: Neuroblastoma is the most common extracranial solid tumour in children. Radiotherapy is commonly part of the multimodal treatment for high-risk patients. The aim of this study is to analyse doses to organs at risk (OAR) in comparative proton and photon treatment plans for children treated for neuroblastoma and report side effects. Patient/material and methods: All children
We present a new way of performing hypothesis tests on scattering data, by means of a perturbatively calculable classifier. This classifier exploits the “history tree” of how the measured data point might have evolved out of any simpler (reconstructed) points along classical paths, while explicitly keeping quantum–mechanical interference effects by copiously employing complete leading-order matrix
This article examines the potential of digital welfare policies and practices to enhance the wellbeing of children in China, and the congruencies and contradictions of such policies with sustainable welfare. Can child welfare be supported digitally in ways that are not environmentally destructive? The rapidly diffusing concepts of digital welfare and sustainable welfare are presented, emphasising
Background: Coronary artery disease (CAD) is a leading cause of death worldwide and increasing cost for society. Genome wide association studies (GWAS) have identified common variants associated with CAD. Combining single nucleotide polymorphisms (SNPs) into a genetic risk score (GRS) can estimate an individual's genetic burden. Objectives: To investigate whether GRS for CAD can predict hospitaliz
The need for energy in water provision and use is obvious, however the drivers are often complex, difficult to assess, and often inconsistently presented. Here we build a clearer definition and conceptual framework of “water-related energy”. We apply this framework to harmonise data and results across disparate studies so that regional estimates of water-related energy can be compared in a consist
Complete resection is the treatment of choice for most pediatric brain tumors, but early postoperative MRI for detection of residual tumor may be misleading because of MRI signal changes caused by the operation. PET imaging with amino acid tracers in adults increases the diagnostic accuracy for brain tumors, but the literature in pediatric neurooncology is limited. A hybrid PET/MRI system is highl
Background. The diagnostic work-up and treatment of patients with neuroendocrine neoplasms (NENs) has undergone major recent advances and new methods are currently introduced into the clinic. An update of the WHO classification has resulted in a new nomenclature dividing NENs into neuroendocrine tumours (NETs) including G1 (Ki67 index <= 2%) and G2 (Ki67 index 3-20%) tumours and neuroendocrine car
A search for heavy right-handed Majorana or Dirac neutrinos N R and heavy right-handed gauge bosons W R is performed in events with a pair of energetic electrons or muons, with the same or opposite electric charge, and two energetic jets. The events are selected from pp collision data with an integrated luminosity of 36.1 fb −1 collected by the ATLAS detector at s=13 TeV. No significant deviations
Nuclear and electronic dynamics in atoms and molecules are the foundation of many physical processes and chemical reactions. Often, these dynamics take place on timescales so much shorter than those commonly encountered that they are called ultrafast. In order to study ultrafast phenomena, time-resolved techniques such as pump-probe experiments, involving ultrafast light pulses, are necessa
The quantum mechanical motion of electrons and nuclei in systems spatially confined to the molecular dimensions occurs on the sub-femtosecond to the femtosecond timescales respectively. Consequently, the study of ultrafast electronic and, in specific cases, nuclear dynamics requires the availability of light pulses with attosecond (asec) duration and of sufficient intensity to induce two-photon pr
Our society is moving towards renewable resources, where biomass, rich incarbohydrates, is producing chemicals and fuel. However, there are severallimitations when it comes to valorisation of the carbohydrates from renewablebiomass. One major hurdle is the over-functional nature of carbohydrates, making them difficult to process by conventional chemistry. Carbohydrate activeenzymes can help overco
Antibody microarrays have emerged as an important tool within proteomics, enabling multiplexed protein expression profiling in both health and disease. The design and performance of antibody microarrays and how they are processed are dependent on several factors, of which the interplay between the antibodies and the solid surfaces plays a central role. In this study, we have taken on the first com
The flat periwinkles, Littorina fabalis and L. obtusata, comprise two sister gastropod species that have an enormous potential to elucidate the mechanisms involved in ecological speciation in the marine realm. However, the molecular resources currently available for these species are still scarce. In order to circumvent this limitation, we used RNA-seq data to characterize the transcriptome of fou
